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Patients with primary brain tumors as organ
donors: case report and review of the literature
Punnett AS, McCarthy LJ, Dirks PB, Hawkins C, Bouffet E
Pediatric Brain Tumor Program, Department of Pediatrics, Hospital
for Sick Children, Toronto, Ontario, Canada.
Malignancy is considered a contra-indication to organ donation, with a few
possible exceptions.
We present the case of a child with fatal intracranial hemorrhage from a primary
brain tumor (PBT) whose organs were denied for transplant after recovery.
We review the literature of organ donors with PBTs in the context of the current
organ shortage and discuss the implications for the practicing oncologist.
Transmission of donor brain tumor to organ recipients has been documented but
the incidence appears to be very low.
Risk factors for tumor transmission include underlying donor tumor histology,
history of craniotomy and/or shunt placement, use of systemic chemotherapy and
radiation therapy, and duration of disease prior to donation.
Ongoing data collection by national registries will provide more information on
the potential risk to organ recipients.
It may be appropriate to expand the donor pool to include donors with PBTs in
certain situations.
The transplantation team ultimately decides upon the use of organs from specific
donors.
Many families will appreciate the opportunity to donate specific tissues even if
solid organ transplantation is prohibited.
Copyright 2004 Wiley-Liss, Inc.
PMID: 15170894 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15170894
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