|
|
Whole
brain irradiation doses and overall survival in patients with brain metastases
Nada D Bajic, Danijela D Scepanovic
Clinical Centre of Montenegro, Podgorica,
Slovenia
Purpose.
We analyzed influence of three different whole brain radiotherapy (WBRT)
schedules on overall survival (OS) of patients (pts) with brain metastases (BM).
Method.
From 1998 till 2001, 71 pts were treated for metastatic brain disease.
Median age was 54 (min 34 years, max 76 years).
Male : Female ratio was 2 : 1.
Median follow up was 6 months (min 2 months, max 36 months).
Fifteen pts were treated with 30Gy in 10 fractions, 28 pts were treated with 20
Gy in 5 fractions and 28 pts were treated with 40 Gy in 10 fractions split
course technique 1 month.
We also analyzed influence of age, gender, site of primary (Lung 40 pts, Breast
14, Melanoma 1, Unknown primary 12, Kidney 2, Others 2), performance status,
neurosurgical metastasectomy, isolated or disseminated disease status,
reirradiation, following chemotherapy (CT) as independent prognostic factors for
OS.
Results.
Pts treated with whole brain irradiation of 30 Gy had the best OS (median OS was
9 months) while those treated with 20Gy and 40Gy split course had median OS of 6
months (p<0,0035).
Furthermore, CT after the completition of RT significantly improves OS in this
group of pts with median OS of 12 months (p< 0,001).
Performance status (Karnofsky index from 60 to 100%) per se affects the survival
(from 4 to 12 months respectively).
Conclusion.
We find that whole brain irradiation of pts with BM with 30 Gy in 10 fractions
followed by effective CT is the best treatment option in this group of pts
regarding survival.
© Copyright 2002
American
Society of Clinical Oncology
Source:
http://www.asco.org/ac/1,1003,_12-002324-00_18-002002-00_19-002106-00_29-00A-00_42-00ONeill-00_43-00-00_44-00-00_45-00
Author-00_46-00Title-00_47-00Title-00_48-00and-00_49-00and,00.asp?cat=CNS+Tumors&parent=CENTRAL+NERVOUS+SYSTEM+TUMORS
&returnpid=2323
|
