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Operable benign meningioma
patients appear to have expected survival that is equivalent to a normal United
States population
S. Soyuer, E. L. Chang, U. Selek, M. H. Maor, F. Demonte
Erciyes University Medical Faculty, Kayseri, Turkey; M. D.
Anderson Cancer Center, Houston, TX; Hacettepe University Medical Faculty,
Ankara, Turkey
Background.
To compare survival from benign meningioma undergoing
resection, with the expected survival from a normal United States population.
Materials and Methods.
Our patient series consisted of 92 patients with
histologically verified benign meningioma (WHO grade I) operated on The
University of Texas M. D. Anderson Cancer Center between March 1953 and January
2001.
The median age was 48 years (range, 17- 93 years), and there was a 2.2
(63/29) preponderance of female patients.
The 5 most common tumor sites in descending order was convexity, falx,
sphenoid wing, cavernous sinus, and clivus.
Forty-eight patients underwent gross total resection, and 44 patients
underwent subtotal resection.
Forty patients underwent adjuvant (n=12) or salvage radiotherapy
(n=28).
The endpoints analyzed were progression-free survival (PFS) and overall
survival (OS).
PFS and OS rates were calculated using the Kaplan-Meier method.
Overall survival curve of the study population is compared with the age,
race, and sex-adjusted expected survival curve for the U.S. Population born in
1970, generated from data obtained from the U.S. Department of Health and Human
Services.
Results.
With a median follow-up of 7.7 years, there were 17 deaths and
44 recurrences in the study population.
The 15-year PFS and OS rates for all patients were 33% and 70%,
respectively.
Superimposition of the the study survival data demonstrates that the
age-adjusted expected survival curve for the U.S. Population born in 1970 lies
within the confidence intervals for overall survival curve of the study
population.
Conclusion.
This finding suggests that operable meningioma patients at a
single institution do not exhibit any greater risk of mortality than that which
would be expected for the normal U.S. population.
Copyright 2004 American Society of Clinical Oncology All rights
reserved worldwide.
Source: http://www.asco.org/ac/1,1003,_12-002636-00_18-0026-00_19-002616,00.asp
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