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Treatment outcomes and prognostic factors in patients with
supratentorial low-grade gliomas
S-A Yeh, MD, J-T
Ho, MD, C-C Lui, MD, Y-J Huang, MD, C-Y
Hsiung, MD and E-Y Huang, MD
Department of Radiation Oncology
[S.-A.Y, Y.-J.H., C.-Y.H., E.-Y.H], Neurosurgery [J.-T.H.] and
Radiology [C.-C.L.], Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Correspondence: Dr Shyh-An Yeh, 5F., No.181, Wen-Chuan Road, Zuoying
District, Kaohsiung City 81361, Taiwan (R.O.C.)
Low-grade gliomas account for 10–15%
of all adult primary intracranial tumours.
Currently, there is no consensus on the treatment strategy
for low-grade gliomas.
This study was designed to evaluate the treatment outcomes,
prognostic factors and radiation-related late
complications, as well as to assess whether or not post-operative
radiotherapy has benefit on local control and overall survival
in this population.
We retrospectively reviewed 93 consecutive adult patients
with supratentorial low-grade gliomas diagnosed at our
institution from July 1985 to December 1997.
All patients underwent surgical intervention and 60 of them
received post-operative radiotherapy.
With a median follow-up of 110 months for surviving patients,
the 5-year overall and progression-free survival rates were
57% and 47%, respectively.
46 patients experienced local progression of disease during
the follow-up period.
In multivariate analysis, age at diagnosis, extent of
surgery and post-operative Karnofsky performance status
showed independent prognostic significance for
progression-free and overall survival rates.
Post-operative radiotherapy had independent prognostic
value for progression-free survival.
This analysis has changed our practice and we suggest that
aggressive surgical resection and post-operative radiotherapy might
be considered for patients with low-grade gliomas.
Further efforts should be made to optimize radiotherapy
techniques and to integrate new therapeutic modalities.
© 2005 British Institute of
Radiology
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