From: Subject: Oncomirs [mdash] microRNAs with a role in cancer : Abstract : Nature Reviews Cancer Date: Fri, 9 May 2008 12:32:27 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0033_01C8B1D0.BE09B400" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_0033_01C8B1D0.BE09B400 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nrc/journal/v6/n4/abs/nrc1840.html Oncomirs [mdash] = microRNAs with a role in cancer : Abstract : Nature Reviews = Cancer

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Nature Reviews Cancer = 6, 259-269 = (April 2006) | = doi:10.1038/nrc1840

Oncomirs =97 microRNAs with a role in cancer

Aurora Esquela-Kerscher1=20 & Frank J. Slack1 =20 Abo= ut the=20 authors

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Abstract

MicroRNAs (miRNAs) are an abundant class of small=20 non-protein-coding RNAs that function as negative gene regulators. They = regulate=20 diverse biological processes, and bioinformatic data indicates that each = miRNA=20 can control hundreds of gene targets, underscoring the potential = influence of=20 miRNAs on almost every genetic pathway. Recent evidence has shown that = miRNA=20 mutations or mis-expression correlate with various human cancers and = indicates=20 that miRNAs can function as tumour suppressors and oncogenes. miRNAs = have been=20 shown to repress the expression of important cancer-related genes and = might=20 prove useful in the diagnosis and treatment of cancer.

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Author affiliations

  1. Yale University, Department of Molecular, Cellular &=20 Developmental Biology, 266 Whitney Avenue, New Haven, Connecticut = 06520,=20 USA.

Correspondence to: Frank J. Slack1=20 Email: frank.slack@yale.edu=20

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Not miR-ly = a=20 splicing factor: hnRNP A1 succumbs to microRNA temptation

Nature Structural & Molecular Biology News = and Views=20 (01 Jul 2007)

Drosha = versus ADAR:=20 wrangling over pri-miRNA

Nature Structural & Molecular Biology News = and Views=20 (01 Jan 2006)

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RESEARCH

MicroRN= A genes=20 are transcribed by RNA polymerase II

The EMBO Journal Article (13 Oct = 2004)

