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Intraventricular chordoid meningioma presenting with
Castleman disease due to overproduction of interleukin-6. Case report
Arima T, Natsume A, Hatano H, Nakahara N, Fujita M, Ishii D, Wakabayashi
T, Doyu M, Nagasaka T, Yoshida J
Department of Neurosurgery, Division of Pathology, Clinical Laboratory,
Center for Genetic and Regenerative Medicine, Nagoya University Graduate
School of Medicine, Nagoya, Aichi, Japan.
A rare case of chordoid meningioma in the lateral ventricle observed in an
adult is reported.
The first clinical manifestation of the disease was a
prolonged fever of unknown origin.
Abnormalities in the patient's blood
chemistry, principally polyclonal hypergammaglobulinemia (immunoglobulin
[Ig]G, IgA, and markedly IgE) and an elevated serum level of C-reactive
protein, were associated with the disease.
The tumor was histologically
confirmed to be a chordoid meningioma, and its surgical removal resulted in
complete resolution of the patient's symptoms.
By combining reverse
transcription-polymerase chain reaction and immunohistochemical analysis, it
may be shown that cytokine production, including that of interleukin (IL)-6,
IL-1beta, and vascular endothelial growth factor, plays a role in the
pathogenesis of chordoid meningioma associated with Castleman syndrome.
PMID: 15871519 [PubMed - in process]
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