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Gamma knife surgery for multiple
hemangioblastomas
Park YS, Chang JH, Chang JW, Chung SS, Park YG
Department of Neurosurgery, Yonsei University College of Medicine, Seoul,
Korea.
Object. The authors describe their experience in treating patients with
hemangioblastoma, especially multiple lesions, with gamma knife surgery
(GKS).
Methods. Nine patients with 84 hemangioblastomas underwent GKS
between July 1992 and May 2003.
Three patients harbored a single lesion and
six patients had multiple lesions.
Of the six patients with multifocal
tumors, a diagnosis of von Hippel-Lindau disease had been established in
five.
In the patients with multiple lesions, the mean radiation dose
delivered to the tumor margin was 16.6 Gy (range 12.8-29.75 Gy).
The mean
margin isodose was 60% (range 40-95%).
Three of the 84 lesions failed to be
controlled after a mean follow-up period of 4.3 years (range 8.6-141
months).
One patient who had undergone two GKS treatments suffered delayed
radiation-induced complications, and posterior fossa decompression and
ventriculoperitoneal shunt insertion were required.
Conclusions. To achieve
tumor control and avoid morbidity, the surgeon should keep in mind
minimizing field overlapping by using a small-diameter collimator or
applying a steep dose gradient, and by accurate dose prescription.
PMID: 15662788 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15662788
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