From: Subject: Combination Immunotherapy with Clinical-Scale Enriched Human {gamma}{delta} T cells, hu14.18 Antibody, and the Immunocytokine Fc-IL7 in Disseminated Neuroblastoma -- Otto et al. 11 (23): 8486 -- Clinical Cancer Research Date: Tue, 16 May 2006 13:21:54 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C678EB.B322AE40" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://clincancerres.aacrjournals.org/cgi/content/abstract/11/23/8486 Combination Immunotherapy with Clinical-Scale = Enriched Human {gamma}{delta} T cells, hu14.18 Antibody, and the = Immunocytokine Fc-IL7 in Disseminated Neuroblastoma -- Otto et al. 11 = (23): 8486 -- Clinical Cancer Research 3D"Clinical
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF=20 CONTENTS
Cancer=20 Research Clinical Cancer=20 Research
Cancer=20 Epidemiology Biomarkers & Prevention Molecular=20 Cancer Therapeutics
Molecular=20 Cancer Research Cell Growth=20 & = Differentiation
This = Article
3D"
3D"Right Full=20 Text
3D"Right Full=20 Text (PDF)
3D"Right Alert=20 me when this article is cited
3D"Right Alert=20 me if a correction is posted
3D"
Services
3D"
3D"Right Similar=20 articles in this journal
3D"Right Similar=20 articles in PubMed
3D"Right Alert=20 me to new issues of the journal
3D"Right Download=20 to citation manager
3D"
Google = Scholar
3D"
3D"Right Articles by Otto, M.
3D"Right Articles by Handgretinger, R. =
3D"
PubMed
3D"
3D"Right PubMed=20 Citation
3D"Right Articles by Otto, M.
3D"Right Articles by Handgretinger, R.=20 =
Clinical Cancer Research Vol. 11, 8486-8491, December 1, = 2005
=A9 2005=20 American = Association for Cancer Research

Cancer Therapy: = Preclinical

Combination Immunotherapy with Clinical-Scale Enriched Human 3D{delta}=20 T=20 cells, hu14.18 Antibody, and the Immunocytokine Fc-IL7 in Disseminated=20 Neuroblastoma

Mario Otto1,=20 Raymond C. Barfield1, William J.=20 Martin2, Rekha Iyengar1, = Wing=20 Leung1, Thasia Leimig1, = Stanley=20 Chaleff1, Stephen D. Gillies3 = and=20 Rupert Handgretinger1

Authors' Affiliations: Departments of = 1=20 Hematology-Oncology and 2 Animal Resources Center, St. Jude=20 Children's Research Hospital, Memphis, Tennessee, and 3 EMD = Lexigen=20 Research Center, Billerica, Massachusetts

Requests for reprints: Mario Otto, Department = of=20 Hematology-Oncology, St. Jude Children's Research Hospital, Mailstop = 321, 332=20 North Lauderdale Street, Memphis, TN 38105-2794. Phone: 901-495-3695; = Fax:=20 901-495-4023; E-mail: mario.otto{at}stjude.org .

Purpose: To evaluate a combined cellular and = humoral=20 immunotherapy regimen in a mouse model of disseminated human=20 neuroblastoma. We tested combinations of clinical-grade, = isolated=20 human 3D{gamma}=20 = T cells with the humanized anti-GD2 antibody hu14.18 and a = novel=20 fusion cytokine, Fc-IL7.

Experimental Design: 3D{gamma}=20 = T cells were large-scale enriched from leukapheresis product = obtained=20 from granulocyte colony-stimulating factor=96mobilized = donors. 3D{delta}=20 = T cell=20 cytotoxicity was tested in a europium-TDA release assay. The = effect=20 of Fc-IL7 on 3D{gamma}=20 = T-cell survival in vitro was assessed by flow = cytometry.=20 NOD.CB17-Prkdcscid/J mice received 1 x 106 NB-1691 neuroblastoma = cells via the=20 tail vein 5 to 6 days before therapy began. Treatment, for = five=20 consecutive weeks, consisted of injections of 1 x 106 3D{gamma}=20 = T cells weekly, 1 x = 106=20 3D{gamma}3D{delta}=20 = T cells=20 weekly, and 20 =B5g hu14.18 antibody four times per week, or = 1 x 106 3D{gamma}=20 = T cells weekly with 20 =B5g hu14.18 antibody four times per = week, and=20 20 =B5g Fc-IL7 once weekly.

Results: The natural cytotoxicity of 3D{gamma}=20 = T cells to NB-1691 cells in vitro was dramatically = enhanced by=20 hu14.18 antibody. Fc-IL7 effectively kept cultured 3D{gamma}=20 = T cells viable. Combination therapy with 3D{gamma}=20 = T cells and hu14.18 antibody significantly enhanced survival=20 (P =3D 0.001), as did treatment with 3D{gamma}=20 = T cells, hu14.18 antibody, and Fc-IL7 (P =3D 0.005). = Inclusion=20 of Fc-IL7 offered an additional survival benefit (P = =3D=20 0.04).

Conclusions: We have shown a new and promising = immunotherapy=20 regimen for neuroblastoma that requires clinical evaluation.=20 Our approach might also serve as a therapeutic model for = other=20 malignancies.





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF=20 CONTENTS
Cancer=20 Research Clinical Cancer=20 Research
Cancer=20 Epidemiology Biomarkers & Prevention Molecular=20 Cancer Therapeutics
Molecular=20 Cancer Research Cell Growth=20 & Differentiation
