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From: Subject: Taylor & Francis Group - Article Date: Tue, 5 Dec 2006 18:31:57 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0007_01C7189B.A539BAD0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2962 This is a multi-part message in MIME format. ------=_NextPart_000_0007_01C7189B.A539BAD0 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://taylorandfrancis.metapress.com/(gwvp5n3tcftbdm55v1zta0aa)/app/home/contribution.asp?referrer=parent&backto=issue,4,10;journal,2,63;linkingpublicationresults,1:102484,1 =EF=BB=BF Taylor & Francis Group - Article

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Pediatric = Hematology=20 and Oncology

Publisher: Taylor & Francis

Issue: = Volume 23, Number 8 / December 2006 =

Pages: 631 - 637

URL: Linking=20 Options

DOI: 10.1080/08880010600951088=20

LATE RESPONSE TO RADIOCHEMOTHERAPY IN PEDIATRIC=20 GLIOBLASTOMA: Report on Two Patients Treated According = to=20 HIT-GBM Protocols

C. F. Classen ^{A1, A2}, M. Warmuth-Metz=20 ^A3, K. Papke ^A4, A. Trotter = ^{A1,=20
A5}, J. E. A. Wolff ^{A6, A7}, S. Wagner=20 ^A7

^A1 Children's Hospital, Wedau = Kliniken,=20 Klinikum Duisburg, Duisburg,=20 Germany
^A2 University Children's = Hospital,=20 Rostock, Germany
^A3 Department of=20 Neuroradiology, University of W=C3=BCrzburg, = W=C3=BCrzburg,=20 Germany
^A4 Clinic of Radiology and=20 Neuroradiology, Wedau Kliniken, Klinikum Duisburg, = Duisburg,=20 Germany
^A5 Hegau-Klinikum GmbH, = Singen,=20 Germany
^A6 M.D. Anderson Cancer = Center of=20 the University of Texas, Department of Pediatrics, = Pediatric=20 Neurooncology Section, Houston, Texas,=20 USA
^A7 University of Regensburg, = Department=20 of Pediatric Oncology, Regensburg, Germany

Abstract:

High-grade gliomas in children are rare and the = best=20 treatment is undetermined. The German language group = study=20 HIT-GBM compares various induction protocols for = subsequent=20 patient cohorts. Currently, cisplatinum, etoposide,=20 ifosfamide, and vincristine are given simultaneously = with=20 extended-field radiotherapy. Imaging is done 3 weeks = after to=20 define treatment response, followed by 6-weekly = controls=20 during consolidation with lomustine, vincristine, and=20 prednisone. The authors report on 2 patients with = incompletely=20 resected glioblastoma multiforme in which response was = lacking=20 3 weeks after radiochemotherapy but became evident 12 = weeks=20 later. This suggests that later time points are = required to=20 assess induction protocol response.

Keywords:

