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Getting at the root and stem of brain tumors
Oliver TG, Wechsler-Reya RJ
Department of Pharmacology and Cancer Biology, Duke University
Medical Center, Durham, NC 27710, USA.
Brain tumors are among the most aggressive and intractable types of
cancer.
Recent studies indicate that brain tumor cells resemble neural stem cells in
terms of phenotype, signaling, and behavior in vitro.
In light of these similarities, it has been suggested that brain tumors arise
from stem cells, that they co-opt stem cell strategies for self-renewal, and
even that they contain "cancer stem cells" that are critical for tumor
maintenance.
We will examine these possibilities and discuss their implications for the
understanding and treatment of brain tumors.
Copyright 2004 Cell Press
PMID: 15207233 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15207233
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