Copyright =A9 2005 by the American Association for Cancer=20 Research. ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://clincancerres.aacrjournals.org/icons/banner/title.gif R0lGODlh3AAsAPcAAP////7+/v39/fz8/Pv7+/r6+vn5+fj4+Pf39/b29vX19fT09PPz8/Ly8vHx 8fDw8O/v7+7u7u3t7ezs7Ovr6+rq6unp6ejo6Ofn5+bm5uTk5OPj4+Li4uHh4eDg4N7e3t3d3dzc 3Nra2tnZ2djY2NfX19bW1tXV1dTU1NPT09LS0tHR0dDQ0M/Pz87Ozs3NzcvLy8rKysnJycjIyMfH x8bGxsXFxcTExMPDw8LCwsHBwcDAwL+/v76+vr29vby8vLu7u7q6urm5ubi4uLe3t7a2trW1tbS0 tLOzs7KysrGxsbCwsK+vr66urq2traysrKurq6qqqqioqKenp6ampqWlpaSkpKKioqGhoaCgoJ+f n56enp2dnZycnJubm5qampmZmZiYmJaWlpOTk5KSkpGRkZCQkI+Pj46Ojo2NjYuLi4qKiomJiYiI iIeHh4aGhoWFhYSEhIODg4KCgoGBgYCAgH9/f35+fn19fXx8fHt7e3p6enl5eXh4eHd3d3R0dHNz c3JycnFxcXBwcG9vb25ubm1tbWxsbGtra2pqamhoaGdnZ2ZmZmVlZWRkZGNjY2JiYmFhYV9fX15e Xl1dXVpaWlhYWFdXV1VVVVRUVFJSUlFRUVBQUE9PT05OTk1NTUxMTEtLS0pKSkhISEdHR0ZGRkVF RUREREJCQkFBQUBAQD8/Pz4+Pj09PTw8PDs7Ozo6Ojc3NzY2NjU1NTQ0NDMzMzIyMjExMTAwMC8v Ly4uLi0tLSwsLCsrKyoqKikpKSgoKCYmJiUlJSMjIyIiIiEhIR8fHx4eHh0dHRwcHBsbGxoaGhkZ GRgYGBcXFxYWFhUVFRQUFBMTExISEhERERAQEA4ODg0NDQwMDAsLCwoKCgkJCQgICAcHBwYGBgUF BQQEBAMDAwICAgEBAQAAAP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAOUALAAAAADcACwA QAj/AAEIHEiwoMGDCBMqXMiwocOHECNKnEixosWLGDNq3Mixo8ePIEOKHEmypMmTKFNaTEOO3I+E qMihAhCBmkwAPVqSezNBRa2WNgDEpPYAAayWajaMeAkAzJwEAFxYIzcKQJ2WPgx2IkdNQsIaiTgI jEROWgMHNsnN4bBhUssbAEZEIzfLhoQdLADEIYcNB4AEwMiZAWCHnDhyrGZxMRjzlg8hl1oqEbg3 lwYAFYKRiwEg8rUKAGwMGECKnKQDob81cwAArNgGucqetTluW6pRBP60hLSBw5IBEaa1XNv2bcQO QuTIESI2qg8XAAjkeE7Th48PAyNYx+7CR44CAzkI/7HDhYMAAA+8jLkAoIOPHxU4WI+gkMAJJ3XO 6GAtkMkcuABMx4IA02EnUAEFEhQDF3b8QJ9AB/wwxxxDsAfAB96Bh1B30AnUgBg7ZHAeABc4YYcc Q1AwkAxsrMEZQSVsYccZOwwwkH8qALCAdQNO1yFBDuwARxcnFCDddQMhiKRKTDbp5JNQRinllFRW aeWVUo7R0jN/BBGEHbocIdRNFshCjiEBLFQAI+TIYsFEV5GTlUEXxNISL2r44EQhumxwZUzF1FHH KS0NgqUEwtUxkQCpkMPNCwjFNFNwN+VEjqIC+dCSojFNM8AZ5GwDQkFtkANODwLZOY0Ae8lpkAXS kP8TDAMHSYANOXcIZERLORiQ6ECIqhXAMOT0YuNAHnxDDh8HXTWNV5HeBECj0EwAAArhuJSQBqG0 BIQU5FhDa0E3tJQrALqR06twMwnkRUtWFBQspgDMi+W9+Oar77789uvvvwAHLPDABBds8MEIJ/xk iXqccooeQSgAQCfTdAIAA5UgswVDAbDBzCAITMTGNNPkoFCMhKSySRwraFglFoLGHAS+EQwzDRsT DRDTMxhEOxMBNciQl3Y+WLCAFHicUcJALMhQg8sXDJHHGCgc+4ARf3zxolVY0fkMOanUZ0MZfQgx rpIXCDCEHXPUYBAMXOjxRHMkRvFHHSYMhKFfEqb/kCZBkg60BjnZWCtQCWD80cbSAx2gRB9woEDA im5kbaFABNjQxhs7hAyAkjly0cUCAiHAgxxszHAApWuozXYKDr1LThIw3UTpTJbCMdAOLdkxpqdl kHPN5QRtoQtXNlHDatcFUSJ8Bgr98MlhybSkg6/k6C4QBLHSEYAw5MTyt0AieEOOMbKk/zU4yw9f OzWpVD8MagDIcBgv6cvytSwA8M6XFwJhyTdmkT/z+UEg0iOHN5hhPezFYiCyExNBgqU9AHCPHL5r CA+60ZJZDMIOm2gGE8Y0KZvgblMD0dSlxkQN+iiiJZpYAhP+IABAkGMcg/BCNQ4jDQDIgXkFGcAL /02FijzkgRXJ0EAGzPcKJHxCJzQwgE3oJYEposdO0cgTGNYAgBbMRRp52oIrzsC1rtSuXQBwyzdo 0MW52GILPthCKmgwAE6UQQNFAAcGAaAFGDrBB29QxQKQ0JJWUOEXUJSitATSR3LYoglAAAQJFmBF gVRxhQrLpCY3yclOevKToAylKEdJylKa8pSoTKUqV8nKVrrylbCMpSxnScta2nKVDZBAAwYyrobw ZyIJkIAEXHbLjQQgAhKASkXI4Ayd6GQRAGAFYgCgwmVMTiEROIyrJHKHljDFIA8wBAedSY4rXMlM 5BTFAw51DVxRhActiYWfBjKiwH0OBg+BATEhEv+nORWkES1hBP0wh6WYlGIghHLGLq1kL4nAoCUH 9Fm9tEGOVwDgB/H0xTi5gYg0vYIc2rAWBRoBDZ08AwIDAAQ1knGLlqiiBVzbJkFANQ4jJEQLxsDG LJpBDmBMAQAToKgsdqGslixiRDDgREsOEwoBDCAPc8EFMcJBCajogRzTwEMHrzmQmJhiIKAgxyrA M4A/jEMbt4hGOPogEBbYghzP+MU1ZIAZT5BjGbcIxzOiwMic2mIb5PDFT4Na0Ue0hAgAoIMvnAkD BAjnFURtSTcQMSKF8MF6Z6QJu3DSkkkMhJBq+V0BiNASLiJEBmqoBlaXJ9OBfFQa61zIBpzQLXL/ 2AB7nhVIBdo5BwA4wlEhIAgDGKiIgexFFgGgQ0twBoDxdZWc2ECDQBjAUygYlxyBAIAlyPGNnwrk oduAnkAatQSCkEALvQAK9rxhMgCEQI+bkJdwcosZ3jKEBHqkRGZvx1lMUhOFnRLAVaKxUGCNghzI YMICDryqVvlzIFloSRcSclly9KEEOOAV9qgoHDgI4FakKIgK9HiM/LkCFZ0IwA+lAYHanaK/mBpC S3phYlQAQiBEUEZLEgGAPXCXFvlbBSqwUMOWtAEDbtCwcF4skD4YZ4K/smSUFyID4ehiCBO0UeD4 ayl6qZBTWD2A/6BJEFVwJWQ5MF+DgUgQH5MD5hMwHQhoLBWUiSnZv/YSBDnCsQOCHGAW5CgG7Ari LGgdxJ42MN+NDQDoUbQYIRygKCgw0E62FqQwtgUABYpxZzR+oJ2xeJBAJjDlhjaEBqYArE64oQYA fNSiEqCoRTFKDj0MBAgtsfVHQyoQQUylJd8IgQTsRI5qSEGp5PBAq4CQECroYhzOdAaqDqGTTCih JWEoAEVtPeptC4QConBmL6AyA1448xqDuSqvEfLqgSShJZ2wkRGaaVIdNMDMOlHEseQwzg5uQABs akkc3oBtbVe0IFyonk6qYHBuA9XbxYy4xCfukIAAADs= ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://clincancerres.aacrjournals.org/adsystem/graphics/1147778491088/clincanres/Tumor.gif?ad=11122&adview=true R0lGODlh3AAyAOYAAAAAAP///2S31F+sx1aXrlKOo12VqWicr3OjtH2quoixwLPN177U3HLY+nHW +HDT9W/R8m7P723N7WzK6mvI6GnE4mrF5GjB32e/3Wa82WW612O20mKzzmGxzGCvyV6qxFylvlqh uVics1STqJO5xp7Ay6nH0cnc4tTj6N7q7unx8/T4+R9lMy1vOzx5Q0qDSxtkGypuKjl5OUmDSViN WGeYZ3aidoWshZW3laTBpLPLs8LWwtHg0eHq4fD18FiMU2aWW3WgY4Oqa5G0cp++eq7IgrzSisrb ktjlmufvovX5qv///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAEAAEsALAAAAADcADIAAAf/gA2Cg4SFhoeIiYqLgkqOj5CRkpOUlZaXmJmam5ycjJ+goaCdpKWm p6ipmKKsrayqsLGys6iutreItLq7vLq4v7+9wsPEmrcOAhwRhBMcHBCIERbJERfOHAIWosXc3dy3 AyUmB8sNGggmJgOFEBwEBwniBwrpJiUJBR8Un979/rS2OpAIECCBNggiUhAsMMhBBwMmVBAMgOLA iokTGSAYAE2RpB8sQobcNYTFj38hjfzr5EqDRYIGGwwwMZFhgwogSlxUUQJBgRAdRhQocIAEionq OuaKBFIkC5ImUbJQuXJTK4QKYVrYkAAjQwwGThA0QWDDBEMRMoQYOLaDx0kp/5UcMYIkiRGVSOja dUQXkpEkjvImQYLEUcmTeetS7avkrtzCefn+zXtE7uTKj5BgVhJXieZIf40cyatyLuHCxVrNDCC2 YAUDKlRkLSAhxNEAJDgu+sCA4AoDDxJRigtyiJGRJV+0YPHiRdwjy1kMUXJYuuGoyZc3jxuyaZDu nKceVgLSuXUl31m4KBw3/XrPLtSbLDKyeIsWqIex4hqAAc2CIIiVwG0FDLAAQQuswwgFB0wU01KS ECfdcU+VxFxILiwXhBLxCRESEhaeN56F5mXIwoYYRmceEimNB5ILQLDQghJEqBcjilPVCOOJ6DHn 3EnLUXhESJsJI8prsUEE0/9AJti2EAK+GSABKAUgxYFwcE1F3oTIRdWiSUM+VVxJ+D0yopfioWnE eCl9eVJxFCoRo3EyhmfEnMfNGF8R431X40lEEPFNKAEGgAAH/5GwQgoiOBlAAa0t4EEoVRJUggBY RqglnF2e5GacY0ZlJnZqspmmp1O5uSWdYnL5VEqcvnoqjSad100oAgWgDqK+rXCABo4aMBECZ32i QVcEEZtpJBIKEaepa5rEIgtJOEfEeKOeBO22aobEZ1Sx9igEfS7Y+d246imx3LVRJSGSSkJsmJqx FjHazn+4ueWoAjWBooEBWTH6lqbwyhhfhaVG5VyMLSSB7XXaJoxqtBM7Z+L/m64qQV8Lxdm5ccff 