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Functional significance of S6K overexpression in meningioma
progression
Surace EI, Lusis E, Haipek CA, Gutmann DH
Department of Neurology, Washington University School of Medicine, St. Louis,
MO.
One common genetic change in anaplastic meningiomas is amplification of
chromosome 17q23 containing the S6 kinase (S6K) gene.
We show, for the first
time to our knowledge, increased S6K mRNA expression in anaplastic meningiomas
compared with benign tumors.
To evaluate S6K as a candidate meningioma
progression gene, we generated IOMM-Lee human meningioma cell lines
overexpressing S6K.
Whereas no effect of S6K overexpression on meningioma cell
growth, motility, or adhesion was observed in vitro, S6K overexpression resulted
in increased tumor size in vivo.
Collectively, these results suggest that S6K is
functionally important for meningioma progression and may represent a target for
future meningioma therapy.
PMID: 15293284 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15293284
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