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L-2-hydroxyglutaric aciduria and brain
malignant tumors: a predisposing condition?
Moroni I, Bugiani M, D'Incerti L, Maccagnano C, Rimoldi M, Bissola L, Pollo
B, Finocchiaro G, Uziel G.
Department of Child Neurology, National Neurological Institute C.
Besta, Milan, Italy.
L-2-hydroxyglutaric aciduria is a rare metabolic encephalopathy displaying a
subcortical leukoencephalopathy on MRI.
Diagnosis rests on detection of an abnormal accumulation of L-2-hydroxyglutaric
acid in body fluids.
The authors report on four patients who developed a malignant brain tumor during
the course of the disease.
This association points to a possible role of L-2-hydroxyglutaric aciduria in
predisposing to brain tumorigenesis.
PMID: 15159502 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15159502
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