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ABO blood group is a potent risk
factor for venous thromboembolism in patients with malignant gliomas
Streiff MB, Segal J, Grossman SA, Kickler TS, Weir EG
Department of Medicine, The Johns Hopkins Medical Institutions,
Baltimore, Maryland 21231, USA.
Background.
Venous
thromboembolism (VTE) is a common cause of morbidity and mortality among
patients with malignant gliomas.
To investigate the pathogenesis of VTE and facilitate targeted prophylaxis
strategies, the authors aimed to characterize VTE risk factors in these
patients.
Methods.
The authors
conducted a retrospective chart review of 130 adult patients with glioma who
received their primary therapy at the Johns Hopkins Hospital (Baltimore, MD)
between 1991 and 2001.
Symptomatic VTE was confirmed by objective radiologic testing.
The association between clinical and laboratory characteristics and VTE was
assessed using parametric and nonparametric statistical tests and survival
analysis.
Results.
VTE developed
in 28 patients (21.5%) at a median of 4.8 months after diagnosis (interquartile
range, 2.1-13.2).
Patients with tumors > 5 cm were more likely to develop VTE than patients
with smaller tumors (hazard ratio = 2.2; P = 0.04).
For every year increase in age, the hazard ratios for thrombosis increased by 3%
(P = 0.011).
When stratified by ABO blood group, the hazard ratios for thrombosis were 2.7
and 9.4 for patients with blood groups A (P = 0.045) and AB (P < 0.0001),
respectively, compared with patients with blood group O.
No association was observed between VTE and the other patient characteristics
analyzed.
Conclusions.
Patient
age, tumor size, and particularly ABO blood group are risk factors for VTE among
patients with malignant gliomas.
These findings may facilitate the development of a thrombosis risk score that
will allow physicians to individualize VTE prophylaxis regimens.
Copyright 2004 American Cancer Society.
PMID: 15073862 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15073862
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