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Prognostic Value of Mdm2, p53 and p16
in Patients with Astrocytomas
Stella M. Ranuncolo, Mirta
Varela, Ana Morandi, José
Lastiri, Silvia Christiansen, Elisa Bal de Kier Joffé,
María
G. Pallotta, Lydia Puricelli
Research
Area of the Institute of Oncology 'Angel H. Roffo', Buenos Aires, Argentina (S.M.R.,
E.B.K.J., L.P.); Hospital
Italiano, Buenos Aires, Argentina (M.V., A.M., J.L., S.C., M.G.P.).
Surgical cure of gliomas infiltrating into the brain is practically
impossible and their clinical course is primarily determined by the biological
behavior of the tumor cell.
The purpose of this study was to analyze retrospectively prognostic input of
p53, Mouse double minute-2 (Mdm2) and p16 in 103 uniformly treated patients with
astrocytic tumors.
The expression of these molecules was measured by immunohistochemical
procedure.
Prognostic evaluation was performed with the multivariate proportional hazards
model.
The follow-up period lasted 19 (5–122) months
for the survivors.
We observed that 66% of gliomas showed mutated p53, while only 17% overexpressed
Mdm2, the p53-regulatory molecule.
Besides, almost 50% of gliomas lost p16 immunopositivity.
Only p53 labeling showed a positive correlation with the grade of malignancy,
according with the WHO classification.
The association between mutated p53 and histological grade remained when
prognostic variables were considered in a multivariate analysis.
No association between p53 status and overall survival was found.
On the other hand, Mdm2 overexpression and, unexpectedly, p16 immunopositivity
were associated with a shorter survival in an univariate analysis.
However, Cox-regression analysis showed that only Mdm2 in female patients was an
independent prognostic factor, associated with shorter survival.
In conclusion, our results suggest that Mdm2 could be a relevant marker
in determining the evolution of glioma patients and could provide a more
objective way to classify astrocytomas.
Keywords:
astrocytoma, glioma, invasion, Mdm2, p16, p53, tumor marker
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source: http://journals.kluweronline.com/article.asp?PIPS=5268440
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