glioblastoma, response control, radiochemotherapy,=20 pediatric

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FONT-SIZE: 8pt; PADDING-BOTTOM: 1px; BORDER-LEFT: = #999999 0px solid; COLOR: #666666; PADDING-TOP: 2px; BORDER-BOTTOM: = #999999 0px solid; FONT-FAMILY: Arial, Helvetica, sans-serif; = BACKGROUND-COLOR: #f5f5f5; TEXT-ALIGN: center } TABLE.Block { FONT: 9pt Arial; MARGIN-LEFT: 0px; COLOR: #000000; MARGIN-RIGHT: 0px } TD { FONT: 9pt Arial; COLOR: #000000; TEXT-DECORATION: none } TD.Heading { BORDER-RIGHT: #003366 1px solid; BORDER-TOP: #003366 1px solid; = FONT-WEIGHT: bold; FONT-SIZE: 11px; BORDER-LEFT: #003366 1px solid; = WIDTH: 150px; COLOR: #ffffff; BORDER-BOTTOM: #003366 0px solid; = FONT-FAMILY: Arial, Helvetica, sans-serif } TD.Bold { FONT-WEIGHT: bold } TD.ContainerLine { BACKGROUND-COLOR: #003366 } TD.ContainerHeader { BORDER-RIGHT: #404040 1px solid; BORDER-TOP: #404040 1px solid; = FONT-WEIGHT: bold; FONT-SIZE: 9pt; BORDER-LEFT: #404040 1px solid; = COLOR: #ffffff; BORDER-BOTTOM: #404040 1px solid; FONT-FAMILY: Arial, = Helvetica, sans-serif; BACKGROUND-COLOR: #003366 } TD.ContainerBody { BORDER-RIGHT: #404040 1px solid; BORDER-TOP: #404040 0px solid; = FONT-WEIGHT: normal; FONT-SIZE: 8pt; BORDER-LEFT: #404040 1px solid; = COLOR: #000000; BORDER-BOTTOM: #404040 1px solid; FONT-FAMILY: Arial, = Helvetica, sans-serif; BACKGROUND-COLOR: #ffffff; TEXT-DECORATION: none } TD.ContainerBodySubText { FONT-WEIGHT: normal; FONT-SIZE: 7pt; COLOR: #000000; FONT-FAMILY: = Arial, Helvetica, sans-serif; TEXT-DECORATION: none } TD.DialogHead { FONT-WEIGHT: bold; FONT-SIZE: 9pt; COLOR: #000000; FONT-FAMILY: Arial, = Helvetica, sans-serif; BACKGROUND-COLOR: #ffffff; TEXT-DECORATION: none } TD.DialogBody { FONT-WEIGHT: normal; FONT-SIZE: 9pt; COLOR: #000000; FONT-FAMILY: = Arial, Helvetica, sans-serif; BACKGROUND-COLOR: #ffffff; = TEXT-DECORATION: none } TD.MessageFeedback { COLOR: #00ff00; FONT-STYLE: italic } TD.ErrorFeedback { COLOR: #ff0000; FONT-STYLE: italic } TD.Footer { FONT: 8pt Arial } TD.TopBar { FONT-WEIGHT: bold; FONT-SIZE: 9pt; COLOR: #c0c0c0; FONT-FAMILY: Arial, = Helvetica, sans-serif } B { FONT: bold 9pt Arial; COLOR: #000000; TEXT-DECORATION: none } B.ContainerBodySubText { FONT-WEIGHT: bold; FONT-SIZE: 7pt; COLOR: #000000; FONT-FAMILY: Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } B.Italic { =09 } B.PageHead { FONT: 14pt Arial; COLOR: #999999 } B.SectionHead { FONT-WEIGHT: bold; COLOR: #333333 } B.Menu { FONT-WEIGHT: bold; COLOR: #000000 } B.MenuDisabled { FONT-WEIGHT: bold; COLOR: #c0c0c0 } B.Footer { FONT: bold 8pt Arial } .horzline { BACKGROUND-IMAGE: url(/images/dots_horz.gif); BACKGROUND-COLOR: #999999 } .breadcrumbBg { BACKGROUND-COLOR: #f7f7f7 } .whitelink { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #336699; FONT-FAMILY: = arial, helvetica, sans-serif; TEXT-DECORATION: none } .whitelink:hover { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #336699; FONT-FAMILY: = arial, helvetica, sans-serif; TEXT-DECORATION: underline } .leftnavlink { FONT-WEIGHT: normal; FONT-SIZE: 11px; WIDTH: 150px; COLOR: #333333; = TEXT-INDENT: 2px; FONT-FAMILY: arial,helvetica,sans-serif; = TEXT-DECORATION: none } .leftnavlink:hover { FONT-WEIGHT: normal; FONT-SIZE: 11px; COLOR: #333333; TEXT-INDENT: 2px; = FONT-FAMILY: arial,helvetica,sans-serif; TEXT-DECORATION: underline } .leftnavlinkdisabled { FONT-WEIGHT: normal; FONT-SIZE: 11px; COLOR: gray; TEXT-INDENT: 3px; = FONT-FAMILY: arial,helvetica,sans-serif } ------=_NextPart_000_0007_01C7189B.A539BAD0--