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Primary Dural Mucosa-Associated Lymphoid Tissue-Type Lymphoma: Case
Report and Review of the Literature
M. Rottnek,
J. Strauchen,
F. Moore,
S. Morgello
Department of Pathology (Division of Neuropathology)
(M.R., J.S., S.M.), Department of Neurosurgery (F.M.),
The Mount Sinai Medical
Center, New York City, NY, USA
A 47-year-old Hispanic male presented with visual field disturbances,
memory impairment, and a seizure.
CT and MRI were consistent with meningioma.
Both neurologic exam and routine laboratory tests were within normal limits.
The
patient underwent craniotomy and subtotal resection of the tumor.
On H&E,
the lesion was composed of a lymphoid mass with well-defined irregularly shaped
follicles surrounded by a monomorphic population of small lymphocytes.
Marginal
zones stained for B-cell markers, CD20 and CD79a, one T-cell marker, CD43, and
kappa light chains.
While other markers did not stain the majority of tumor
cells, they did identify other lymphoid and plasma cell elements.
A diagnosis of
marginal zone B-cell lymphoma of dura, mucosa-associated lymphoid tissue
(MALT)-type (extranodal) was made.
MALT-type lymphomas are unusual in the
nervous system; this is the first such case reported in a male and serves to
emphasize the wide diversity of presentation of a neoplasm originally described
in the GI tract and thus far described in the CNS only in females.
Keywords: CNS
MALToma, dural lymphoma
Copyright
©
2004 Kluwer Academic Publishers.
All rights reserved
Source: http://journals.kluweronline.com/article.asp?PIPS=5254565
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