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Treatment
> Surgery of Low Grade
Gliomas / Temozolomide
Clinical Trials
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Journal of Neuro-Oncology, Volume 80, Number 2 / November, 2006, Pages 171-176,
DOI: 10.1007/s11060-006-9168-3. Published online: 28 April 2006
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Abstract |
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Radical surgery after chemotherapy: a
new therapeutic strategy to envision in grade II glioma Hugues Duffau1,* ,
Luc Taillandier2 and Laurent Capelle1
1Department
of Neurosurgery, UMR-S678, Inserm/UPMC, Hôpital Salpêtrière, 47-83
Bd de l’hôpital, 75651 Paris, Cedex 13, France. 2Department
of Neurology, CHU, Nancy, France. -- *Corrispondence: Hugues Duffau,
Email: hugues.duffau@psl.ap-hop-paris.fr -- Received: 5 March 2006 Accepted:
29 March 2006 Published online: 28 April 2006
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While surgery is proned in low-grade
glioma (LGG), the invasion of functional areas frequently prevents a
complete resection.
We report the first case of a patient
operated on for a left frontal LGG, diagnosed because of seizures,
with partial resection due to an invasion of the controlateral
hemisphere.
Chemotherapy enabled a regression of this
controlateral extension.
Postchemotherapy surgery performed with
intraoperative functional mapping then allowed a complete resection,
without sequelae.
The patient has a normal
socio-professional life, with no seizure.
No other treatment was given.
There was no recurrence, with a follow-up
of 2 years since the second surgery (3.5 years since the
first symptom).
We propose a new therapeutic strategy in
unresectable LGG, with preoperative chemotherapy, to make a radical
surgery possible in a second step, while preserving the quality of
life.
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© 2006 Springer
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Abstract |
Reprint
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