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Second Malignant
Neoplasms Following the Treatment of Brain Tumors in Children
Münevver Büyükpamukçu,
MD; Ali Varan, MD*; Nalan Yazici, MD; Nejat Akalan, MD; Figen Söylemezoglu,
MD; Faruk Zorlu, MD; Canan Akyüz, MD; M. Tezer Kutluk, MD, PhD
Department
of Pediatric Oncology Institute of Oncology Hacettepe University [MB,
AV, NY]. Department of Neurosurgery, Faculty of Medicine, Hacettepe
University [NA]. Department of Pathology, Faculty of Medicine,
Hacettepe University [FS]. Department of Radiation Oncology, Faculty
of Medicine, Hacettepe University [FZ]. Department of Pediatric
Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey
[CA, TK]. -- *Corresponding Author: Dr Ali Varan, Department of
Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100
Ankara, Turkey. Tel: +90-312-3052990; fax: +90-312-3107018; e-mail:
hupog@tr.net.
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We investigated retrospectively 992
children with central nervous system tumors who were treated at our
center between 1970 and 2004.
All of the patients were treated by
surgery, chemotherapy, and/or radiotherapy.
Six patients developed second malignant
neoplasms, and their clinical and histopathologic characteristics are
reviewed in this article.
The second malignant neoplasms were
diagnosed as non-Hodgkin lymphoma, myelodysplastic syndrome, basal
cell carcinoma, malignant melanoma, Kaposi sarcoma, and high-grade
neuroectodermal tumor.
The initial diagnoses were
ependymoblastoma in one, medulloblastoma in three, and low-grade
astrocytoma in two patients.
The median latency time was 3.03 years
(range 0.39–22.93 years).
The outcome varied according to the
histopathologic type of the second tumor.
The patients who developed non-Hodgkin
lymphoma and myelodysplastic syndrome died of progressive
disease.
The patients with second skin neoplasms
are alive as of the time of this writing.
The patient with Kaposi sarcoma developed
one of the rare reported second malignant neoplasms following a
primary brain tumor in childhood.
A wide spectrum of second malignant
neoplasms was detected after treatment of primary brain tumors with
surgery, radiotherapy, and chemotherapy.
Long-term follow-up is therefore necessary
for the child who has survived a primary central nervous system tumor.
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