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Delayed radiation toxicity after focal or
whole brain radiotherapy for low-grade glioma
Swennen MH, Bromberg JE, Witkamp TD, Terhaard CH, Postma TJ, Taphoorn MJ
Department of Neurology, University Medical Centre Utrecht, The
Netherlands.
To evaluate the influence of radiation volume and other risk factors for the
development of delayed radiation toxicity in patients treated for low-grade
glioma, a retrospective analysis of 41 adult patients treated with focal or
whole brain radiotherapy (WBRT) was performed.
For all patients CT and MRI scans were revised to quantify brain atrophy and
white matter lesions.
Medical data were reviewed concerning baseline and tumor characteristics,
treatment, survival, signs and symptoms of clinical encephalopathy and
cardiovascular risk factors.
In patients treated with WBRT an increased risk was found for brain atrophy (RR
3.1), white matter lesions (RR 3.8) and clinical encephalopathy (RR 4.2).
An increased risk of atrophy (RR 2.2) and white matter lesions (RR 2.9) was also
found in patients aged over 40 years.
Furthermore, brain atrophy and white matter lesions were more severe in patients
treated with WBRT and in older patients.
In conclusion, both the incidence and the severity of abnormalities is greater
in patients treated with WBRT and in older patients.
PMID: 15015665 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15015665
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