3ScqSDNSSJV+jGDlqwYN8MoaCII4+h8KISBiwc0WcCDCAVmtgADLy0ISFxIddmrneEfE+EJlD1NH 6sTcTlzEfd9hzKphGQrhSFxDZO1IEj+08ON1QChR7QuAEfPJaiQMNdR/+Lh928w1szNAAngnYEJW /Rng1sBVBU7JdxtWy0IR/jDCH0aMNz4WQTQb4jJGKZRwgD6MCK65Xy40pdLYp9RVyiIUwKZC3ngf aCnqWdFtiAUJ0MO3oX9nnuVTl3RcSdqx8F6J7kp4aGN+kkzNHOLB/+D7JoCxWC4pu/WWwAY3Y/CS Vjc7ytajh1hgjQi9+fYz/z+ShMlCkZMAD9oLJ8GCRIyYAP/ics9rsrwmQbSAVwtlQ59IB/xKkCAg YJsVtOZBjmoQQRSAgURQgDcTSYEBgAa4R+iIBYKyS2X+AomOOWY0ZvvOCzjYGN8dwS54mUxh7JI2 CzHmM5k5gvykMy3MkFAwhDEbB+eShBP6ZXl0CdMQTngX0lgGNSSURCKstygRTEkmNBGHVmJGoNZE zoEJiaAI9lFBR3jIQ9M5joka9oiOhcQ8d3GKEYgQHUFt6WBOK455rOOUIYDtjICpkYxsZcYctTGO 0mFjusojo8oIEoOOEOQPmmISCtGnVUU4pBsjgQgCosBnQDvHy+CmjQY4qv8AyAqAAmp3iH/xjQEf UMohJuEc+pyEQvnjIx1NsrAkiPAv67oPrfjXpZAMYQjfYgGIUjJMIHxnOtrxZRlP5KGG5XJGIRrC coqAuPLU8pmNCUkQiCDEuYzkQyFJAjaVeIjVlOBvEgDYb1yGQAIZyDe/UsQ5LjIWBUFIaMKsE6hk OR1VjadGI3SOEc71LBkVJmnvihOHpHOYMCFhhiIJFHOMIFAyFWY5QABMcTYGUIpOhXCPiMs+XdlR gZKzEBuA0glA4ABBvDMBHWBnJz8pgSwGIAUI6EBLEdEBKE0kN0HLpgssZJf68PNoT3OaGsM1HiQs R3hpxJ1TGmnU6TgCJD//GEJhQqQqWjFnVRTi6lSAJ9IuzUmsJ3uEIZD0mwoIAoABEKBMqbgQcxjg NisoAQE80ElDDGB7BelAcAwhCbTu06qrQmrEXkArF9zlLzcqaMQmRiHAxMc4opnWHRELPB091mGi akyQiqMjz97FlqH1VjafMiTnHMG0SVSrS4dyALEsoAAgqABYmjglmQ6gALAhiAFwi4EQ4EsFC4ib PQexGt+QYLgjIKUk5gTWqi6zn7PSI9owOgSt6RGO/5QRVKflgiOQaQhBqEx8gLAcztpKnCwAQnfj eFVpCpNkGoKvfLVGoaEutAVEUOhyZqTf+ZJzAj5l3EoLOL6WcTLBGFkp/wQGcIAF0HMiCrgAOyDI uBWMgBCS2FPwTnTY6yo2hC0oF0JbIC8PNYW+I/6BSbvWAqbFZ4RyccGO3ItYuTBsQ+O54w+qyRyO AWbF8iqCc7SmZAwq9Dv9Q/IkBHEBetSjHgeowAFMMMpBwC4dB8gACa5cDwO4tQES8MAIECAOEwDV EA8c85VzCmLB6Whz6bPVrah8jT4vIwIc0DAhcqaMBmSgz9dQpSAmkAwOZEARh+5zsQYROI61F88f 0fOggMHpV6yEaOrpMaavqul5dfrU5Bu1qquC6lYvYtWw/oerZ73KWNuaGzDIta53zete+/rXwA62 sIdN7GIb+9jITrayl//N7GY7+9nQjra0p03talv72tjOtra3ze1ue/vb4Na2DG5wgxnk+gY2yDYO dmBuZcfABuSmga7fje5e04Dc8c72DnbA7HGTWwbApvcN5J3rGJA73QU/+K5rkO9r04AgPch1APiN 7R0EgODJpkEPdtCDANQABjHggQ8sjgNe3yAAG+84D2JwbYIw+wY82IEPfABwX2uc4x7PtchJrvOR B6DkMMjBxHegA2w/3AcBuAEMJp5rGuSA6OmmwQ5yAPKpg/wGRP84DHaAgxrgAAczsEEOcmBui99A BztQOgxksG6yw2AGO4A3xQvedKafXOk4CADLdX33XOvg51fPesL3/XH/tk/d3HCHdw5uMG4d4IDl BLGB4NfednNL3ulApzsM+u7rvT+c3zYAPA8CIIPQl3z0MphB0rf9cBx0XAZMr0EAeHB2wL8+9EoX OcMDkO4AjPzvE/+7D7Y+e5gnXQY+4IHTSX/0tPv67x8/+g2QjvHNrx4Gn4eB7k+e7tEvvgbIV77Q ZXD0HIw+AOYPQNEJooPpB2AG4V/+uH2fA63vOgY9oLmwoW99pVv83qv3fyenAz3QAwhnbQ83cBPH dP8ncQFgfTigAz4QA81nceund0uHgS7XgJ93chs3egrIA533d1SXazXgeONncRfHeaGnAxWoftl3 bii3AyD4cCJog9jH/3Qu138eSINJd3KZt2szMHoHOILoJ4P+t4IBqIQ5oHGk53CrB3z8dnJNeHL8 FgM+kH9Kh4U+gAPk9nE7GIYPaHFNKHQK2APkhgPkx3S8NoQwSHA2QAM1MHJvRwM0YHDoRwM2QH1c 6IU3UANcGIcz8HBoeANqmH2IqINJRwOjZ4col4bzp3YLh3QDZ24Mt3e55oYuKG+wtwM0kIVrN3Gf GHGqhwMaN4FQuIVIR3E30HE+kAN7J3RP+HbA1wPmJoYOSHzuB4swUAPnd4NsuGsnhxG51nHq1258 hxE7oHUzUIuIp4Il54sEAYz8loj8NntC5wNqJ42z13+9poIEwW88EDNxwsg454Z0tniOKNduezh7 9hdu8BiP8vhrsFeE83iP+JiP+riP/NiP/viPABmQAkltgQAAOw== ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://clincancerres.aacrjournals.org/adsystem/graphics/1147778491088/clincanres/PanCan.gif?ad=11099&adview=true R0lGODlh3AAyAPcAAAAAAP///97i2y1Wcy1VcixVcixVcSxUcSxUcCtSbipRbPL09i1WdCxTcCtR bitRbWKAlm6Im3uTpbC/yrzI0crT2itTcCtTbytSbSxTbzdeeDhfeTphfDlfejlgejhddzdcdUNn gEFlfURogENnf0drhUZpgkZogEVnfk9whlV2jVR0i2GAlWF/lF99kWKAlWB9km+Ln3yWqHuUpnyV p4mgsIierparuparuaK0waO1wqKzv6++yL3K07zJ0srU29fe4yhNZSZKYExuhFNziFp5jFx7jlt6 jXqTo5WptsrV3Nff5OXq7SdMYlZ2iVR0hld3ill5jFh4i1t7jmOAkWB9jWJ/j2eElWaDlGWCklx6 iW+Jl3ONmn2VoWyHlHuSnIGXoISao4OZooecpYabpImep42hqX+VnZKlrJaorp+wtZytsaOytau6 vKi3uaWzta68vq27vZSlp5inqKKxsqCvsKa1tqq4uae4uJ2trZuqqq66uam1tLXBwLnEw6e0sqaz sa+8urO+vKKwraSzr7/Ixa65tbjBvaq1sLK8t8XNydHY08rRzM/X0c7Uz8PLxL3FvrnBusDHv8HI v8nPx73FutTZ0s3UysvSyMnQxsfOxMXMwsPKwNPa0NHYzs/WzMvRyMrQx8bMw8XLwsTKwb7Eu9zi 2drg19je1dbc09Ta0dPZ0NLYz8/VzM7Uy83TysLJvsHIvcDHvL/Gu73EubrBttHYzc/Wy83UycnQ xcfOw8XMwcPKv8fMxMbLw8LHv97j293i2tvg2Nne1tfc1Nbb09Xa0tTZ0dLXz9HWzs7Ty8zRycvQ yMrPx8jNxd/k3L3DucnPxcLJvcDHu77Fudzg2dvf2Nre19nd1tjc1dfb1NHVzs/TzM3RysnNxt/j 3N3h2sTJwMDFvNHWzdDVzM3Sybm/tMjOw9TX0dPW0NLVz9DTzdrd19TYz9bZ0s7Ryt7h2u/v79/f 38/Pz7+/v6+vr5+fn4+Pj4CAgHBwcGBgYFBQUEBAQDAwMCAgIP///yH5BAEAAP8ALAAAAADcADIA AAj/ABMcQIABQQYMChQYGFDgAYIDAjNATKAAw4MHFA88ODDgAgIDCTwaLEjwwMIBAwcMIEDAwAMC KgcYKNASAQEEAh2qxGng4IOKBxBeIFCAYoadCGgSeHBhAEUEKGFmSLASZ4KQGAxcADlAyLZ01oBh MwUOXTFh2lBZs5StWDZkliylyyagmDZk2rChS/Y1LjJk1gQAQ3UNWDAB1U4VqwasGrJtlqyBExAM HTpj2U4de6yNmCVgArSZEkDaWrptxQ4DA1eNNGbK1rBZKnZNcDUDCDBCTEj1wtWOCqASyFDgQsKE DxUUGHCUwFXnFx4UmBpz5fKYBpTH9KiSptWNKg1g/4ie8IFEBU2XKqA6HOkABAoPrG8JMyhOnAUt FpiZAIFXusGEJUA6lngWjGzXoKNXMcVEVk1cydCFTToEpjOMZQJgIwxZwIBmmwBo8XWKNdoIhs42 eM12TTpwoROMNoUJIJk1yKBzjWqlgSNMa8CY9hcyxaACzgW+7bZeAgTI1xwGCRx1lUYJNYUTSh85 dcBNGDnXXHXVLYUAVCoRYAEDM713QVYwOXfcAxbp9J4C5hHAQJgwrcSkek11Z1F/cF4k3UoJFNDE NgqCsxgwtGVjTTBsrZWNJSsClg06wsBljWTB9GgKOsT0GNhqpFUDDmjFyIYaZYghk0wyyGRzjSXH 2P+YjinXiGrNYth8Zcyo1bS2KGmCtYUKKsVAJoB5F/EWE3zXXVXRRQitl1R/732ZgQEEXAARcVkV x6VMC4XUJZg7ZWDeUBD9dJxCBST105VpznQdQcFlENxOZ66HAZMJYRATkl7ZOJlg4FhijFrAXKNN NnedhspqcW2DDTbagKZNNdZsc82opClma2uvFrxNiQIYuk0y6ABWzI8r0iVjMaRZkowlp4CGDSqk rXYKOOAQc/CDhFpDEZxX7Vcck8uqy9u+ShX0XqAL3WSQtn9iB+aXzPl7004ywYQTU9UVp61WMIG0 