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The
relationship between peritumoral brain edema and the expression of
vascular endothelial growth factor and its receptors in intracranial
meningiomas
Shinji Otsuka, Takashi Tamiya*,
Yasuhiro Ono, Hiroyuki Michiue, Kazuhiko Kurozumi, Shigeru Daido,
Hirokazu Kambara, Isao Date, Takashi Ohmoto
Department of Neurological
Surgery, Okayama University Graduate School of Medicine and Dentistry,
Ikenobe, Mikicho, Kida-gun, Kagawa, Japan. *Department of Neurological
Surgery, Okayama University Graduate School of Medicine and Dentistry,
Ikenobe, Mikicho, Kida-gun, Kagawa, Japan; Department of Neurological
Surgery, Kagawa University School of Medicine, 1750-I Ikenobe,
Ikenobe, Mikicho, Kida-gun, Kagawa, 761-0793, Japan (tamiya@kms.ac.jp).
We examined the radiological
and histological features of, and the influences of the expression of
VEGF and its two major receptors, Flt-1 and Flk-1, on the development
of peritumoral brain edema (PTBE) in patients with intracranial
meningiomas.
The expressions of VEGF and
VEGF receptors in the immunohistochemical study were analyzed in
relation to several factors, including tumor size, location,
vascularity, and blood supply, as seen on digital subtraction
angiographic studies.
The edema volume (P = 0.0003) and edema index (P < 0.0001) had a
significantly positive relation to VEGF expression.
The positivity of Flt-1 and
Flk-1 was mainly observed in tumor vessels; 44 cases (37.2%) were
positive for the Flt-1 antibody and 37 cases (31.4%) for the Flk-1
antibody.
The mean value of the edema
index of the positive-Flt-1 group (5.220 ± 11.586)
was significantly higher than that of the negative-Flt-1 group (1.782 ± 2.559) (P < 0.0001).
The mean value of the edema index of the positive-Flk-1
group (3.925 ± 5.870) was slightly higher
than that of the negative-Flk-1 group (2.671 ± 8.136) (P <
0.0001).
Our data
suggest that the expressions of VEGF and VEGF receptors positively
relate to each other and to the formation of PTBE in patients with
meningiomas.
Keywords: brain edema, meningioma, VEGF,
VEGF receptor
Copyright © 2004 Kluwer Academic Publishers.
All rights reserved
Source: http://ipsapp009.kluweronline.com/IPS/content/ext/x/J/5042/I/126/A/5/abstract.htm
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