|
|
Response to chemotherapy of a radiation-induced
glioblastoma multiforme
Nicolardi
L, Deangelis
LM
School of Medicine, Padua University, Padua, Italy.
Background. Radiation-induced glioblastoma multiforme (GBM) is particularly
resistant to treatment and therapeutic options are limited.
We report a
patient with a radiation-induced GBM who had a complete response to
carmustine and survived for 44 months.
Patients and Methods. Case report of
a 38-year-old man with a radiation-induced GBM that responded to carmustine.
Results. Our patient developed a left occipital GBM 35 years after a left
cerebellar astrocytoma was treated with surgery and radiation therapy (4500
rad).
The GBM was treated with subtotal resection followed by four cycles of
carmustine; a complete response was achieved.
He relapsed 34 months after
diagnosis and with further surgery survived 44 months from his diagnosis of
GBM.
Conclusion. GBMs may be a late complication of radiation treatment for
pediatric brain tumors.
If further radiotherapy is not a therapeutic option,
chemotherapy may result in prolonged survival.
|
