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Radiation-induced tumor after stereotactic radiosurgery and
whole brain radiotherapy: case report and literature review
McIver JI, Pollock BE
Department of Neurological Surgery, Mayo Clinic and Foundation,
Rochester, MN 55905, USA.
Radiation-induced neoplasms are extremely rare after stereotactic
radiosurgery.
To date, only 3 cases meet Cahan's criteria in the world literature.
We present a fourth case of a radiation-induced neoplasm arising after
radiosurgery.
The patient is a 43-year-old woman who presented with a right cerebellar
anaplastic astrocytoma 64 months after radiosurgery for metastatic
melanoma.
Initially, 3 brain metastases involving the inferior right temporal (2 tumors)
and right frontal regions were treated.
Following radiosurgery, the patient underwent whole brain radiotherapy (37.5
Gy).
Twenty-two months later, a second radiosurgical procedure was performed for a
recurrent right temporal lobe metastasis.
The area of cerebellum where the glioma developed received a maximum dose of 7.7
and 1.5 Gy during the 2 procedures, respectively.
Support that radiosurgery contributed to the development of this glioma are the
tumor's location and the rarity of adult cerebellar astrocytomas.
The risk of radiation-induced tumors after radiosurgery is unknown.
To better define the incidence of radiation-induced neoplasms after
radiosurgery, all potential cases should be presented and discussed in an open,
candid fashion.
PMID: 15015661 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15015661
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