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Journal Article =	=20

Systemic=20 Temozolomide Combined with Loco-regional Mitoxantrone = in=20 Treating Recurrent Glioblastoma

Journal	Journal=20 of Neuro-Oncology
Publisher	Springer = Netherlands
ISSN	0167-594X (Print) 1573-7373 = (Online)
Subject	Medicine
Issue	Volume=20 75, Number 2 / November, 2005
Category	Clinical Study
DOI	10.1007/s11060-005-3030-x
Pages	215-220
Online Date	Friday, November 11,=20 2005

Clinical Study

Systemic = Temozolomide=20 Combined with Loco-regional Mitoxantrone in Treating = Recurrent=20 Glioblastoma

A. Boiardi¹, M. Eoli¹,=20 A. Salmaggi¹, = E. Lamperti¹,=20 A. Botturi¹, = G. Broggi²,=20 L. Bissola³, = G. Finocchiaro³=20 and A. Silvani¹

(1)	Department of=20 Neuro-Oncology, Istituto Nazionale Neurologico = =E2=80=9CCarlo=20 Besta=E2=80=9D, = Italy

(2)	Department of = Neurosurgery,=20 Istituto Nazionale Neurologico =E2=80=9CCarlo = Besta=E2=80=9D,=20 Italy

(3)	Unit of Experimental = Neuro-Oncology and Gene Therapy, Istituto = Nazionale=20 Neurologico =E2=80=9CCarlo Besta=E2=80=9D, = Milano,=20 Italy

Abstract Twenty-two=20 recurrent GBM patients were enrolled for second tumor=20 debulking with local positioning of a Rickam = reservoir, in=20 order to locally deliver chemotherapy with the aim of=20 controlling local tumor recurrence. We designed a = protocol=20 using systemic temozolomide (150 mg/sqm days = 1=E2=80=935 every=20 28) in association with mitoxantrone, delivered = through the=20 reservoir (4 mg/day 1=E2=80=935 every 28) = positioned into the=20 area of tumor exeresis. After re-operation a residual = tumor=20 mass no larger than 2 cm was identified in 18/22=20 patients. The patients were treated with monthly = cycles of=20 chemotherapy until evolution of the tumor, but in no = case for=20 more than 10 cycles. Responses were evaluated by MRI = scans=20 performed every 2 months and images assessed = according to=20 MacDonald=E2=80=99s criteria. Response rate: no = complete responses=20 (CR), 5 partial responses (PR), 13 stable disease (SD) = and 4=20 progressive disease (PD) occurred. The median = progression-free=20 survival (PFS) and survival time (ST) of the whole = group of=20 treated patients was 7 and 11 months, = respectively and=20 more than a quarter of the patients survived over=20 18 months. During the study, the = patients=E2=80=99 compliance was=20 complete and no dropouts occurred. Hematological = toxicity was=20 mild and after repeated local injections only minor=20 neurological side-effects occurred. Despite some bias = in=20 patients=E2=80=99 selection not excluded in this pilot = study, results=20 are interesting: the PFS was as long as the survival = of=20 recurrent GBM reported in the literature.

Keywords loco-regional=20 = chemotherapy - mitoxantrone - recurrent=20 glioblastoma - Rickam=20 reservoir - temozolomide

A. Boiardi
Email:=20 boiardi@istituto-besta.it

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if(items.length > 0) for(var i=3D0; i'); } if (window.frames && window.frames[iframeID]) this.iframe =3D = window.frames[iframeID]; this.iframe.name =3D iframeID; this.iframe.document.open(); this.iframe.document.write(""); this.iframe.document.close(); } this.method =3D method; this.url =3D url; this.async =3D async; }, setRequestHeader: function(name, value) { for(var i=3D0; i=3D 0) tag =3D "textarea"; =09 if(doc.all) { ele =3D doc.createElement("<" + tag + " name=3D\"" + name + "\" />"); }else{ ele =3D doc.createElement(tag); ele.setAttribute("name", name); } ele.setAttribute("value", value); form.appendChild(ele); ele =3D null; }, send: function(data) { if(this.iframe =3D=3D null) { return; } var doc =3D this.iframe.contentDocument || this.iframe.document; var form =3D doc.createElement("form"); =09 doc.body.appendChild(form); =09 form.setAttribute("action", this.url); form.setAttribute("method", this.method); =09 this.setRequestHeader("X-" + AjaxPro.ID + "-Processor", "IFrame"); =09 for(var i=3D0; i=3D " ") { if(c =3D=3D "\\" || c =3D=3D '"') v.push("\\"); v.push(c); } else { switch(c) { case "\n": v.push("\\n"); break; case "\r": v.push("\\r"); break; case "\b": v.push("\\b"); break; case "\f": v.push("\\f"); break; case "\t": v.push("\\t"); break; default: v.push("\\u00"); v.push(c.charCodeAt().toString(16)); } } } return '"' + v.join('') + '"'; case Array: var v =3D []; for(var i=3D0; i0) return "{" + v.join(",") + "}"; return "{}"; =09 } return o.toString(); } }, dispose: function() { if(AjaxPro.queue !=3D null) { AjaxPro.queue.dispose(); } } }, false); addEvent(window, "unload", AjaxPro.dispose); AjaxPro.Request =3D function(url) { this.url =3D url; this.xmlHttp =3D null; }; AjaxPro.Request.prototype =3D { url: null, callback: null, onLoading: AjaxPro.noOperation, onError: AjaxPro.noOperation, onTimeout: AjaxPro.noOperation, onStateChanged: AjaxPro.noOperation, args: null, context: null, isRunning: false, abort: function() { if(this.timeoutTimer !