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Matrix metalloproteinase-2 and matrix
metalloproteinase-9 expressions correlate with the recurrence of intracranial
meningiomas
Okada M, Miyake K, Matsumoto Y, Kawai N, Kunishio K, Nagao S
Department of Neurological Surgery, Kagawa Medical University,
Kita County, Kagawa, Japan. neuron@kms.ac.jp
Background. We studied whether or not the expressions of MMP-2 and MMP-9
were correlated with the proliferative potential or recurrence of intracranial
meningiomas.
Methods. The expressions of MMP-2 and MMP-9 of 56 meningioma tissues
were examined and scored by immunohistochemistry (IHC).
Expressions of the mRNA of each MMP were also examined by reverse transcriptase
polymerase chain reaction (RT-PCR) assay in 15 cases.
The relationships between IHC score and each of age, sex, tumor location,
histology, MIB-1 labeling index (LI), and recurrence or regrowth rate were
studied.
Results. Nine of 56 cases showed recurrence or regrowth.
IHC revealed that MMP-2 was highly expressed in 13 of 56 cases, whereas MMP-9
was highly expressed in 22 of 56 cases.
Among the 15 cases analyzed by RT-PCR assay, MMP-2 and MMP-9 were expressed in 9
and 13 cases, respectively.
Based on the Kaplan-Meier curve, the high expressions of MMPs were related to
recurrence/regrowth (MMP-2: p < 0.001; MMP-9: p < 0.05).
No significant relationship was observed between the expressions of MMPs and
either age, sex, tumor location, or MIB-1 LI.
Conclusions. Our study indicated that MMP-2 and MMP-9 expressions are
prognostic factors predicting the recurrence of meningioma, independent of
proliferative potential.
PMID: 15015767 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15015767
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