HnYFXBdTtsGxeRJDTPqmLrmBDsqWJZPZnMwp2Jz/0tY1X6WDjqc1gpVzhtVoQ2BYmL6IDbC9VpNy MYFZ8yiuJGpTDDosWgJsMO5go+qip4h6mGDwCEMiaJYsbAlgQ18U6AXtKpCB1+Jd9dNVCOQpUEe4 4UaVRv291GWdO1FE1dooSfQlBsib+S18y6s0FENXq9RmvWtHq+y/BQRR4+vCgCiZJcNgc6k2nBcD FjjZZEMhMsTESBo46ZQIcfn3w3+6Z/TjnwDStxqzyM802yDGIuIAB0VcIxtfoYwwIgMswQgAFcjA xjAahIphbOMUCMFAAEZIwhKa8IQoTKEKV8jCFrrwhSy8ShMIJKPDxOYIRihCEbpQBkUcozOPU5QG /99yCkuMRkbXAMwA0VGga1iuZNnwECpOFBZtBEYxm6IZ59qABiDFQSVmAMcx1nEMbGSqNaH51DX4 YglUVKMYxzhNMQZygBHKAx94vGM87lGPeeCRhPegRwACWY96DNIe9MCjPQJgjz8GwJDxyGMi8YFI Sj4yAPQwZAD8iI9N4jEeftzjPOgRjz3uER/3iEcA4iFIPOJDHnxkpCXlMQ9TjvAe+BBkIxdZD3xo coRnaoIxTjUwAahkBF/YwABSsI5tpEIY2KhNMRQDmNqQRjafyRiKEogx0gQojdaIEIhElURrQFMt KimCJdTRCDi0QRHCYAU3iEEXD/VoMqZhY6+wgf+xlJ3EjgHghyABEIBcBvSX+WglPRJJj33QQx70 4Ic8GjnITQJAHgd9ZSJHKdCA6iORJOSHIf0Rj3rsI6AoxUc/4pGPgtLDHv0YZEzlwY8A3HGh+gjA PhAJgHTUdIS5nAcuA7pQfBCUhBm4QBCKkYzYPI406VwGF1Rih0AUQZkduIIgioEGKRwhDSMYgBH8 oI5imCEFKpHCOtAwBSOAtQzFKANaB0CFPoAjGGk4wjG3wAhBGEElG5DCHvpwhCKgYRiU2EJYO9AF ntnwFB7kSzHAcStIaeMYPRlACX8KAHx01B85BapCQaqPk0a0oPaIBz/ioQ9/dJIf/TAkSOnh2oL/ 6qMfnRwhaAMQU5TWtKaU7EdLDUpQf/hDkD/N5R/xSI97GJeE+NBHIw2JSnr0I7QjhEgQwhlN1pBF JVGQhBNU4gdBdEENakArCVAhBpWkoAsqwYIr4EtXNohBGe0dwAa6EIcyDGAEavDvBhhhjTSUwQ5p UOYWCpFfEozhEG9QyRiKMQQJvwENVtzRMYhxIcEFKBsFY4swiGIAEs5jpfG46E4XAIBUjpAf+ajH PfTx0eaetB4rpW09ADCP1frjxPWQ6IwfKdx47IO1mowHSQOKj3zcIwD+uMdJ9TEPe9RUH3jMhz1i fOR+zCMA0pWHP4I8UXuk46gBcDImY7vSGfPj/8nZTYAwk1EqAfgNHN/6wiseIYYtRIEEKmkFGFRy B2Kk9RXKHAIomLEMVgx6AGigc1i3YIc7gHEViigDFaSgzCKkAhkqccIlelEHlZAhECr5gipWcYxV DKOIxsiYNliDGGuYoldxuQkBSAjRUpKSHrX8hSBHuFBVzgOjmLTjsFkpD1piktnNHqVNgc1KVapy laQkNrKrjUmMYnShGD02K7u9yS9zex5fXoCJvzztEaI72SMEiRBYhA4B8UwlQ9DDHKDBCUloYABW eMMWVOKKM1B1HKEGhUqgQI5ltMLRKsHDNlihEhIUIQpOgIIZ7KASMNShwlJ4BcUH4IRwhEMPKv8R Q6kHAAZksKITqigGMdaBjGqoBVgbLJUVwWGTAvzg50r4QQV+oISi/5zoQUe60YV+dKA3fehMX/rS K0D1piMd6EVPOtSPvvSmd93qQh/60IMO9apn/exoV4JLmuBBS1QjGK0xRVrFAQ1qcCIPKinDIyo8 gGh8QSV0eIVKniAKKgCeGXtwhsEH8IZWuMILAyABH5ZxCDm84tGC4MO/nzCKTeA7EpCYg0rOEIp/ i0AQywjEJ1axinWkgx3D8FyG0oeNUlF2IEk5QAa+tB61fQt77ylAQdrVH4IUHyMHkUkBDnClkBAg hCF5yEZ6vrWV+IY7D6GTfIb/G54YACRWMf7/spz1O2xx6QDLpwkGghAMvICoRKdI6yZgIY1Y0KIK KtHAeAcAjb8PIA+aMHilEAlPUB2j4H91oAmaIAmQVx3REAkigG8R6ASbQAtfABMFoAdy0HGaMAgR uHCaQA7I0AqzYQrIoDCpkSGKEhlJ4XNK0AM7kABVszZQwRFc4iXM4RD2sntT0R/VAzdbYQBIQAFJ MAFLgCTjYQAmwRBOMR288xDToXsGAScFgANMwAM/4AEGwRFT8RH4sR8o4SxXkyY2KC8wIWfFUgzA QBYCYArZsAqvsAucwAu8AAuaIAh1wAmywAu7UAvmwAmbwAmzUAnQAA28UAqzAAl5AICjIAuS/yAJ k7AJmpAJuxANdVAHhAANsjAKmXAHhjALscAL0DALtVALiCAHcpAItQANuqAJmwANsJAIecAHmYAL 48AKyrANbaE+NNMgpfIoxvQlSYADBLAACWADHDAAKjADGcABExADA4ADOKADOBADPaADKoABEzAB PsAkNYAASLADPrADO1ADPoAAK0CNFHACGZABLFABD7AQOSAdSUAVOMABCPACPaCMO5AEPlACPpAD OGACPZADNWAR1wIDP4AAE1ADAzABOTABD2ADOzADEUABPLACBxADK5AAMFABz7gS0iiQMaAEJVAC PQCNGCAE2ZAMx0AbMnIzqvAKm1CTk4gJuP+ACc6AiNBgDrVQCbwgC3NYC7EAC0QZC7ogC7KgCbrw iI4YDZmQCZrAC+fAC0RZk9GACaJAiJVAitAgDqWwitBAC7qQC7oAi7PACbqQCa9gC8rwCqJhCfxz K+mQOLNmDUYjjRtwhEAwAwMAAQtAAwSAAwNwAxDAAAwgAwNgkj/wACyAAyWQARuwADHwAQlQAQpg Ai2QBBygBB0BAyYwHTkgAQjgAESSADOwAApwAEqwBB5gAErgAUuwAR6pAjjQAiZwAD8wAEuAAumh kA+5AgSQBBCghUuQAS2AARXwAck4ATzgERWQAExQhQ45AA65m4upPUKwRq3SGnKRDZ+GC6D/sAmg sAyvcAnRoAtpWQm1MAuyAAutyAu0MAqwUAmlUAmyMAm8gAmaAAuwEAtC6QxsCQrRAAuloAvRIArN gAmZMAuwKA2wwAl6uJScUAmcAAqjYJ+xMJWaEAq20HDp0CCKAQ7XAE2zUQ1oYRCD2ZAmEAE1sAR/ GQNMYJvZeRMLsQQSgAOO+QM5MAAS4I9fgpkIsJktgAPikSYF0JAyAREHwAM5gAQXoAQSMJs/8Jj4 kQA4kAM5QAA/AAE+cC8ZAANMMAE/wCRFmAQXkAM/AAIKcIUrwAE6MJsIUAEs0AME4JngMgBMII1M gBIrCUGRkRo8gw1usAVoFVh20ArIQA6+/9AMoAALsrAJmAAKmDAK4TAJo8AJpOAMTBkNoxAKmuAM o5Cp4dAMruAJn0CTkgCIl9AKrbAMiVAFFSYCTiAHpDAKclCAIuAFhxCJaQAFkecFioAM7+AHhvpf XaAhlHUKKYMO9CGNQcEDOLAERAABEKACTLCPVTocHsCb1PgARdoBA9ADScAEJ/AA8DikSbACSjAV BrABUzGlG2ASRLABP4ADjbmbMtADSqACSxAUCvABOPACJTAAPxADP2CZz9cCP2AAOIoAOMACJ9Au OZAEClABIJABNaCmMzCnNfADBJCSH9GtePoD7YIBTYANKNMjlhAMweBfkfcFYRAFeFAOf//RDOTw CqPgC5RQDuPwCq/gDM7QCpTgDeOwDK7ACq8wDuOQDMsACs3gDK+QCqzAerbgC6HgCVXLCuWgCCTA BVzwbwNwCHg3AGYgBQDnCyt3tnT1CoegTFigBmmwBkFCOceAItlAFQigA+d4Aj4wAPsaAzqgjAuA jkwQAxAAmTCqBDYgAQ0JAT1QABSpAEDQrTGwAw/JA0VaAkWRpEsQAyzwA0kQARnwAy6wBM25m9wI A+uqAzWQBASwBCaABD9QAgQhoxxQAgtQA9JqAwWQBElgAyAABDDwogdgAkywAUygAREJAUxAAxAw ARwAoxmwBAW7knuBDmRhCsHgByoRAoz/QA6g0AmdgAxoAKwDsKuP0A5fUARfkEwDsGCgwAhbAGgb wAXK8AhdEIEbIKyegAYXVwYOZgwM0grtwAjtgAmLBwhTNQTjsAYqAQkNTA5poBKKAHkksArIoArv 0A5pUARHgAzr4HpQYQAQwAIeQAQwcAEcAAEv0AIqwbkD0MIQUAImAAEcwAEw0AIQ0AIqoAIEsAEs cMMFuwIwIBMr0AIsMBDfhwEmwAI7LLEYoAIwAJpQoQIrYcQugAEscK0cwAJEoABEoAJXkcQmgAAb 0AIvUMUXwMYo4AIwsAIsgI8ssAIuYAIDwAIl4AFdbMM1zMfCmQBC8BjIcAzWUA3EALNj/+AJ5JCq yaAKZgAGdoAGClYMRaASVGAFKbcMcxUGb1AG5IC2UmAHUwUF2wCz90sHxzAsE4MKxMAIgAYFlDBe UvAJdKASejBeUTAOt8x4ieYFUvAFfpAMAHwEyaAMZHQUMiETtnMl/PF7YeMUWyITyvweT/M0STIR 0Ycbwxcc8vE220ERTQERPeEQGnE7u/clVHEVWgEnD1HNxAEf1tI1NDEdMDEnztEEj6ExPDMMZCBh rnCevvAO5XAIYZAFUfBvUMAK6EsOKxcGljYAXFDIzCAIEmZfKiEIYQBGy6AKxkAMcHQKp4AKA7cB e9AM4wUFr7ByuUxylNDLvSzREUgCQP8LCsWgCuuQi84RfQlAEkkSzdlyfk6RJz+9NkcxJc/xEVLz HtiCEVbhFD+IFMHxEMyHNAehe4ESE1ctg1mNPM5RHNwTJkhizTsBEfrMF2lBGt4beY/AoKbKBhJG BxUGBa2AtgPgDGUrBnlNDuPgDCuXAlAgBYLNB49WB86wDTHHYcLQCHq1AYHwCpkAeU6gCSg3AIiQ BSQ3CisnCBH4BLDgf3oQCphADsWgDNyADNnHzFH9LSeRFFHxGythg1xiLiDR1SoRKCYxEFfRJLhh O1CBNdPiEPtBPRBxAfZSEQmAG0whg9rh2suSLvsREjQBzteSJIK8DdhtI7dWDZc8AEP/oHIe92h+ 8AcKjQn7d3IdxwmmlwibAAjhEIFWkAicYAh6IAmLVwewsAmvEAoWoghhtQFokAd1IAljoBKJcAXp WwuLd+DpuwkGJwKGoAUqQd9fcAbMkAyKah7VciSyLRHLkTbMwxw3IRB58nvU0x8DkRXodxO79zSy 83xjrYTVUgBwUs5H0iRrstvOIi3d8eFfQi901DsMkdUykdw34RXYjRoXIjNi8IGjpwgfOASdLQr7 VwqiNwBnIAt54ORPEAuEsH+D138qkQelAIiggAyr8EVckgewMHAqIQKEYA7m0IDpCwi8EAtuPgAa cAa14H+j0AzLsAwVoYQyaDQ2iHta/8IlwI0kb2MTD/Hb0kEk6DcV+1I0uNEUysN7vvd8uicd8IEe V+E9HqEVuwE1+PIl2UIQGMB86Pd96YwTRcEkD4Dk2B0XIWoJ46ALkaBvk6AJzaAJfwAIsYCInAAL sxCUPwkL1CAL7AkNhpAHgOCev8AJh6AHeYAIpQgNSCmKsoAJ40DA2aBBxTAOmrALmyCUszAHiVCU flgL0qAHhkCHlRAL0wALczAI7kkLnBANzPAKoCCC5bGD/7LaDFAAiNkuMREUik4fy5EbUrN8LLEt PREUCWABDuAAWtEQ17IcMLEVA8AmQ9PTxQMUwrceCaGEHEFHst0Qlu48v+3aRkLrSf++DeuwDM5A Cg6qiZo6qkFZiLswC9KwC7GQ7PXulboAC3UYDZAtCbwgDaW4ivD5ipMQCuVwDI/SQcZADrsgCrpA Crow7JtQCvZnDrQQ9pDKh5wgh8e+h7uwlpcwDqtQKsYBJ+hxPS0RfNnHABxR8GHiLvJSHW/zzUXR JO2yEENhEDqIHszR0+aBLc2hzuuyHxshFFpREMqzLCfREhJhFLKNEh/OEfmSEF5RI5wzP9vwCs0g CpwwCrpACQTaC+EgC4XIC5MQDrHACdBQCrzQioMIDeYuoa5ICpoQDZxQCrO/CV6vlNHgCspQRtaA CqowDr/OC9GggGupC+JAC6OYC9X/vwnmfg4KqAkZ2vbpmQmKGiROwRsnkX5OsRCHbj0qcSU0ntu/ J/lbQSReiCRX8jVsAxAHBhxAcECBgQEDCBQYYADBgAQKFDwgmABDhgcYMDzIgABDggMICxQwYIDA hQMFMCrAgAABQoIpC6B8MDFBhibXhIETAC4YuFOoin16FSqUpmi2lL7S9GvWLE7RNHGSNerVq2ic Qm2StCnTJVeafJUTNUpWVUyXXoEaFc5VumLWTmFT9clWtGbR2JYD9WrTKF6yfmGipIttNEzNNOHK pAnT46/KkhEr1lDiA4YQEWQeUKAgSgIJCRwgQADBg4IDHw7IgDCBAYsMEyRw2fLA/4XZCQjMHjgT YoLOngvstqiASIUfBWlL+JHjBxGJKWnkEPjCB5MAzU9IxGDgQAaIHXFLpJ05iABgAtQDAwdOWNBj yMZ9Gtdp1bFxl0Bl8kXKlzNRNgmFmWZeSYYVUELRhZJQVkHGFWZ62SQaV5AxcJVt8lKmGGKyEcqY YsYhZxxQklFmlVZeocQbTUYR5RVmbPFEmXKQScYTVlixhahxWjmmmGJUESahiDDLYKHMVuuMNNE6 gIEDAy44AQbdSBqAgxcg4AACCGD4IKEBMJBIAQdwewC4C1qaaaaOMGuAAQYQyKAj2FwIIACENsIh uwAWQOGChHD4YYAJ7lxgAUOhk/9IvJoaRQnMhXLCZi4PtSnGkmOOWYWcVloZERkHD7mjHGWW8SaT ZpoJRRlkOCym1VUIVOYdZpjhZpVi7kPGGGKMaWWZdUBkh71h0iHmGGOQSUW+ZbvphplQQFGmlVbJ cWVZOxzp1ddVjAFxlXWOQYgAMZmMkgADWusoISYzyCEACK7ErrQBIPAhACUmEFQJRHsoYQAEEmi0 gAMwCCkDkIBj7aUHxgUzuAzsDMCzCx5Igs8AgOAg0B9kuPPjj5kYc+SbSirJJZcOaMIaYarxiSc4 BjDCCD9OGQYVnIfJhpgyiihG02TWceWdd8TY4AgS1pjr5m3WUSQMZE6xWZtsjBn/phhsrnnjDWxo zgYcY7K5BplMUdkmnW1OyXSbV5RhtZhTslkFlXQGaOOYEblRpm1luGllHYMb4uglhQhqaLXVCojh zhcQuDcAlGoIwN+BDGAIAR765CCBC8gLGDaBEQiN3QwYmC1dgEdDzQCJA97t4goQDWAJDwbYNwAf ltAdCBd6v+yjglzqKKTREzovPfTUixmcaoRRpIwyFBEmjTjSKGOKRsqw5vmbVwlDim3u2OAUSqCX nosBtHdjjDSEMSWOMcqIgwQp7hhDEUueL8ORQspAo4xCYGMVwnBEGMTwhmSYYQ3+S4cf2DeAN7ht WulgBdbYcQprFAwmCgAPwpQE/yaXEGADC1gCvGbABCAEAAE0wJ1oWgOwDCighDVwCckiooDXgEc0 wInIQ3bDLtO07iQE2NMPOnanJXBAUHcS1A8qUIExqWkhuNlM8R42gOOtR3kym4If/FAGLnRAGEa4 gh/MMIVTTEENZeiCKUwBjp61whV2w0IZ1LABR5RhAHHwwwjcUEfxsaEPhUjBFgoxgDswYgNrjMIb BrAGLmQBG6gYRiHQEIYBBEIKVGDDAPYgBTGkAYLbUIXYTiEMYVhjktoYSHcG0DmXEAwhAEtIRwig BB3saQYLeMEPAjDCBXDANAlZjQEUsKckXG42NfnIkQQSMIaAx5i0EchoFJIAGP/c6SGbKeKg3oWv JQYAB098YnkeRrgrpvM8yUtezIKSiiNAbwDDiOcwynAEVKAhCylQxDBYdj1i2EEDj9jAFspAhkLY YQDHKMMIoJcGMqSgGKjIRhHAkIwBuEEQAzCG+BTaju9pAxnaKAMnB8AGKIChGwOgAwSRkVFNWQJI 2bDGNazhMmK6MiKzTMhwQhMaGyyhAxdbQBIG4EsbBGACw3lIBoajkAeUEAcPKwBtEnIB1NGLNRcg wAMu8FQ5EcCp2QzABy6QgQPsSQlKSEjm+vQDRPEACEDQnQxwMNV05vVh60QeMIARsyMUQRBbSEEW BlCMIoyhGGMogirGQYIioIj/GPY8Wgje0IsxDEEKWUhGIUIQBUYUQQpSWENoh1CEVIhBBHq0Qyu+ kIIUmKGlrRiDFJbBDW6YgQRbGEAdnAAGZkBQt1vYwBvIkYxjEMMaplDPekBIEYhwBFDfCU8CVBAA FSBgT0sgjS99WQO0PsQkc0JAUhdgggEwICHeEY1Xr2qSV1qAAbAUCHiqmgEQ3KkGB0jJD5ZgRJkU Kjs7ABnIeqBXMHEGTEFAHjhYpkptqAIZn2iFJzyxihyxAsM5EgQJ7GAjXhGDMp34RCZCURZKgIIc 5AgFMpZRI0wsYxXjAJU3ejGKUKToFZ1qRjLIQQlmeMMZqYoxgfCSYlD05bie/xiHhVVBjGtUo7no OSdqXjkRzoSGA7q7wRJ5cFfs+LIFnYlSCe46Aez44F/vVUjiRme5Do7EIGdd0ktOQ+AF5AAHPQhA DIyoGwRc4F4V+EAJC6yEjSF4IFckQBMoYwkbbWMb3OgGKJwxCv9EIxPLeIcrxvFpT5jBDOOwBaiA BKRV7KgVl4gGpl+Uor5cRRO2KEcoltGKXpBiFNEoxzKs4opLk6IXlq51M0DRDG+oKhRpoc8nKOwp W6xislJuLjCuaJAEqGQiThWvDpaQBBx8U184CHMAIhCagsRgB9gJwAwUEGjv0MuahPscmLItugdA 9yaykYgEemBEH7DgADvIwf9NxPQBH+QgITLowVp7IANFpzNgAhPCNiyBCmwMI2vZEKkrjO2M/mDa P8Muhyvoo5RC9AFIqVgFkz/xiDe0IhQhHwVfKFEUW7jiEqFwRVnCkYlW6KIZruhFL1BFiWiIwhl4 eQU5kOEJW3TKU87u1C3sIu0os1MA6TTARgiykYsQIALBNA2fAwADhfgycwofJmsSYGgiAApMaBXN Nr+63pvkFIcUm/gJmLADG6DZBz2ggA9+oIDC90AFE9DBAiaghCX0QF9L0AET1pxXlQiMJbRpgpTT 8/mYlcEYUSADkzvlir2FIlWKKRA5xhCFYqSiD0XYAP0caYtPe9xFojBKL5T/AQpga0IUZRl+L44y il4449KjGPIh0JAKNHSh5Z9uMjKQgXsZdQsVy9X6Dh8FERwGLN8fWEAMQnPCd7VgIb60UzCxSi8D bLlPRCANSXTTdcul95zbNEBNxmQR/wMBJqgAF+CBBaAACpArJjCBH8AlDmAC7Hi8BWCCGtgzJbA8 zOscltiMBdMi9PirAcCC0BqDVSiEMRgDRhCEMVAFE1QFOwCDMnAGMJCCVBCxVEisVVAoMxCDQshB MBgDZ1DBMRCEOgADMJAEQQADOTgDSQhCI5QEZgCDQ3CgQjiCEUiDO0ADVWAEMiADQVifNdAUVTCG VECFUwqG7lsYsbq7dDkT/9yogB2YiBNYAAjYEwgoCF9yAF/qgWiyuxJAFCDoANZYl9FYje/4jpdA CI8YGUZUABRIAkiMRHC7K0qsREu0xHQ6gARwgJJRpyn7wJhpg55BwQ1YA8ZSpELogjLogxG4gywI AzCAgrchhsRywQFIgy3IAkHwoywgg5aaA0koQiewgjq4xVhUBg1YAzJALUS6gwFgBC5IgT7oGcTa Ao0aADRQuRokBjPcCTREnq37oR0yxIwIKg/YCCBIggS4GBYoCV9SAA0ooQngAMJBlwJQAUShHQUb JstJF9MYjRuaiIxYJo2QCCSAgQhogQ3IEi1RAQ5QAYdUAQgogYfkEoiMgf8SyMgEQ5iP4ClP/EQB iJlhwIIUGMIBWAU32IBU4IIy0IDnGYETRAPGGodlWAZyqEWFYgUyiIIxCIGYdMZjUIRS9AIo6KRi