=3D 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args, callback, context) { this.__start =3D new Date().getTime(); if(this.xmlHttp =3D=3D null) this.xmlHttp =3D new XMLHttpRequest(); this.isRunning =3D true; this.method =3D method; this.args =3D args; this.callback =3D callback; this.context =3D context; =09 var async =3D typeof callback =3D=3D "function" && callback !=3D = AjaxPro.noOperation; var json =3D AjaxPro.toJSON(args) + ""; if(AjaxPro.cryptProvider !=3D null) json =3D AjaxPro.cryptProvider.encrypt(json); =09 if(async) { this.xmlHttp.onreadystatechange =3D this.doStateChange.bind(this); this.onLoading(true); } this.xmlHttp.open("POST", this.url, async); this.xmlHttp.setRequestHeader("Content-Type", = "application/x-www-form-urlencoded"); this.xmlHttp.setRequestHeader("X-" + AjaxPro.ID + "-Method", method); =09 if(AjaxPro.token !=3D null && AjaxPro.token.length > 0) this.xmlHttp.setRequestHeader("X-" + AjaxPro.ID + "-Token", = AjaxPro.token); if(!MS.Browser.isIE) this.xmlHttp.setRequestHeader("Connection", "close"); // Mozilla Bug = #246651 this.timeoutTimer =3D setTimeout(this.timeout.bind(this), = AjaxPro.timeoutPeriod); this.xmlHttp.send(json); =09 json =3D null; args =3D null; if(!async) { return this.createResponse({error: null,value: null}); } return true;=09 } }; AjaxPro.RequestQueue =3D function(conc) { this.queue =3D []; this.requests =3D []; this.timer =3D null; =09 if(isNaN(conc)) conc =3D 2; for(var i=3D0; i 0; i++) { if(this.requests[i].isRunning =3D=3D false) { var r =3D this.queue.shift(); this.requests[i].url =3D r[0]; this.requests[i].onLoading =3D r[3].length >2 && r[3][2] !=3D null = && typeof r[3][2] =3D=3D "function" ? r[3][2] : AjaxPro.onLoading; this.requests[i].onError =3D r[3].length >3 && r[3][3] !=3D null && = typeof r[3][3] =3D=3D "function" ? r[3][3] : AjaxPro.onError; this.requests[i].onTimeout =3D r[3].length >4 && r[3][4] !=3D null = && typeof r[3][4] =3D=3D "function" ? r[3][4] : AjaxPro.onTimeout; this.requests[i].onStateChanged =3D r[3].length >5 && r[3][5] !=3D = null && typeof r[3][5] =3D=3D "function" ? r[3][5] : = AjaxPro.onStateChanged; this.requests[i].invoke(r[1], r[2], this.requests[i].callbackHandle, = r); r =3D null; } } if(this.queue.length > 0 && this.timer =3D=3D null) { this.timer =3D setTimeout(this.process.bind(this), 10); } }, add: function(url, method, args, e) { this.queue.push([url, method, args, e]); if(this.timer =3D=3D null) { this.timer =3D setTimeout(this.process.bind(this), 1); } }, abort: function() { this.queue.length =3D 0; if (this.timer !=3D null) { clearTimeout(this.timer); } this.timer =3D null; for(var i=3D0; i 0) element.selectedIndex =3D 0; break; =20 case 'INPUT': switch (getAttributeValue(element, 'type')) { case '', 'text', 'password': element.select(); break; } break; } } } function canAcceptFocus(element) { if (element.style.display =3D=3D 'none' ) return false; =20 return true; } function isDefined(variableName) { return window[variableName] !=3D null; } function toggleVisibility(element, visibleStyle) { if (element =3D=3D null) return; =20 if (visibleStyle =3D=3D null) visibleStyle =3D ''; =20 if (getCurrentStyle(element).display =3D=3D 'none') element.style.display =3D visibleStyle; else element.style.display =3D 'none'; } /* -------------------- End Misc Methods -------------------- */ /* -------------------- String Methods -------------------- */ function trim(text) {=20 return text; while (text.substring(0,1) =3D=3D ' ')=20 { text =3D text.substring(1, text.length); } =20 while (text.substring(text.length-1,text.length) =3D=3D ' ') { text =3D text.substring(0, text.length-1); } } function startsWith(string, value) { if (string =3D=3D null || value =3D=3D null) return false; =20 if (string =3D=3D '' || value =3D=3D '') return false; =20 if (string.length < value.length) return false; =20 return string.substring(string, value.length) =3D=3D value; } /* function endsWith(string, value) { if (string =3D=3D null || value =3D=3D null) return false; =20 if (string.length < value.length) 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function selectedItems_getCount(collection) { var c =3D getCookie(collection); if (c) { return c.split(',').length - 1; } else return 0; } function selectedItems_setSelected(collection, value, select)=20 { =20 if (select)=20 { if (getCookie(collection) =3D=3D null)=20 setCookie(collection, ",'" + value + "'"); else setCookie(collection, getCookie(collection) + ",'" + value + "'"); } else { setCookie(collection, getCookie(collection).replace(",'" + value + = "'", "")); } } function selectedItems_isSelected(collection, value) { var c =3D getCookie(collection); if (c =3D=3D null) return false; else return (getCookie(collection).indexOf(",'" + value + "'") > -1); } function getCookie(key)=20 {=20 if (document.cookie.length > 0)=20 {=20 begin =3D document.cookie.indexOf(key + "=3D");=20 if (begin !