|
Developmental
neurobiology and the origin of brain tumors
Alan
H. Shih, Eric C. Holland
Department
of Cancer Biology and Genetics [A.H.S.], Department of Surgery (Neurosurgery),
and Neurology [E.C.H.], Memorial Sloan-Kettering Cancer Center, New York, NYUSA.
Our
knowledge of the causes of brain tumors has steadily increased and is leading to
a refined understanding of the signaling pathways that may be essential for
tumor formation.
At the same time, we are gaining insights into the developmental processes that
regulate the formation of the diverse range of cell types in the normal brain.
Interestingly, many of these pathways seem to overlap and suggest common
mechanisms regulating tumor formation and cellular development.
This overlap may also inform us about the nature of the cell of origin for
different types of brain tumors.
By appreciating the inter-relationship between tumor formation and development,
we may be able to design new therapeutics targeting tumors for new modes of
treatment.
Keywords:
developmental
neurobiology, progenitor, signaling
Copyright
©
2004 Kluwer Academic Publishers.
All
rights reserved
Source: http://ipsapp007.kluweronline.com/IPS/content/ext/x/J/5042/I/125/A/2/abstract.htm
|
