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Stereotactic
Radiosurgery and Interstitial Brachytherapy for Glial Neoplasms
M.W. McDermott, M.S. Berger, Sandeep Kunwar, Andrew T.
Parsa, P.K. Sneed, David A. Larson
Department of Neurosurgery, University
of California, San Francisco, CA, USA [MWM, MSB, DAL]. Department of Radiation Oncology, University of California, San Francisco, CA,
USA [MWM, SK, ATP, PKS, DAL].
The
application of focal radiation therapies in the management of malignant gliomas
has gone through a number of stages.
Earlier efforts to improve local control of malignant gliomas involved the use
of brachytherapy.
Despite some early encouraging results, Phase 3 studies did not prove a
significant survival benefit for the addition of brachytherapy for newly
diagnosed glioblastoma.
Most recently radiosurgery has been employed using the same rationale in that
improved local control may improve survival.
Results of the RTOG Phase 3 study are pending final publication, but early
abstracted reports are negative.
While radiosurgery and brachytherapy continue to be used as a form of therapy
for selected patients with recurrent gliomas, new information from metabolic
imaging studies suggests our problem with these techniques in part may be
related to targeting.
This paper reviews the recent literature and results of the use of brachytherapy
and radiosurgery in the management of newly diagnosed and recurrent malignant
gliomas.
Keywords: brachytheraphy,
malignant glioma, radiosurgery
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source: http://ipsapp007.kluweronline.com/IPS/content/ext/x/J/5042/I/124/A/6/abstract.htm
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