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Chromosome 1p loss: A favorable
prognostic factor in low-grade gliomas
Kujas M, Lejeune J, Benouaich-Amiel A, Criniere
E, Laigle-Donadey F, Marie Y, Mokhtari K, Polivka
M, Bernier M, Chretien F, Couvelard A, Capelle
L, Duffau H, Cornu P, Broet P, Thillet J,
Carpentier AF, Sanson M, Hoang-Xuan K, Delattre
JY.
INSERM U711 et Universite Pierre et Marie Curie Paris VI, France.
Search for loss of heterozygosity on chromosomes 1p, 9p, 10q, and 19q,
epidermal growth factor receptor (EGFR) gene amplification, and p53
expression was performed in a series of 131 low-grade gliomas.
The profile of molecular changes, clinical findings, and histology
were subsequently correlated with the course of the disease, mainly
progression-free survival.
When these parameters were considered as candidate variables in a
multivariate analysis, only loss of heterozygosity on chromosome 1p
was associated with increased progression-free survival (hazard ratio,
0.521), indicating a major favorable prognostic role of this genetic
alteration in low-grade gliomas.
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