SpringerLink - Journal Article

Clinical=E2=80=93Patient = Studies

Radical = surgery after=20 chemotherapy: a new therapeutic strategy to envision = in grade=20 II glioma

Hugues Duffau¹, = Luc Taillandier² and=20 Laurent Capelle¹

(1)

Department of = Neurosurgery,=20 UMR-S678, Inserm/UPMC, H=C3=B4pital = Salp=C3=AAtri=C3=A8re, 47-83 Bd de=20 l=E2=80=99h=C3=B4pital, 75651 Paris, Cedex = 13,=20 France

(2)

Department of = Neurology,=20 CHU, Nancy, = France

Received:=20 = 5 March 2006 Accepted:=20 = 29 March 2006 Published=20 online: 28 April 2006

Abstract While surgery=20 is proned in low-grade glioma (LGG), the invasion of=20 functional areas frequently prevents a complete = resection. We=20 report the first case of a patient operated on for a = left=20 frontal LGG, diagnosed because of seizures, with = partial=20 resection due to an invasion of the controlateral = hemisphere.=20 Chemotherapy enabled a regression of this = controlateral=20 extension. Postchemotherapy surgery performed with=20 intraoperative functional mapping then allowed a = complete=20 resection, without sequelae. The patient has a normal=20 socio-professional life, with no seizure. No other = treatment=20 was given. There was no recurrence, with a follow-up = of=20 2 years since the second surgery (3.5 years = since=20 the first symptom). We propose a new therapeutic = strategy in=20 unresectable LGG, with preoperative chemotherapy, to = make a=20 radical surgery possible in a second step, while = preserving=20 the quality of life.

Keywords Low-grade=20 = glioma - Chemotherapy - Surgery - Brain=20 mapping

Hugues Duffau=
Email:=20 hugues.duffau@psl.ap-ho= p-paris.fr

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Clinical=E2=80=93Patient = Studies

References

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