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Cerebral edema associated with Gliadel wafers: Two case studies Emil L. Weber and Eric A. Goebel
Tri-State Neurosurgical, Inc., Evansville, IN 47710,
USA. Address correspondence to Eric
Goebel, Tri-State Neurosurgical,Inc., 350 West Columbia Street, Suite
350, Evansville, IN 47710, USA (egoebel@iupui.edu).
While the introduction of carmustine wafers (Gliadel wafers) into
the tumor resection cavity has been shown to be a beneficial therapy
for malignant glioma, it is recognized that clinically significant
cerebral edema is a potential adverse effect.
Following are two
clinical case reports demonstrating profound cerebral edema associated
with implantation of Gliadel wafers.
As a result, one of these
individuals had premature death.
A brief literature review is provided
to assist in explaining the mechanisms by which clinically significant
cerebral edema may develop.
© 2005 Duke University Press
Source: http://hermia.ingentaselect.com/cgi-bin/linker?ini=dup_no&reqidx=/cw/dup/15228517/v7n1/s9/p84&user_id=undefined
DOI: http://dx.doi.org/10.1215/S1152851704000614
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