=3D -1) {=20 begin +=3D key.length + 1;=20 end =3D document.cookie.indexOf(";", begin); if (end =3D=3D -1)=20 end =3D document.cookie.length; return unescape(document.cookie.substring(begin, end));=20 }=20 } return null;=20 } function setCookie(key, value)=20 {=20 document.cookie =3D key + "=3D" + escape(value) + ";path=3D/"; } function delCookie (key)=20 {=20 if (getCookie(key))=20 { document.cookie =3D key + "=3D" + "; expires=3DThu, 01-Jan-70 = 00:00:01 GMT"; } } function selectedItems_getControls(collection) { var controls =3D new Array(); var boxes =3D document.getElementsByTagName('A'); =20 for (k =3D 0; k < boxes.length; k++) { if (getAttributeValue(boxes[k], 'collection') =3D=3D collection && getAttributeValue(boxes[k], 'isSelectedItemControl') =3D=3D = 'true') { controls =3D controls.concat(boxes[k]); } } return controls; } function selectedItems_setSelectedItemsHyperLinkText(link, count) { var span =3D link.childNodes[1]; if (count =3D=3D 0 || count =3D=3D null) { setInnerText(span, ''); link.style.fontWeight =3D 'normal'; } else =20 { span.innerHTML =3D ' (' + count + ')'; link.style.fontWeight =3D 'bold'; } } function selectedItems_updateSelectedItemsHyperLinkCounts(collection) { var links =3D document.getElementsByTagName('a'); var count =3D selectedItems_getCount(collection); =20 for (var k =3D 0; k < links.length; k++) {=20 if (getAttributeValue(links[k], 'isSelectedItemsLink') =3D=3D 'true' = && getAttributeValue(links[k], 'displayCount') =3D=3D 'true' && getAttributeValue(links[k], 'collection') =3D=3D collection) selectedItems_setSelectedItemsHyperLinkText(links[k], count); } } ------=_NextPart_000_0082_01C6C6EA.10068EF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.springerlink.com/jsMath/plugins/noImageFonts.js /* * noImageFonts.js * =20 * Part of the jsMath package for mathematics on the web. * * This file indicates that no image fonts are available. * It should be loaded BEFORE jsMath.js is loaded. * * = --------------------------------------------------------------------- * * Copyright 2004-2006 by Davide P. Cervone *=20 * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License. * You may obtain a copy of the License at *=20 * http://www.apache.org/licenses/LICENSE-2.0 *=20 * Unless required by applicable law or agreed to in writing, software * distributed under the License is distributed on an "AS IS" BASIS, * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or = implied. * See the License for the specific language governing permissions and * limitations under the License. */ if (!window.jsMath) {window.jsMath =3D {}} window.jsMath.noImgFonts =3D 1; ------=_NextPart_000_0082_01C6C6EA.10068EF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.springerlink.com/jsMath/plugins/autoload.js /* * autoload.js * =20 * Part of the jsMath package for mathematics on the web. * * This file is a plugin that checks if a page contains any math * that must be processed by jsMath, and only loads jsMath.js * when there is. * =20 * You can control the items to look for via the variables * =20 * jsMath.Autoload.findMathElements * jsMath.Autoload.findTeXstrings * jsMath.Autoload.findLaTeXstrings * jsMath.Autoload.findCustomStrings * jsMath.Autoload.findCustomSettings * =20 * which control whether to look for SPAN and DIV elements of class * "math", TeX strings that will be converted by jsMath.ConvertTeX(), = or * LaTeX strings that will be converted by jsMath.ConvertLaTeX(). By * default, the first is true and the second and third are false. The * findCustomStrings can be used to specify your own delimiters for * in-line and display mathematics, e.g * =20 * jsMath.Autoload.findCustomStrings =3D [ * '[math],'[/math]', // start and end in-line math * '[display]','[/display]' // start and end display math * ]; * =20 * Finally, findCustomSettings can be set to an object reference whose * name:value pairs control the individual search settings for = tex2math. =20 * (See the plugins/tex2math.js file for more details). * =20 * If any math strings are found, jsMath.js will be loaded = automatically,=20 * but not loaded otherwise. If any of the last four are set and TeX = math * strings are found, then plugins/tex2ath.js will be loaded * automatically. jsMath.Autoload.needsJsMath will be set to true or * false depending on whether jsMath needed to be loaded. * =20 * The value of jsMath.Autoload.element controls the element to be * searched by the autoload plug-in. If unset, the complete document = will * be searched. If set to a string, the element with that name will be * searched. If set to a DOM object, that object and its children will * be searched. * =20 * Finally, there are two additional parameters that control files to * be loaded after jsMath.js, should it be needed. These are * =20 * jsMath.Autoload.loadFonts * jsMath.Autoload.loadFiles * =20 * If jsMath.js is loaded, the fonts contained in the loadFonts array * will be loaded, and the JavaScript files listed in the loadFiles = array * will be run. Relative URL's are loaded based from the URL = containing * jsMath.js. * =20 * The autoload plugin can be loaded in the document HEAD or in the = BODY.