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Late response to radiochemotherapy in
pediatric glioblastoma: report on two patients treated according to
HIT-GBM protocols
C. F. Classen A1, A2,
M. Warmuth-Metz A3, K. Papke A4, A.
Trotter A1, A5, J. E. A. Wolff A6, A7,
S. Wagner A7
A1 Children's
Hospital, Wedau Kliniken, Klinikum Duisburg, Duisburg, Germany. A2 University
Children's Hospital, Rostock, Germany. A3 Department
of Neuroradiology, University of Würzburg, Würzburg, Germany. A4 Clinic
of Radiology and Neuroradiology, Wedau Kliniken, Klinikum Duisburg,
Duisburg, Germany. A5 Hegau-Klinikum GmbH, Singen,
Germany. A6 M.D. Anderson Cancer Center of the
University of Texas, Department of Pediatrics, Pediatric Neurooncology
Section, Houston, Texas, USA. A7 University of
Regensburg, Department of Pediatric Oncology, Regensburg, Germany
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High-grade gliomas in children are rare
and the best treatment is undetermined.
The German language group study HIT-GBM
compares various induction protocols for subsequent patient
cohorts.
Currently, cisplatinum, etoposide,
ifosfamide, and vincristine are given simultaneously with
extended-field radiotherapy.
Imaging is done 3 weeks after to define
treatment response, followed by 6-weekly controls during consolidation
with lomustine, vincristine, and prednisone. The authors report on 2
patients with incompletely resected glioblastoma multiforme in which
response was lacking 3 weeks after radiochemotherapy but became
evident 12 weeks later.
This suggests that later time points are
required to assess induction protocol response.
Keywords: glioblastoma, response
control, radiochemotherapy, pediatric
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