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Carcinomatous
Meningitis in Cancer of the Uterine Cervix
M.E.M. Rentinck, H.M. Schrijver, E. Kneppers, J.C.M.
Zijlmans, C.J. van Groeningen
Department
of Medical Oncology [M.E.M.R., E.K., C.J.van G.]. Department of Neurology, VU
Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands; Tel.:
+31-20-4440718; Fax: +31-20-4442800; E-mail: HM.Schrijver@vumc.nl
[H.M.S.]. Department of Neurology, VU Medical Center, Amsterdam,
The Netherlands [J.C.M.Z.].
Carcinomatous
meningitis is extremely rare in cervical cancer.
The diagnosis of carcinomatous meningitis is a difficult one when clinical
symptoms are limited and radiographic imaging is normal.
Demonstration of malignant cells in the cerebrospinal fluid remains the gold
standard to establish the diagnosis.
For patients without bulky disease who can be treated with radiotherapy,
standard treatment for carcinomatous meningitis is chemotherapy, which may be
administered intrathecally.
Despite the poor prognosis, treatment may result in effective palliation.
We describe a 54-year-old patient who was diagnosed with carcinomatous
meningitis in the course of metastatic cervical cancer and who responded to
administration of intrathecal methotrexate.
Keywords: carcinomatous
meningitis, cervical cancer, intrathecal chemotherapy, methotrexate
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source: http://ipsapp009.kluweronline.com/IPS/content/ext/x/J/5042/I/123/A/11/abstract.htm
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