From: Subject: JAMA -- Low-Dose Aspirin and Vitamin E: Challenges and Opportunities in Cancer Prevention, July 6, 2005, Jacobs and Thun 294 (1): 105 Date: Thu, 20 Jul 2006 17:21:26 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0112_01C6AC20.EE600940" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0112_01C6AC20.EE600940 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://jama.ama-assn.org/cgi/content/extract/294/1/105 JAMA -- Low-Dose Aspirin and Vitamin E: Challenges = and Opportunities in Cancer Prevention, July 6, 2005, Jacobs and Thun = 294 (1): 105

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Low-Dose Aspirin and = Vitamin E=20

Challenges and Opportunities in Cancer = Prevention=20

Eric J. Jacobs, PhD; Michael J. = Thun,=20 MD

JAMA. 2005;294:105-106.

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Since this article does not = have an=20 abstract, we have provided the first 150 words = of the full=20 text and any section=20 = headings.
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This = issue of=20 JAMA includes 2 articles from the Women=92s = Health=20 Study (WHS).1-2 This 10-year long,=20 placebo-controlled, randomized trial of low-dose = aspirin=20 and vitamin E included nearly 40 000 = predominantly=20 middle-aged women with no history of cancer or=20 cardiovascular disease.3 The WHS used a = 2 x 2 factorial = design to=20 evaluate the effects of low-dose aspirin (100 mg) = taken=20 every other day and 600 IU of vitamin E (in the = form of=20 natural-source 3D{alpha}=20-tocopherol),=20 also taken every other day. Neither = alternate-day,=20 low-dose aspirin nor vitamin E showed any = evidence of=20 efficacy in reducing overall cancer incidence or=20 mortality.1-2 With respect to noncancer outcomes, = notable findings for low-dose aspirin included a=20 reduction in stroke risk, no apparent effect on=20 myocardial infarction, and an increased risk of=20 gastrointestinal bleeding requiring transfusion.4 = Vitamin E had no apparent effect . . = .=20 [Full=20 Text of this Article]


RELATED=20 ARTICLES=20
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Low-Dose Aspirin in the Primary Prevention of = Cancer: The=20 Women=92s Health Study: A Randomized Controlled=20 Trial
Nancy R. Cook, I-Min Lee, J. Michael = Gaziano,=20 David Gordon, Paul M Ridker, JoAnn E. Manson, Charles H. = Hennekens,=20 and Julie E. Buring
JAMA. 2005;294:47-55. =
ABSTRACT<= /A>=20 | FULL=20 TEXT  =20

Vitamin E in the Primary Prevention of = Cardiovascular=20 Disease and Cancer: The Women=92s Health Study: A Randomized = Controlled Trial
I-Min Lee, Nancy R. Cook, J. = Michael=20 Gaziano, David Gordon, Paul M Ridker, JoAnn E. Manson, = Charles H.=20 Hennekens, and Julie E. Buring
JAMA. = 2005;294:56-65.=20
ABSTRACT<= /A>=20 | FULL=20 TEXT  =20

This Week in = JAMA
JAMA.=20 2005;294:9.
FULL=20 TEXT  =20


THIS ARTICLE HAS BEEN CITED BY OTHER = ARTICLES=20
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New=20 Women's Health Study Data on Vitamin E and=20 Aspirin
Journal Watch Cardiology=20 2005;2005:1-1.
FULL=20 TEXT  =20



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