=20 * If it is loaded in the HEAD, you will need to call = jsMath.Autoload.Check() * at the end of the BODY (say in the window.onload handler) in order = to * get it to check the page for math that needs to be tagged, otherwise = load * the file at the bottom of the BODY and it will run the check = automatically. * * You can call jsMath.Autoload.Run() after the check has been = performed * in order to call the appropriate tex2math routines for the given = Autoload * settings. You can call jsMath.Autoload.Run() even when jsMath isn't = loaded. * =20 * = --------------------------------------------------------------------- * * Copyright 2004-2006 by Davide P. Cervone *=20 * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License. * You may obtain a copy of the License at *=20 * http://www.apache.org/licenses/LICENSE-2.0 *=20 * Unless required by applicable law or agreed to in writing, software * distributed under the License is distributed on an "AS IS" BASIS, * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or = implied. * See the License for the specific language governing permissions and * limitations under the License. */ /************************************************************************= */ /* * Make sure jsMath.Autoload is available */ if (!window.jsMath) {window.jsMath =3D {}} if (jsMath.Autoload =3D=3D null) {jsMath.Autoload =3D {}} jsMath.Add =3D function (dst,src) {for (var id in src) {dst[id] =3D = src[id]}}, jsMath.document =3D document; // tex2math needs this jsMath.Add(jsMath.Autoload,{ =20 Script: { iframe: null, // the hidden iframe /* * Load an external JavaScript file asynchronously */ Load: function (url) { this.iframe =3D document.createElement('iframe'); this.iframe.style.visibility =3D 'hidden'; this.iframe.style.position =3D 'absolute'; this.iframe.style.width =3D '0px'; this.iframe.style.height =3D '0px'; if (document.body.firstChild) { = document.body.insertBefore(this.iframe,document.body.firstChild); } else { document.body.appendChild(this.iframe); } this.url =3D url; = setTimeout('jsMath.Autoload.Script.setURL()',100); }, endLoad: function () = {setTimeout('jsMath.Autoload.Script.AfterLoad()',1)}, /* * Use location.replace() to avoid browsers placing the file in * the history (and messing up the BACK button action). Not * completely effective in Firefox 1.0.x. Safari won't handle * replace() if the document is local (not sure if that's really * the issue, but that's the only time I see it). */ setURL: function () { var url =3D jsMath.Autoload.root+"jsMath-autoload.html"; var doc =3D this.iframe.contentDocument; if (!doc && this.iframe.contentWindow) {doc =3D = this.iframe.contentWindow.document} if (navigator.vendor =3D=3D "Apple Computer, Inc." && document.location.protocol =3D=3D 'file:') {doc =3D null} if (doc) {doc.location.replace(url)} else {this.iframe.src =3D = url} }, /* * Queue items that need to be postponed until jsMath has run */ queue: [], Push: function (name,data) {this.queue[this.queue.length] =3D = [name,data]}, RunStack: function () { if (this.tex2math) {jsMath.Autoload.Check2(); return} for (var i =3D 0; i < this.queue.length; i++) { var name =3D this.queue[i][0]; var data =3D this.queue[i][1]; if (data.length =3D=3D 1) {jsMath[name](data[0])} else {jsMath[name](data[0],data[1],data[2],data[3])} } }, =20 AfterLoad: function () {jsMath.Autoload.Script.RunStack()}, /* * Look up the jsMath root directory, if it is not already supplied */ Root: function () { if (jsMath.Autoload.root) return; var script =3D document.getElementsByTagName('script'); if (script) { for (var i =3D 0; i < script.length; i++) { var src =3D script[i].src; if (src && src.match('(^|/)plugins/autoload.js$')) { jsMath.Autoload.root =3D = src.replace(/plugins\/autoload.js$/,''); break; } } } } }, =20 /**************************************************************/ =20 /* * Load tex2math first (so we can call its search functions * to look to see if anything needs to be turned into math) * if it is needed, otherwise go on to the second check. */ Check: function () { if (this.checked) return; this.checked =3D 1; if (this.findTeXstrings || this.findLaTeXstrings || this.findCustomStrings || this.findCustomSettings) { this.Script.tex2math =3D 