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Solitary cerebellar metastasis of malignant
pleural mesothelioma: case report
Winfree CJ, Mack WJ, Sisti MB
Department of Neurological Surgery, The Neurological Institute,
Columbia University, College of Physicians and Surgeons, New York, NY 10032,
USA.
Background. Malignant pleural mesothelioma is an uncommon malignancy that
rarely metastasizes to the central nervous system and even less frequently
occurs as a solitary lesion.
Case Description. We present a 71-year-old white female, nonsmoker,
with no occupational exposure to asbestos.
She presented with a 15-lb. weight loss over several months and persistent right
subscapular pain radiating to her anterior chest.
Imaging studies revealed a pleural mass, and biopsy confirmed fibrous type
malignant pleural mesothelioma.
During a metastatic workup, computed tomography (CT) and magnetic resonance
imaging (MRI) of the head demonstrated a 1 cm subcortical, contrast-enhancing
lesion without surrounding edema in the right posterior cerebellum.
Surgical resection of the solitary cerebellar mass revealed fibrous-type
metastatic malignant mesothelioma.
Postoperatively, the patient received a combined chemotherapy regimen of
Adriamycin and Cisplatin and underwent whole brain radiation therapy.
Conclusions. We report the first resection of a solitary cerebellar
metastasis of malignant pleural mesothelioma.
We also review past cases of intracranial metastasis of this malignancy, its
histologic subtypes, outcome, and recent treatment modalities.
PMID: 14751636 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14751636
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