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Pleomorphic
xanthoastrocytoma: report of two cases and review of the prognostic factors
Tan TC, Ho LC, Yu CP, Cheung FC
Department of Neurosurgery, Queen Elizabeth Hospital, 30
Gascoigne Road, Kowloon, Hong Kong
Pleomorphic xanthoastrocytoma (PXA) is a superficially located, rare glial
tumour first described in 1979.
It affects young patients, who often present with seizures.
The tumour has a relatively favourable prognosis, but 15-20% progress to
malignancy.
We describe two cases of PXA, both with benign features at presentation, one of
which underwent anaplastic transformation.
Surgery remains the mainstay of treatment.
Factors influencing clinical outcome include extent of resection, and
histological features such as mitotic index, necrosis and lymphocytic
infiltration.
The roles of radiotherapy and chemotherapy remain undefined.
We advocate lifelong follow-up and establishment of a central registry in order
to further the understanding of this infrequently encountered tumour.
PMID: 14732386 [PubMed - in process]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14732386&dopt=Abstract
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