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MIB1 proliferation index in meningiomas: does it predict
recurrence? A clinicopathological study
Tyagi A, Chakrabarty A, Franks A
Department of Neurosurgery, General Infirmary at Leeds, UK.
atul.tyagi@leedsth.nhs.uk
The usefulness of proliferation marker MIB1 in predicting recurrences in
cranial meningiomas when other clinical and pathological factors are
considered was assessed.
Data from 65 patients with meningiomas were
analysed and their clinical notes reviewed to define the Simpson grade of
surgical excision, the location of tumour, amongst other clinical factors.
The diagnosis was reviewed; immunohistochemical staining for a proliferation
marker MIB1 was carried out on archival formalin-fixed, paraffin-embedded
tumour and a labelling index for MIB1 (MIB1 L1) calculated.
Analysis was
undertaken of the impact of histology, grade of excision, tumour location
and proliferation index on the risk of recurrence.
The grade of surgical
resection and histology type were the most important factors likely to
predict recurrence.
MIB1 LI was not considered useful in predicting tumour
recurrence.
PMID: 15702834 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15702834
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