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A congenital brain tumor associated with assisted in
vitro fertilization. Case report
Das
A, Simmons
C, Danielpour
M
Maxine Dunitz Neurosurgical Institute, USA. Asha_Das@eisai.com
In this report the authors describe the clinical features of a rare neonatal
anaplastic astrocytoma in the setting of in vitro fertilization (IVF).
The
infant had been conceived using IVF and was born full term to a 29-year-old
prima gravida mother.
At birth, the baby boy was irritable and demonstrated
poor feeding.
Cranial ultrasonography and magnetic resonance imaging
revealed an echogenic mass in the left hemisphere with midline shift and
hydrocephalus.
Grosstotal resection of an anaplastic astrocytoma was
followed by chemotherapy with temozolomide and vincristine.
Previous cases
of neonatal brain tumors occurring in the setting of assisted reproduction
are reviewed.
A possible association between IVF and congenital
neuroepithelial tumors is highlighted.
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