From: Subject: Cancer Cell -- Taylor et al. Date: Mon, 21 Jul 2008 15:38:55 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_00BE_01C8EB47.E26367F0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_00BE_01C8EB47.E26367F0 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.cancercell.org/content/article/abstract?uid=PIIS1535610805002709 =EF=BB=BF Cancer Cell -- Taylor et = al. =

Copyright =C2=A9 2005 Cell Press. All rights=20 reserved.
Cancer Cell, Vol 8, 323-335, October 2005

Article

Radial = glia cells=20 are candidate stem cells of ependymoma

Michael D. Taylor,1,8 = Helen Poppleton,1,8 = Christine Fuller,2 Xiaoping Su,3 Yongxing Liu,3 = Patricia Jensen,1 = Susan Magdaleno,1 James Dalton,2 = Christopher Calabrese,1 Julian Board,1 = Tobey MacDonald,4 Jim Rutka,5 Abhijit Guha,6 Amar Gajjar,7 Tom Curran,1 and Richard=20 J. Gilbertson1,7,*

1 Department = of=20 Developmental Neurobiology, St. Jude Children=E2=80=99s Research = Hospital, 332 North=20 Lauderdale Street, Memphis, Tennessee 381052 Department = of=20 Pathology, St. Jude Children=E2=80=99s Research Hospital, 332 North = Lauderdale Street,=20 Memphis, Tennessee 381053 Hartwell = Center for=20 Bioinformatics and Biotechnology, St. Jude Children=E2=80=99s Research = Hospital, 332=20 North Lauderdale Street, Memphis, Tennessee 381054 Department = of=20 Pediatric Hematology and Oncology, Children=E2=80=99s National Medical = Center,=20 Washington, D.C. 200105 Division = of=20 Neurosurgery and the Arthur and Sonia Labatt Brain Tumor Research = Center,=20 Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada6 Division = of=20 Neurosurgery, Toronto Western Hospital, Toronto, Ontario M5T 2S8,=20 Canada
7 Department = of=20 Hematology/Oncology, St. Jude Children=E2=80=99s Research Hospital, = Memphis, Tennessee=20 38105
8 These = authors=20 contributed equally to this work.

*Corresponding author
Richard J.=20 Gilbertson
Ph: 901 495 3913
Fax: 901 495 2270
richard.gilbertson@stjude.o= rg


Summary


Tumors of the same histologic = type often=20 comprise clinically and molecularly distinct subgroups; however, the = etiology of=20 these subgroups is unknown. Here, we report that histologically = identical, but=20 genetically distinct, ependymomas exhibit patterns of gene expression = that=20 recapitulate those of radial glia cells in the corresponding region of = the=20 central nervous system. Cancer stem cells isolated from ependymomas = displayed a=20 radial glia phenotype and formed tumors when orthotopically transplanted = in=20 mice. These findings identify restricted populations of radial glia = cells as=20 candidate stem cells of the different subgroups of ependymoma, and they = support=20 a general hypothesis that subgroups of the same histologic tumor type = are=20 generated by different populations of progenitor cells in the tissues of = origin.

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PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } .cover_image_table_top_right { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 0px; BORDER-LEFT: 0px; WIDTH: 634px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } .cover_image_table_bottom_right { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 0px; BORDER-LEFT: 0px; WIDTH: 634px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } .general_table_top { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 20px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 10px; BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } .general_table_bottom { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 10px; BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } TD.cover_image { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: top; WIDTH: 96px; PADDING-TOP: 0px; TEXT-ALIGN: center } TD.descriptive_content { BORDER-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: 4px; VERTICAL-ALIGN: = top; BORDER-LEFT: 0px; WIDTH: 730px; BORDER-BOTTOM: 0px } TD.cover_image_content { BORDER-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: 4px; VERTICAL-ALIGN: = top; BORDER-LEFT: 0px; WIDTH: 414px; BORDER-BOTTOM: 0px } TD.cover_image_content_footer { BORDER-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: 4px; VERTICAL-ALIGN: = top; BORDER-LEFT: 0px; WIDTH: 634px; BORDER-BOTTOM: 0px } .cover_image_title { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333333; FONT-FAMILY: = Arial,Helvetica,sans_serif } TD.browse_archive { PADDING-LEFT: 4px; VERTICAL-ALIGN: 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