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Invasive meningioma is associated with a low expression
of E-cadherin and beta-catenin
Utsuki S, Oka H, Sato Y, Kawano N, Tsuchiya B, Kobayashi I, Fujii K
Department of Neurosurgery, Kitasato University School of Medicine,
Sagamihara, Kanagawa, Japan. utsuki@med.kitasato-u.ac.jp
Invasive meningioma shows benign histological features (WHO grade 1) and the
brain expansion at the tumor-brain interface, and recurs more frequently
than common meningiomas.
To determine the mechanism of brain expansion, we
studied the relationship between invasive meningioma and cell adhesion
molecules.
Immunostaining for E-cadherin (E-CH), N-cadherin (N-CH),
beta-catenin, and Ki-67 was performed in 103 meningiomas that consisted of
61 meningothelial meningiomas, 25 fibrous meningiomas, 12 invasive
meningiomas and 5 anaplastic meningiomas.
All tumors were negative for N-CH.
All the 61 meningothelial meningiomas, 10 of 12 invasive meningiomas, and 3
of 5 anaplastic meningiomas were positive for both E-CH and beta-catenin,
while these were both negative in all of the fibrous meningiomas.
In
invasive meningiomas, the expansive part of the tumor showed a lower rate
(4/12 tumors) of E-CH and beta-catenin positivity, while the central part
showed a higher rate (10/12 tumors).
The Ki-67 labeling index was higher in
invasive and anaplastic meningiomas than in meningothelial meningiomas.
These results suggest that a reduction in cell adhesion molecules and
increased proliferative activity may be related, which may lead to a better
understanding of the mechanism of meningioma expansion in the future.
PMID: 15696778 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15696778
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