1; this.Script.Load('plugins/tex2math.js'); } else { if (!jsMath.tex2math) {jsMath.tex2math =3D {}} this.Check2(); } }, /* * Once tex2math is loaded, use it to check for math that * needs to be tagged for jsMath, and load jsMath if it is needed */ Check2: function () { this.Script.tex2math =3D 0; this.needsJsMath =3D 0; if (this.checkElement =3D=3D null) = {this.checkElement =3D null} if (this.findMathElements) { this.needsJsMath =3D this.areMathElements(this.checkElement); } jsMath.tex2math.callback =3D this.tex2mathCallback; if (this.findTeXstrings && !this.needsJsMath) { jsMath.tex2math.ConvertTeX(this.checkElement); } if (this.findLaTeXstrings && !this.needsJsMath) { jsMath.tex2math.ConvertLaTeX(this.checkElement); } if (this.findCustomSettings && !this.needsJsMath) { = jsMath.tex2math.Convert(this.checkElement,this.findCustomSettings); } if (this.findCustomStrings && !this.needsJsMath) { var s =3D this.findCustomStrings; jsMath.tex2math.CustomSearch(s[0],s[1],s[2],s[3]); jsMath.tex2math.ConvertCustom(this.checkElement); } jsMath.tex2math.callback =3D null; if (this.needsJsMath) { this.LoadJsMath(); } else { jsMath.Autoload.Script =3D null; jsMath.Process =3D function () {}; jsMath.ProcessBeforeShowing =3D function () {}; jsMath.Synchronize =3D function () {}; jsMath.ConvertTeX =3D function () {}; jsMath.ConvertTeX2 =3D function () {}; jsMath.ConvertLaTeX =3D function () {}; jsMath.ConvertCustom =3D function () {}; jsMath.CustomSearch =3D function () {}; jsMath.Macro =3D function () {}; jsMath.Autoload.Run =3D function () {}; } }, /* * A callback used in the tex2math searches to signal that * some math has been found. */ tex2mathCallback: function () { jsMath.Autoload.needsJsMath =3D 1; return false; }, /* * jsMath.Autoload.Run() can be called to perform the=20 * tex2math calls given by the Autoload parameters. */ Run: function (data) {this.Script.Push('Autorun',[data])}, Autorun: function () { if (this.findTeXstrings) {jsMath.ConvertTeX(this.checkElement)} if (this.findLaTeXstrings) {jsMath.ConvertLaTeX(this.checkElement)} if (this.findCustomSettings) { jsMath.Synchronize(function () { jsMath.tex2math.Convert(jsMath.Autoload.checkElement, jsMath.Autoload.findCustomSettings); }); } if (this.findCustomStrings) { var s =3D this.findCustomStrings; jsMath.CustomSearch(s[0],s[1],s[2],s[3]); jsMath.ConvertCustom(this.checkElement); } }, /* * Look to see if there are SPAN or DIV elements of class "math". */ areMathElements: function (obj) { if (!obj) {obj =3D document} if (typeof(obj) =3D=3D 'string') {obj =3D = document.getElementById(obj)} if (!obj.getElementsByTagName) {return false} var math =3D obj.getElementsByTagName('div'); for (var k =3D 0; k < math.length; k++)=20 {if (math[k].className.match(/(^| )math( |$)/)) {return true}} math =3D obj.getElementsByTagName('span'); for (var k =3D 0; k < math.length; k++)=20 {if (math[k].className.match(/(^| )math( |$)/)) {return true}} return false; }, /* * When math tags are found, load the jsMath.js file, * and afterward, load any auxiliary files or fonts, * and then do any pending commands. */ LoadJsMath: function () { if (this.root) { this.setMessage('Loading jsMath...'); this.Script.AfterLoad =3D this.afterLoad; this.Script.Load('jsMath.js'); } else { alert("Can't determine URL for jsMath.js"); } }, afterLoad: function () { if (jsMath.tex2math.window) {jsMath.tex2math.window.jsMath =3D = jsMath} // // Handle MSIE bug where jsMath.window both is and is not the = actual window // if (jsMath.browser =3D=3D 'MSIE') {window.onscroll =3D = jsMath.window.onscroll}; var fonts =3D jsMath.Autoload.loadFonts; if (fonts) { if (typeof(fonts) !=3D 'object') {fonts =3D [fonts]} for (var i in fonts) {jsMath.Font.Load(fonts[i])} } var files =3D jsMath.Autoload.loadFiles; if (files) { if (typeof(files) !=3D 'object') {files =3D [files]} for (var i in files) {jsMath.Setup.Script(files[i])} } jsMath.Synchronize(function () {jsMath.Autoload.Script.RunStack()}); jsMath.Autoload.setMessage(); }, /* * Display a message in a small box at the bottom of the screen */ setMessage: function (message) { if (message) { this.div =3D document.createElement('div'); if (!document.body.hasChildNodes) = {document.body.appendChild(this.div)} else = {document.body.insertBefore(this.div,document.body.firstChild)} var style =3D { position:'absolute', bottom:'1px', left:'2px', backgroundColor:'#E6E6E6', border:'solid 1px #959595', margin:'0px', padding:'1px 8px', zIndex:102, color:'black', fontSize:'75%', width:'auto' }; for (var id in style) {this.div.style[id] =3D style[id]} this.div.appendChild(jsMath.document.createTextNode(message)); } else { this.div.firstChild.nodeValue =3D ""; this.div.style.visibility =3D 'hidden'; } } =20 }); /* * Queue these so we can do them after jsMath has been loaded */ jsMath.Add(jsMath,{ Process: function (data) = {jsMath.Autoload.Script.Push('Process',[data])}, ProcessBeforeShowing: function (data) = {jsMath.Autoload.Script.Push('ProcessBeforeShowing',[data])}, ConvertTeX: function (data) = {jsMath.Autoload.Script.Push('ConvertTeX',[data])}, ConvertTeX2: function (data) = {jsMath.Autoload.Script.Push('ConvertTeX2',[data])}, ConvertLaTeX: function (data) = {jsMath.Autoload.Script.Push('ConvertLaTeX',[data])}, ConvertCustom: function (data) = {jsMath.Autoload.Script.Push('ConvertCustom',[data])}, CustomSearch: function (d1,d2,d3,d4) = {jsMath.Autoload.Script.Push('CustomSearch',[d1,d2,d3,d4])}, Synchronize: function (data) = {jsMath.Autoload.Script.Push('Synchronize',[data])}, Macro: function (cs,def,params) = {jsMath.Autoload.Script.Push('Macro',[cs,def,params])}, Autorun: function () {jsMath.Autoload.Autorun()} }); /* * Initialize */ if (jsMath.Autoload.findMathElements =3D=3D null) = {jsMath.Autoload.findMathElements =3D 1} if (jsMath.Autoload.findTeXstrings =3D=3D null) = {jsMath.Autoload.findTeXstrings =3D 0} if (jsMath.Autoload.findLaTeXstrings =3D=3D null) = {jsMath.Autoload.findLaTeXstrings =3D 0} jsMath.Autoload.Script.Root(); //if (document.body) {jsMath.Autoload.Check()} ------=_NextPart_000_0082_01C6C6EA.10068EF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.springerlink.com/js/MetaPress.Web.HyperLinkButton.js,MetaPress.Web.js function hyperLinkButton_getTrueSender(sender) { var isSender =3D false; isSender =3D (sender.tagName =3D=3D 'A' && getAttributeValue(sender, = 'value')); =20 while (sender && !isSender) { sender =3D getParent(sender); isSender =3D (sender.tagName =3D=3D 'A' && getAttributeValue(sender, = 'value')); } =20 return sender; } function hyperLinkButton_onClick(e) { e =3D getEvent(e); var sender =3D hyperLinkButton_getTrueSender(getSender(e)); =20 var methodName =3D getAttributeValue(sender, 'onClickMethod'); if (methodName !=3D '' && window[methodName]) var ret =3D window[methodName](sender); return ret || false; } ------=_NextPart_000_0082_01C6C6EA.10068EF0 Content-Type: application/octet-stream Content-Transfer-Encoding: 7bit Content-Location: http://www.springerlink.com/js/MetaPress.Web.DefaultTextBox.js,MetaPress.Web.js function defaultTextBox_captureEnter(e) { e = getEvent(e); var sender = getSender(e); var target = getElement(getAttributeValue(sender, 'target')); if (target == null) { alert('target for ' + sender.id + ' is null'); return false; } if (e.keyCode == 13) { abortEvent(e); switch(getAttributeValue(sender, 'action')) { case 'click': defaultTextBox_click(target); break; case 'focus': setFocus(target); break; default: defaultTextBox_click(target); } } } function defaultTextBox_click(element) { if (element != null) element.click(); } function defaultTextBox_setFocus(element) { if (element != null) { element.focus(); switch (element.tagName) { case 'SELECT': if (element.options.length > 0) element.selectedIndex = 0; break; case 'INPUT': switch (getAttributeValue(element, type)) { case '', 'text', 'password': element.select(); break; } break; } } } ------=_NextPart_000_0082_01C6C6EA.10068EF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.springerlink.com/js/MetaPress.Products.Reader.QueryBuilderControl.js,MetaPress.Products.Reader.js function queryBuilder_wireUpEvents(senderId) { var sender =3D queryBuilder_getRoot(getElement(senderId)); var textBox =3D queryBuilder_getTextBox(sender); var operatorList =3D queryBuilder_getOperatorList(sender); var fieldList =3D queryBuilder_getFieldList(sender); for(var k =3D 0; k < fieldList.childNodes.length; k++) { if (fieldList.childNodes[k].className !=3D 'empty') { =20 addHandler(fieldList.childNodes[k].childNodes[0], 'onclick', = queryBuilder_onFieldClick); addHandler(fieldList.childNodes[k], 'onclick', = queryBuilder_onFieldClick); addHandler(fieldList.childNodes[k], 'onmouseover', = queryBuilder_onMouseOver); addHandler(fieldList.childNodes[k], 'onmouseout', = queryBuilder_onMouseOut); } } for(var k =3D 0; k < operatorList.childNodes.length; k++) { if (operatorList.childNodes[k].className !=3D 'empty') { if (getAttributeValue(operatorList.childNodes[k], 'arg') =3D=3D = '*') { addHandler(operatorList.childNodes[k].childNodes[0], 'onclick', = queryBuilder_onWildcardClick); addHandler(operatorList.childNodes[k], 'onclick', = queryBuilder_onWildcardClick); } else { addHandler(operatorList.childNodes[k].childNodes[0], 'onclick', = queryBuilder_onOperatorClick); addHandler(operatorList.childNodes[k], 'onclick', = queryBuilder_onOperatorClick); } addHandler(operatorList.childNodes[k], 'onmouseover', = queryBuilder_onMouseOver); addHandler(operatorList.childNodes[k], 'onmouseout', = queryBuilder_onMouseOut); } } =20 addHandler(textBox, 'onclick', queryBuilder_updateSelection); addHandler(textBox, 'onselect', queryBuilder_updateSelection); addHandler(textBox, 'onfocus', queryBuilder_updateSelection); addHandler(textBox, 'onkeyup', queryBuilder_updateSelection); addHandler(textBox, 'onkeydown', queryBuilder_onKeyPress); } function queryBuilder_getRoot(sender) { while (sender !