|
|
Does increased 18FDG uptake reflect malignant
transformation of a low-grade glioma? A diagnostic dilemma
Novak L, Molnar P, Lengyel Z, Tron L
Department of Neurosurgery, University of Debrecen, Health and Life Sciences
Center, Nagyerdei krt. 98, PO Box 31, 4012 Debrecen, Hungary.
lnovak@jaguar.dote.hu
Benign gliomas of the brain show decreased uptake of 18F fluorodeoxyglucose
(FDG) on positron emission tomography (PET).
Malignant transformation is
usually manifested by an increase of 18FDG uptake.
A 45-year-old female has
been followed up since 1987 by means of 18FDG-PET for a right hemispheric
World Health Organization Grade II oligoastrocytoma.
In 1996, increased
epileptic activity was accompanied by increased 18FDG uptake within the
temporal part of the tumor.
After surgery, the epileptic seizures
diminished.
Histological examination of the resected tumor showed no change
in the pathology when compared with the first biopsy.
Localized temporal
increase of 18FDG uptake was not associated with malignant progression.
The
decrease of seizure frequency might shed light on a putative connection of
hyperglycolysis and epileptic discharges.
PMID: 15805670 [PubMed - in process]
|