SMk+SB/oIYZmHIBUuCdiYCxjKMVUMAY6kIIuEDFKOqX28MCtg4iH2Y2H4AAWSCocUIF1XIKIuBgX UAAXwI4IIIIPKJQ8iwEVAJiHkIA78YEIYIHS4JzQeKGZGI+J0IjcOEzOaYEY6AEOACccyBclgAAl 6AEd0IEYiIEJoEzMXAII0AE948gzcaqIy6L1AEFUwIMBCINxeK0U0MJCKAAuKIbQKoIiMMUoWAUH aYWUagVHGofvUYQooM3/NXCDw2KEFIgCKYgC4twCnzSGLkiBxCqGfUKfYliDEOiC11sFNIAsNIiC IfiCXUEFmzIFNATJq1KwqjKAGFgrJ5KAEviBE9gICagAIogAcqoAJJgIE0gCI7IB0/COBECCBvwB HdiMzFCJmRCTyziTmyiIp3oYDpABGYgBGZBIGdCBCqwBu6qBysxQu6KBGZCACIgACZgNDow449E6 vzKFayCGTrAFTmmFT0CGHFmFTjgGVVAF+8gRqKPRbkmWZWiGTOiLdyA1GtUwDcPNHO0EhbI+HKlR 3MRN+8DNp5sPpQCVTrAPCFmGbTgG8URDnpgydvmggcg2MDmAMxENrTIN/84RvyiKCNoQmEaZjdJI l0DTvDOJJa1C0Sui0BIIgBJQgkCNAQgAVCOSgI+4AHTi071SUWAwhWFwUQpbC5PDvafLME94uh1x NltgBVUAElXwhFfAhBbRBGYwufmgsafDME/wAzHQuUuQ0ZMzUgu7Pme7BZNzNgvL1AxDhnRwEFex FCC5BjCROxBKE6r6CARbiIVwCE3UiHxrRJbwv82rIkaNOIkkVByIARxoAQk4ARuwgQhYgRVQsGtt VJCshlM4lh3BBFHIVVXNVOu7Phi1C1AhQ1SzVVcYVVcgh0/w11LDkeuTo6t4hVh1NupTCupzNgpj 2EzlVVbohIk6hTcKhv9qqAZrkAtirSVjHcR3C0tlfZiUAJ3ZQCv+spzhAFDOyQ06sSIkuVaBUFN0 IQjcsIg2ZZJzHU1wbC5TUKVcYQWok9cMi9JevdRu4UZUIIZUUAUMo9GgvT4cwTAq7RFYldEmq9Uc mVcZ6VHrq9EaVYVUwAbu+0B2SjDoIqab0I2HMaaYDUtIIQmCSBk5mZPh4S/+Qhk5KQiPXNuUQJkM qNncOCu8NQkrylkUZTCvZB5rQIVUKAZjGEPHPbWVa9yqhNyJGgapCYqkPbXHzdEcjb3Yq8qmtdSI HUNvOV1vMV18BZFUaNzY40au/LzPU48qi1mPCLS2JRIMQNHcFQ24paZXmAiJkihcrjOJkiAJwiVe w11eLAKGb/iGZ3jeb1APcDCFzB0G7MVem8nc683eU3KZ9mie95CajMte75Wam1HalUNa7zVfzNVe 7bUZzJUabxSA6JVe6Q0IADs= ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://clincancerres.aacrjournals.org/icons/spacer.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAQAICRAEAOw== ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://clincancerres.aacrjournals.org/icons/shared/misc/arrowTtrim.gif R0lGODlhBAAJAIABAGZmZv///yH5BAEAAAEALAAAAAAEAAkAAAIKjAMHidsLm2HHFAA7 ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://clincancerres.aacrjournals.org/math/large/gamma.gif R0lGODlhCgAPAOMAAAAAAHt5e2tta1pdWlJRUkJFQr2+vaWipf///zk4OSksKSEkIRgYGBAQEAgI CAAAACH5BAEAAAgALAAAAAAKAA8AAAQ+ECWwkB1AHNdAsFNQEJJiAQwSGIjRHFhhzU2gOMd8BYys I4MO6xcA+H4uwe/iWSIUgIHTEZ1Wl4uG0zK0RAAAOw== ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://clincancerres.aacrjournals.org/math/large/delta.gif R0lGODlhCAAOAOMAAAAAAG1tbVFRUUVFRS0tLaKioo6Ojv///xgYGBAQEAAAAAAAAAAAAAAAAAAA AAAAACH5BAEAAAcALAAAAAAIAA4AAAQz8JyAABjSCMkPIZ0UAGA4llxRoQdSnNJgSAQgFElKCuz3 dQQeoCDBHQykAi4gEVgQs0MEADs= ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://clincancerres.aacrjournals.org/math/gamma.gif R0lGODlhCQALAOMAAAAAAJ2dnYmJiU1NTRkZGWhoaP///0JCQiwsLAAAAAAAAAAAAAAAAAAAAAAA AAAAACH5BAEAAAYALAAAAAAJAAsAAAQf0AQCjpEinFKQMAV4XYM4Xtw5pir4tWVrIPIss+p7RQA7 ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://clincancerres.aacrjournals.org/math/delta.gif R0lGODlhBgALAMIAAAAAACQkJElJSW1tbZKSkra2ttvb2////yH5BAEAAAcALAAAAAAGAAsAQAMg eBpjQKcMFUGhjYI4z7DUQRhCRwQUMaxHABWCNwXGkQAAOw== ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://clincancerres.aacrjournals.org/javascript/ajax/xmlhttprequest.js /*=0A= =0A= Cross-Browser XMLHttpRequest v1.2=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Emulate Gecko 'XMLHttpRequest()' functionality in IE and Opera. Opera = requires=0A= the Sun Java Runtime Environment .=0A= =0A= by Andrew Gregory=0A= http://www.scss.com.au/family/andrew/webdesign/xmlhttprequest/=0A= =0A= This work is licensed under the Creative Commons Attribution License. To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://clincancerres.aacrjournals.org/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= }=0A= else if (name =3D=3D "border-color") {=0A= e.style.borderColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left") {=0A= e.style.borderLeft =3D value;=0A= }=0A= else if (name =3D=3D "border-left-color") {=0A= e.style.borderLeftColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left-style") {=0A= e.style.borderLeftStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-left-width") {=0A= e.style.borderLeftWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-right") {=0A= e.style.borderRight =3D value;=0A= }=0A= else if (name =3D=3D "border-right-color") {=0A= e.style.borderRightColor =3D value;=0A= }=0A= else if (name =3D=3D "border-right-style") {=0A= e.style.borderRightStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-right-width") {=0A= e.style.borderRightWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-style") {=0A= e.style.borderStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top") {=0A= e.style.borderTop =3D value;=0A= }=0A= else if (name =3D=3D "border-top-color") {=0A= e.style.borderTopColor =3D value;=0A= }=0A= else if (name =3D=3D "border-top-style") {=0A= e.style.borderTopStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top-width") {=0A= e.style.borderTopWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-width") {=0A= e.style.borderWidth =3D value;=0A= }=0A= else if (name =3D=3D "bottom") {=0A= e.style.bottom =3D value;=0A= }=0A= else if (name =3D=3D "clear") {=0A= e.style.clear =3D value;=0A= }=0A= else if (name =3D=3D "clip") {=0A= e.style.clip =3D value;=0A= }=0A= else if (name =3D=3D "color") {=0A= e.style.color =3D value;=0A= }=0A= else if (name =3D=3D "cssText") {=0A= e.style.Sets =3D value;=0A= }=0A= else if (name =3D=3D "cursor") {=0A= e.style.cursor =3D value;=0A= }=0A= else if (name =3D=3D "direction") {=0A= e.style.direction =3D value;=0A= }=0A= else if (name =3D=3D "display") {=0A= e.style.display =3D value;=0A= }=0A= else if (name =3D=3D "font") {=0A= e.style.font =3D value;=0A= }=0A= else if (name =3D=3D "font-family") {=0A= e.style.fontFamily =3D value;=0A= }=0A= else if (name =3D=3D "font-size") {=0A= e.style.fontSize =3D value;=0A= }=0A= else if (name =3D=3D "font-style") {=0A= e.style.fontStyle =3D value;=0A= }=0A= else if (name =3D=3D "font-variant") {=0A= e.style.fontVariant =3D value;=0A= }=0A= else if (name =3D=3D "font-weight") {=0A= e.style.fontWeight =3D value;=0A= }=0A= else if (name =3D=3D "height") {=0A= e.style.height =3D value;=0A= }=0A= else if (name =3D=3D "ime-mode") {=0A= e.style.imeMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-flow") {=0A= e.style.layoutFlow =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid") {=0A= e.style.layoutGrid =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-char") {=0A= e.style.layoutGridChar =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-line") {=0A= e.style.layoutGridLine =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-mode") {=0A= e.style.layoutGridMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-type") {=0A= e.style.layoutGridType =3D value;=0A= }=0A= else if (name =3D=3D "left") {=0A= e.style.left =3D value;=0A= }=0A= else if (name =3D=3D "letter-spacing") {=0A= e.style.letterSpacing =3D value;=0A= }=0A= else if (name =3D=3D "line-break") {=0A= e.style.lineBreak =3D value;=0A= }=0A= else if (name =3D=3D "line-height") {=0A= e.style.lineHeight =3D value;=0A= }=0A= else if (name =3D=3D "list-style") {=0A= e.style.listStyle =3D value;=0A= }=0A= else if (name =3D=3D "list-style-image") {=0A= e.style.listStyleImage =3D value;=0A= }=0A= else if (name =3D=3D "list-style-position") {=0A= e.style.listStylePosition =3D value;=0A= }=0A= else if (name =3D=3D "list-style-type") {=0A= e.style.listStyleType =3D value;=0A= }=0A= else if (name =3D=3D "margin") {=0A= e.style.margin =3D value;=0A= }=0A= else if (name =3D=3D "margin-bottom") {=0A= e.style.marginBottom =3D value;=0A= }=0A= else if (name =3D=3D "margin-left") {=0A= e.style.marginLeft =3D value;=0A= }=0A= else if (name =3D=3D "margin-right") {=0A= e.style.marginRight =3D value;=0A= }=0A= else if (name =3D=3D "margin-top") {=0A= e.style.marginTop =3D value;=0A= }=0A= else if (name =3D=3D "min-height") {=0A= e.style.minHeight =3D value;=0A= }=0A= else if (name =3D=3D "overflow") {=0A= e.style.overflow =3D value;=0A= }=0A= else if (name =3D=3D "overflow-x") {=0A= e.style.overflowX =3D value;=0A= }=0A= else if (name =3D=3D "overflow-y") {=0A= e.style.overflowY =3D value;=0A= }=0A= else if (name =3D=3D "padding") {=0A= e.style.padding =3D value;=0A= }=0A= else if (name =3D=3D "padding-bottom") {=0A= e.style.paddingBottom =3D value;=0A= }=0A= else if (name =3D=3D "padding-left") {=0A= e.style.paddingLeft =3D value;=0A= }=0A= else if (name =3D=3D "padding-right") {=0A= e.style.paddingRight =3D value;=0A= }=0A= else if (name =3D=3D "padding-top") {=0A= e.style.paddingTop =3D value;=0A= }=0A= else if (name =3D=3D "page-break-after") {=0A= e.style.pageBreakAfter =3D value;=0A= }=0A= else if (name =3D=3D "page-break-before") {=0A= e.style.pageBreakBefore =3D value;=0A= }=0A= else if (name =3D=3D "pixelBottom") {=0A= e.style.pixelBottom =3D value;=0A= }=0A= else if (name =3D=3D "pixelHeight") {=0A= e.style.pixelHeight =3D value;=0A= }=0A= else if (name =3D=3D "pixelLeft") {=0A= e.style.pixelLeft =3D value;=0A= }=0A= else if (name =3D=3D "pixelRight") {=0A= e.style.pixelRight =3D value;=0A= }=0A= else if (name =3D=3D "pixelTop") {=0A= e.style.pixelTop =3D value;=0A= }=0A= else if (name =3D=3D "pixelWidth") {=0A= e.style.pixelWidth =3D value;=0A= }=0A= else if (name =3D=3D "posBottom") {=0A= e.style.posBottom =3D value;=0A= }=0A= else if (name =3D=3D "posHeight") {=0A= e.style.posHeight =3D value;=0A= }=0A= else if (name =3D=3D "position") {=0A= e.style.position =3D value;=0A= }=0A= else if (name =3D=3D "posLeft") {=0A= e.style.posLeft =3D value;=0A= }=0A= else if (name =3D=3D "posRight") {=0A= e.style.posRight =3D value;=0A= }=0A= else if (name =3D=3D "posTop") {=0A= e.style.posTop =3D value;=0A= }=0A= else if (name =3D=3D "posWidth") {=0A= e.style.posWidth =3D value;=0A= }=0A= else if (name =3D=3D "right") {=0A= e.style.right =3D value;=0A= }=0A= else if (name =3D=3D "ruby-align") {=0A= e.style.rubyAlign =3D value;=0A= }=0A= else if (name =3D=3D "ruby-overhang") {=0A= e.style.rubyOverhang =3D value;=0A= }=0A= else if (name =3D=3D "ruby-position") {=0A= e.style.rubyPosition =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-3dlight-color") {=0A= e.style.scrollbar3dLightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-arrow-color") {=0A= e.style.scrollbarArrowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-base-color") {=0A= e.style.scrollbarBaseColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-darkshadow-color") {=0A= e.style.scrollbarDarkShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-face-color") {=0A= e.style.scrollbarFaceColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-highlight-color") {=0A= e.style.scrollbarHighlightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-shadow-color") {=0A= e.style.scrollbarShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-track-color") {=0A= e.style.scrollbarTrackColor =3D value;=0A= }=0A= else if (name =3D=3D "float") {=0A= e.style.styleFloat =3D value;=0A= }=0A= else if (name =3D=3D "table-layout") {=0A= e.style.tableLayout =3D value;=0A= }=0A= else if (name =3D=3D "text-align") {=0A= e.style.textAlign =3D value;=0A= }=0A= else if (name =3D=3D "text-align-last") {=0A= e.style.textAlignLast =3D value;=0A= }=0A= else if (name =3D=3D "text-autospace") {=0A= e.style.textAutospace =3D value;=0A= }=0A= else if (name =3D=3D "text-decoration") {=0A= e.style.textDecoration =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationBlink") {=0A= e.style.textDecorationBlink =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationLineThrough") {=0A= e.style.textDecorationLineThrough =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationNone") {=0A= e.style.textDecorationNone =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationOverline") {=0A= e.style.textDecorationOverline =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationUnderline") {=0A= e.style.textDecorationUnderline =3D value;=0A= }=0A= else if (name =3D=3D "text-indent") {=0A= e.style.textIndent =3D value;=0A= }=0A= else if (name =3D=3D "text-justify") {=0A= e.style.textJustify =3D value;=0A= }=0A= else if (name =3D=3D "text-kashida-space") {=0A= e.style.textKashidaSpace =3D value;=0A= }=0A= else if (name =3D=3D "text-overflow") {=0A= e.style.textOverflow =3D value;=0A= }=0A= else if (name =3D=3D "text-transform") {=0A= e.style.textTransform =3D value;=0A= }=0A= else if (name =3D=3D "text-underline-position") {=0A= e.style.textUnderlinePosition =3D value;=0A= }=0A= else if (name =3D=3D "top") {=0A= e.style.top =3D value;=0A= }=0A= else if (name =3D=3D "unicode-bidi") {=0A= e.style.unicodeBidi =3D value;=0A= }=0A= else if (name =3D=3D "vertical-align") {=0A= e.style.verticalAlign =3D value;=0A= }=0A= else if (name =3D=3D "visibility") {=0A= e.style.visibility =3D value;=0A= }=0A= else if (name =3D=3D "white-space") {=0A= e.style.whiteSpace =3D value;=0A= }=0A= else if (name =3D=3D "width") {=0A= e.style.width =3D value;=0A= }=0A= else if (name =3D=3D "word-break") {=0A= e.style.wordBreak =3D value;=0A= }=0A= else if (name =3D=3D "word-spacing") {=0A= e.style.wordSpacing =3D value;=0A= }=0A= else if (name =3D=3D "word-wrap") {=0A= e.style.wordWrap =3D value;=0A= }=0A= else if (name =3D=3D "writing-mode") {=0A= e.style.writingMode =3D value;=0A= }=0A= else if (name =3D=3D "z-index") {=0A= e.style.zIndex =3D value;=0A= }=0A= else if (name =3D=3D "zoom") {=0A= e.style.zoom =3D value;=0A= }=0A= }=0A= catch (e) {=0A= /* ignore error on attempt to set e.style.[property] */=0A= }=0A= }=0A= }=0A= }=0A= ------=_NextPart_000_0000_01C678EB.B322AE40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://clincancerres.aacrjournals.org/javascript/entrez/callback.js /************************************************************************= *****=0A= * javascript/entrez/callback.js=0A= *=0A= * Entrez Linking callback to populate content box.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Execute callback to fill content box with Entrez Linking information.=0A= */=0A= function entrez_callback(pmid, callback_url) {=0A= /*=0A= * MSIE 5.5 and below have issues with the JavaScript=0A= * used for Entrez Linking. For now we have to disable=0A= * the callback until we can track down a proper fix=0A= * (or everybody sanely upgrades to version 6 or 7!).=0A= */=0A= if (navigator) {=0A= var appname =3D navigator.appName;=0A= if (appname =3D=3D "Microsoft Internet Explorer") {=0A= var userAgent =3D navigator["userAgent"];=0A= var s =3D "MSIE ";=0A= var n =3D -1; =0A= if ((n =3D userAgent.indexOf(s)) !=3D -1) {=0A= var v =3D parseFloat(userAgent.substring(n+s.length));=0A= if (v < 6) {=0A= return;=0A= }=0A= }=0A= }=0A= }=0A= =0A= /*=0A= * Acquire table row element to update, initiate callback=0A= * to update table with Entrez Links.=0A= */=0A= var tr =3D document.getElementById('entrez_callback_'+pmid);=0A= if (!tr) {=0A= return;=0A= }=0A= var req =3D new XMLHttpRequest();=0A= if (!req) {=0A= return;=0A= }=0A= req.onreadystatechange =3D function() {=0A= if (req.readyState =3D=3D 4 && (req.status =3D=3D 200 || req.status = =3D=3D 304)) {=0A= var src =3D req.responseXML.documentElement;=0A= var dst =3D document.createDocumentFragment();=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], dst);=0A= }=0A= var tbl =3D tr.parentNode;=0A= tbl.replaceChild(dst, tr);=0A= }=0A= }=0A= req.open('GET', callback_url, true);=0A= req.send(null);=0A= }=0A= ------=_NextPart_000_0000_01C678EB.B322AE40--