=3D null && getAttributeValue(sender, 'key') !=3D = 'advancedTextBox') sender =3D getParent(sender); =20 return sender; } function queryBuilder_getTextBox(sender) { return getElementByKeyAndTagName(queryBuilder_getRoot(sender), 'text', = 'INPUT'); } function queryBuilder_getOperatorList(sender) { return getElementByKeyAndTagName(queryBuilder_getRoot(sender), = 'operatorList', 'UL'); } function queryBuilder_getFieldList(sender) { return getElementByKeyAndTagName(queryBuilder_getRoot(sender), = 'fieldList', 'UL'); } function queryBuilder_getSelectionStart(sender) { var start =3D getAttributeValue(queryBuilder_getRoot(sender), 'ss'); if (start =3D=3D '') return 0; else return start; } function queryBuilder_setSelectionStart(sender, selectionStart) { setAttributeValue(queryBuilder_getRoot(sender), 'ss', selectionStart); } function queryBuilder_getSelectionEnd(sender) { var end =3D getAttributeValue(queryBuilder_getRoot(sender), 'se'); if (end =3D=3D '') return 0; else return end; } function queryBuilder_setSelectionEnd(sender, selectionEnd) { setAttributeValue(queryBuilder_getRoot(sender), 'se', selectionEnd); } function queryBuilder_onFieldClick(e) { e =3D getEvent(e); var sender =3D getSender(e); if (sender.tagName !=3D 'LI') sender =3D getParent(sender); =20 var textBox =3D queryBuilder_getTextBox(sender); var text =3D getAttributeValue(sender, 'arg'); var selectionStart =3D queryBuilder_getSelectionStart(sender); var selectionEnd =3D queryBuilder_getSelectionEnd(sender); if (selectionStart =3D=3D selectionEnd || !isIE) { textBox.value +=3D ' ' + text; queryBuilder_setCaretPos(textBox, textBox.value.length - 1); queryBuilder_updateSelection(e); } else { textBox.focus(); var range =3D document.selection.createRange(); range.moveStart('character', selectionStart); range.moveEnd('character', selectionEnd - selectionStart); range.text =3D text; queryBuilder_updateSelection(e); range.select(); =20 } =20 abortEvent(e); return false; } function queryBuilder_onOperatorClick(e) { e =3D getEvent(e); var sender =3D getSender(e); =20 if (sender.tagName !=3D 'LI') sender =3D getParent(sender); =20 var textBox =3D queryBuilder_getTextBox(sender); var text =3D getAttributeValue(sender, 'arg'); =20 var selectionStart =3D queryBuilder_getSelectionStart(sender); var selectionEnd =3D queryBuilder_getSelectionEnd(sender); =20 textBox.focus(); if (selectionStart =3D=3D selectionEnd || !isIE) { textBox.value +=3D ' ' + text; queryBuilder_setCaretPos(textBox, textBox.value.length - 1); queryBuilder_updateSelection(e); } else { var range =3D document.selection.createRange(); range.moveStart('character', selectionStart); range.moveEnd('character', selectionEnd - selectionStart); range.text =3D text; queryBuilder_updateSelection(e); range.select(); } =20 abortEvent(e); return false; } function queryBuilder_onWildcardClick(e) { e =3D getEvent(e); var sender =3D getSender(e); =20 if (sender.tagName !=3D 'LI') sender =3D getParent(sender); =20 var textBox =3D queryBuilder_getTextBox(sender); var text =3D getAttributeValue(sender, 'arg'); var selectionStart =3D queryBuilder_getSelectionStart(sender); var selectionEnd =3D queryBuilder_getSelectionEnd(sender); textBox.focus(); if (!isIE) { textBox.value +=3D text; queryBuilder_setCaretPos(textBox, textBox.value.length - 1); queryBuilder_updateSelection(e); } else if (selectionStart =3D=3D selectionEnd) { var range =3D document.selection.createRange(); range.text =3D text; queryBuilder_updateSelection(e); range.select(); } else { var range =3D document.selection.createRange(); range.moveStart('character', selectionStart); range.moveEnd('character', selectionEnd - selectionStart); range.text =3D text; queryBuilder_updateSelection(e); range.select(); } =20 abortEvent(e); return false; } function queryBuilder_setCaretPos(textBox, position) { if (textBox.selectionStart) { textBox.selectionStart =3D position; textBox.selectionEnd =3D position; } else { var range =3D textBox.createTextRange(); range.moveStart('character', position); range.collapse(); range.select(); } } function queryBuilder_findSelectionStart(textBox)=20 { if (isIE) { var range =3D document.selection.createRange(); var isCollapsed =3D range.compareEndPoints("StartToEnd", range) =3D=3D = 0; if (!isCollapsed) range.collapse(true); var b =3D range.getBookmark(); return b.charCodeAt(2) - 2; } else return textBox.selectionStart; } function queryBuilder_findSelectionEnd(textBox)=20 { if (isIE) { var range =3D document.selection.createRange(); var isCollapsed =3D range.compareEndPoints("StartToEnd", range) = =3D=3D 0; if (!isCollapsed) range.collapse(false); var b =3D range.getBookmark(); return b.charCodeAt(2) - 2; =20 } else return textBox.selectionEnd; } function queryBuilder_updateSelection(e) { e =3D getEvent(e); var sender =3D getSender(e); var textBox =3D queryBuilder_getTextBox(sender) if (document.activeElement =3D=3D textBox || sender =3D=3D textBox) { queryBuilder_setSelectionStart(sender, = queryBuilder_findSelectionStart(textBox)); queryBuilder_setSelectionEnd(sender, = queryBuilder_findSelectionEnd(textBox)); } //window.status =3D queryBuilder_findSelectionStart(textBox) + ' -> ' = + queryBuilder_findSelectionEnd(textBox); } function queryBuilder_clear(e) { e =3D getEvent(e); var sender =3D getSender(e); var textBox =3D queryBuilder_getTextBox(sender); textBox.value =3D ''; textBox.focus();=20 } function queryBuilder_close(e) { e =3D getEvent(e); var sender =3D getSender(e); var root =3D queryBuilder_getRoot(sender); =20 var div =3D getElementByKeyAndTagName(root, 'contents', 'DIV'); advancedTextBox_collapse(div); getElementByKeyAndTagName(root, 'text', 'INPUT').focus(); =20 } function queryBuilder_onMouseOver(e) =20 { =20 e =3D getEvent(e); var sender =3D getSender(e); if (sender.tagName !=3D 'LI') sender =3D getParent(sender); sender.className =3D 'hover'; } =20 function queryBuilder_onMouseOut(e) =20 { =20 e =3D getEvent(e); var sender =3D getSender(e); if (sender.tagName !=3D 'LI') sender =3D getParent(sender); sender.className =3D ''; }=20 function queryBuilder_onKeyPress(e) { e =3D getEvent(e); var sender =3D getSender(e); if (e.keyCode =3D=3D 27) { abortEvent(e); queryBuilder_close(e); } =20 var key =3D String.fromCharCode(e.keyCode); if (key =3D=3D '') return false; =20 key =3D key.toLowerCase(); var needsAlt =3D false; var needsCtrl =3D false; var target =3D ''; =20 if (e.altKey || e.ctrlKey) { var links =3D = queryBuilder_getRoot(sender).getElementsByTagName('LI'); for (var k =3D 0; k < links.length; k++) { var hotkey =3D getAttributeValue(links[k], 'hotkey'); if (hotkey !=3D '') { needsAlt =3D false; needsCtrl =3D false; target =3D ''; var keys =3D hotkey.split('+'); for (i =3D 0; i < keys.length; i++) { switch(keys[i].toLowerCase()) { case 'alt' : needsAlt =3D true; break; case 'ctrl' : needsCtrl =3D true; break; default : target =3D keys[i].toLowerCase(); break; } } if (needsAlt =3D=3D e.altKey && needsCtrl =3D=3D e.ctrlKey && = key =3D=3D target) { links[k].childNodes[0].click(); abortEvent(e); return true; } } =20 } } } ------=_NextPart_000_0082_01C6C6EA.10068EF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.springerlink.com/js/MetaPress.Web.AdvancedTextBox.js,MetaPress.Web.js function advancedTextBox_onLoad(senderId) { var sender =3D getElement(senderId); =20 var expandButton =3D getElementByKeyAndTagName(sender, 'expand', = 'INPUT'); if (expandButton) expandButton.style.display =3D 'inline'; =20 if (getAttributeValue(sender, 'gdm') > 0) getElementByKeyAndTagName(sender, 'go', 'INPUT').style.display =3D = 'none'; =20 advancedTextBox_position(sender); =20 addHandler(getElementByKeyAndTagName(sender, 'text', 'INPUT'), = 'onblur', advancedTextBox_onBlur); addHandler(getElementByKeyAndTagName(sender, 'go', 'INPUT'), = 'onclick', advancedTextBox_onGo); } function advancedTextBox_position(sender) { var textBox =3D getElementByKeyAndTagName(sender, 'text', 'INPUT'); var div =3D getElementByKeyAndTagName(sender, 'contents', 'DIV'); =20 if (getAttributeValue(sender, 'da') =3D=3D '1') div.style.left =3D (getLeft(textBox) + getWidth(textBox)) - = getWidth(div); else div.style.left =3D getLeft(textBox); =20 div.style.top =3D getTop(textBox) + getHeight(textBox); } function advancedTextBox_collapse(sender) { =20 sender.style.display =3D 'none'; } function advancedTextBox_expand(sender) { sender.style.display =3D 'block'; advancedTextBox_position(getParent(sender)); } function advancedTextBox_toggle(e) { e =3D getEvent(e); var sender =3D getParent(getSender(e)); var div =3D getElementByKeyAndTagName(sender, 'contents', 'DIV'); =20 if (getCurrentStyle(div).display =3D=3D 'block') advancedTextBox_collapse(div); else advancedTextBox_expand(div); =20 getElementByKeyAndTagName(sender, 'text', 'INPUT').focus(); return false; } function advancedTextBox_onBlur(e) { if (!document.activeElement) return false; =20 e =3D getEvent(e); var sender =3D getSender(e); var parent =3D getParent(sender); =20 var current =3D document.activeElement; while (current) { if (current =3D=3D parent) return true; =20 current =3D getParent(current); } =20 var div =3D getElementByKeyAndTagName(parent, 'contents', 'DIV'); advancedTextBox_collapse(div); } function advancedTextBox_onGo(e) { e =3D getEvent(e); var sender =3D getSender(e); var parent =3D getParent(sender); var div =3D getElementByKeyAndTagName(parent, 'contents', 'DIV'); advancedTextBox_collapse(div); } ------=_NextPart_000_0082_01C6C6EA.10068EF0--