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The effect of cyclin D expression on cell proliferation
in human gliomas
Zhang X, Zhao M, Huang AY, Fei Z, Zhang W, Wang XL
Department of Neurosurgery, Xi-Jing Hospital, The Fourth Military Medical
University, Xi'an, China.
The expression of three cyclin D subtypes was defined immunohistochemically
with cyclin D1, D2 and D3 monoclonal antibodies in 52 human glioma biopsies
and eight control samples of normal brain tissue.
PCNA labeling indices (LI)
were used to evaluate proliferation in the glioma biopsies.
LI of cyclin D1,
D2 and D3 were compared with histological grade and the proliferating cell
nuclear antigen (PCNA) LI.
Cyclin D1 expression only was observed in normal
brain tissue, but marked overexpression of cyclin D1 and cyclin D3 was
observed in glioma.
Cyclin D1 LI increased with malignancy, in parallel with
an increase in PCNA LI.
Lower expression of cyclin D2 was found in a small
fraction of the gliomas, but its LI did not vary significantly with grade.
Cyclin D3 was mainly expressed by malignant gliomas and was rarely observed
in low-grade glioma.
Cyclin D2 and D3 expression correlated with PCNA LI,
but not as strongly as for cyclin D1.
Expression of cyclin D1 is closely
related to both the oncogenesis and progression of glioma, while cyclin D3
is associated with transformation to a malignant phenotype.
Cyclin D2 is
weakly expressed and shows no marked relationship with any aspect of
tumorigenesis.
The exact contribution of cyclin D subtypes to cell cycle
progression in neoplastic and reactive cells remains to be defined.
PMID: 15749420 [PubMed - as supplied by publisher]
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