From: Subject: Landes Bioscience - Home Date: Sat, 23 Feb 2008 11:56:31 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C87613.2155B3A0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C87613.2155B3A0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.landesbioscience.com/journals/cc/abstract.php?id=795 Landes Bioscience - = Home

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Cancer Stem Cells Persist in Many Cancer Cell Lines

Takao Setoguchi, Tetsuya Taga and Toru = Kondo

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volume 3 | issue 4

april=20 2004
Pages: 414 - 415

We now provide open access to = journal=20 articles published online for one year or more. This article may = be=20 downloaded at the following link:
Download PDF=20 If=20 the document does not open, please right-click on the link = (control-click=20 on a Macintosh) and select the option to save the file to = disk.

Both=20 stem cells and cancer cells are thought to be capable of unlimited = proliferation. Paradoxically, however, some cancers seem to = contain=20 stem-like cells (cancer stem cells). To help resolve this paradox, = we=20 investigated whether established malignant cell lines, which have = been=20 maintained over years in culture, contain a subpopulation of stem = cells.=20 We have shown that four cancer cell lines contain a small side = population=20 (SP), which, in many normal tissues, is enriched for stem cells of = the=20 tissue. We have also shown that SP cells in C6 glioma cell line, = but not=20 non-SP cells, can generate both SP and non-SP cells in culture and = are=20 largely responsible for the in vivo malignancy of this cell line. = We=20 propose that many cancer cell lines contain a minor subpopulation = of stem=20 cells that is enriched in a SP, can be maintained indefinitely in = culture,=20 and is crucial for their malignancy.

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