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Nature Reviews Cancer

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solid } #global-subject-areas H3.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #global-subject-areas UL UL { FONT-SIZE: 100% } #global-subject-areas UL LI { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = LINE-HEIGHT: 150%; PADDING-TOP: 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL LI LI { PADDING-RIGHT: 0px; PADDING-LEFT: 5px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #global-subject-areas UL LI H4 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H5 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: 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PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0.75em; = PADDING-TOP: 0px } DIV.natprodmore A:link { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_red.gif) no-repeat 0px 0.5em; COLOR: #c03; = TEXT-DECORATION: none } DIV.natprodmore A:visited { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_red.gif) no-repeat 0px 0.5em; COLOR: #c03; = TEXT-DECORATION: none } DIV.natprodmore A:focus { TEXT-DECORATION: underline } DIV.natprodmore A:hover { TEXT-DECORATION: underline } DIV.natprod SPAN { DISPLAY: block; FONT-SIZE: 70%; MARGIN-BOTTOM: 10px; LINE-HEIGHT: 110% } #natprod FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.natprodmore FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.natprodmore INPUT { MARGIN-TOP: 5px; FONT-SIZE: 110%; WIDTH: 98%! important } * HTML DIV.natprodmore INPUT { 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url(/reviews/images/icons/signup.gif) no-repeat 0px 3px } DIV.reg-rec UL A.recommend { BACKGROUND: url(/reviews/images/icons/tick.gif) no-repeat 0px 1px } DIV.reg-rec UL A.newsfeeds { BACKGROUND: url(/reviews/images/icons/newsfeeds.gif) no-repeat 0px 0px } DIV.reg-rec UL A.rtopten { BACKGROUND: url(/reviews/images/icons/topten.gif) no-repeat 0px 0px; = HEIGHT: 18px } DIV.reg-rec UL A.purchase { BACKGROUND: url(/reviews/images/icons/purchase.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 2px; PADDING-TOP: 2px } DIV.reg-rec UL A.bookmark { BACKGROUND: url(/reviews/images/icons/bookmark.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 1px; PADDING-TOP: 1px } * HTML DIV.reg-rec UL A.japanese { BACKGROUND: url(/reviews/images/icons/japanese.gif) no-repeat 0px 3px } DIV.reg-rec UL A.japanese { BACKGROUND: url(/reviews/images/icons/japanese.gif) no-repeat 0px 1px; = PADDING-BOTTOM: 1px; PADDING-TOP: 1px } .box#natjob { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; PADDING-BOTTOM: 6px; MARGIN: 0px = 0px 10px; COLOR: #000; PADDING-TOP: 6px } .box#natjob H2.natjob { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 7px; PADDING-LEFT: 7px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 120%; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px; FONT-FAMILY: = inherit; BORDER-RIGHT-WIDTH: 0px } .box#natjob H2.natjob SPAN.first { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natjob H2.natjob SPAN.second { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natjob H2.natjob SPAN.third { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natjob H2.natjob SPAN.first { COLOR: #f00 } .box#natjob H2.natjob SPAN.second { COLOR: #000 } .box#natjob UL.natjob { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 10px; MARGIN: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } .box#natjob UL.natjob LI H3 { FONT-SIZE: 110% } .box#natjob UL.natjob LI UL { FONT-SIZE: 110% } .box#natjob UL.natjob LI H3 A:link { TEXT-DECORATION: none } .box#natjob UL.natjob LI H3 A:visited { TEXT-DECORATION: none } .box#natjob UL.natjob LI H3 A:hover { TEXT-DECORATION: underline } .box#natjob UL.natjob LI H3 A:focus { TEXT-DECORATION: underline } .box#natjob DIV.natjobmore { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 110%; BACKGROUND-IMAGE: none; = BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-TOP: = 5px; LIST-STYLE-TYPE: none; BACKGROUND-COLOR: transparent; = BORDER-RIGHT-WIDTH: 0px } .box#natjob DIV.natjobmore A:link { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: = 100%; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; = TEXT-DECORATION: none } .box#natjob DIV.natjobmore A:visited { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: = 100%; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; = TEXT-DECORATION: none } .box#natjob DIV.natjobmore A:hover { TEXT-DECORATION: underline } .box#natjob DIV.natjobmore A:focus { TEXT-DECORATION: underline } .box#natprod { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; PADDING-BOTTOM: 6px; MARGIN: 0px = 0px 10px; COLOR: #000; PADDING-TOP: 6px } .box#natprod H2.natprod { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 7px; PADDING-LEFT: 7px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 120%; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px; FONT-FAMILY: = inherit; BORDER-RIGHT-WIDTH: 0px } .box#natprod H2.natprod SPAN.first { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natprod H2.natprod SPAN.second { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natprod H2.natprod SPAN.third { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natprod H2.natprod SPAN.first { COLOR: #f00 } .box#natprod H2.natprod SPAN.second { COLOR: #000 } .box#natprod FORM { MARGIN: 0px } .box#natprod DIV.natprodmore { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 1em; MARGIN: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } .box#natprod DIV.natprodmore INPUT { FONT-SIZE: 110% } DIV.ad-rh { FONT-SIZE: 110%; MARGIN: 0px 0px 20px; COLOR: #d6d6d6; TEXT-ALIGN: = center } DIV.ad-rh P { MARGIN: 0px } DIV.wide.skyscraper.ad-rh { TEXT-TRANSFORM: uppercase } DIV.masthead.ad-rh { BACKGROUND: url(/naturedotcom/images/graphics/bg.ad.masthead.gif) = #f3f3f3 no-repeat 50% 0px } DIV.ad-rh IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: bottom; BORDER-RIGHT-WIDTH: 0px } DIV.ad-rh EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: bottom; BORDER-RIGHT-WIDTH: 0px } DIV.wide.skyscraper.ad-rh IMG { MAX-WIDTH: 160px! important; MARGIN: 4px 0px 0px; WIDTH: 100% } DIV.wide.skyscraper.ad-rh EMBED { MAX-WIDTH: 160px! important; MARGIN: 4px 0px 0px; WIDTH: 100% } * HTML DIV.wide.skyscraper.ad-rh { MAX-WIDTH: 160px! important; MARGIN-LEFT: auto; OVERFLOW: hidden; = WIDTH: 100%; MARGIN-RIGHT: auto } .page-heading { PADDING-RIGHT: 10px; PADDING-LEFT: 7px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } .page-heading H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 150%! important; = PADDING-BOTTOM: 5px; MARGIN: 0px 3px 1em; PADDING-TOP: 5px } .page-heading H1.series { PADDING-LEFT: 39px; MIN-HEIGHT: 13px } H1.piccie { BACKGROUND: url(/reviews/images/rev.jpg) repeat-x left bottom; = PADDING-BOTTOM: 75px } .page-heading H1.page-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #content DIV.box { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; MARGIN: = 1em 0px; PADDING-TOP: 0px } #content DIV.box H2 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-SIZE: 110%; PADDING-BOTTOM: = 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px } #content DIV.box H3 { FONT-SIZE: 110%; MARGIN: 0px 0px 0.5em } #content DIV.box H4 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content DIV.box H5 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content DIV.box H6 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content DIV.box UL LI H2 { FONT-SIZE: 100% } #content DIV.box UL LI H3 { FONT-SIZE: 100% } #content DIV.box UL LI H4 { FONT-SIZE: 100% } #content DIV.box UL LI H5 { FONT-SIZE: 100% } #content DIV.box UL LI H6 { FONT-SIZE: 100% } #content DIV.box H3.emphasize { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 5px; MARGIN: 0px = 0px 1em; PADDING-TOP: 5px } #content DIV.box H3 .label { DISPLAY: block } #content DIV.box P { FONT-SIZE: 110%; MARGIN: 0px 0px 1em; LINE-HEIGHT: 190% } #content DIV.box UL LI P { FONT-SIZE: 100% } #content DIV.box A.pdf:link { PADDING-RIGHT: 3px; MARGIN-TOP: 3px; DISPLAY: block; PADDING-LEFT: = 30px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 3px; PADDING-TOP: 3px; = TEXT-DECORATION: none } #content DIV.box A.pdf:visited { PADDING-RIGHT: 3px; MARGIN-TOP: 3px; DISPLAY: block; PADDING-LEFT: = 30px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 3px; PADDING-TOP: 3px; = TEXT-DECORATION: none } #content DIV.box A.rss:link { PADDING-RIGHT: 3px; MARGIN-TOP: 3px; DISPLAY: block; PADDING-LEFT: = 30px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 3px; PADDING-TOP: 3px; = TEXT-DECORATION: none } #content DIV.box A.visited.rss { PADDING-RIGHT: 3px; MARGIN-TOP: 3px; DISPLAY: block; PADDING-LEFT: = 30px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 3px; PADDING-TOP: 3px; = TEXT-DECORATION: none } #content DIV.box A.pdf:link { BACKGROUND: url(/reviews/images/icons/pdf.gif) #f5f5f5 no-repeat 10px = 50% } #content DIV.box A.pdf:visited { BACKGROUND: url(/reviews/images/icons/pdf.gif) #f5f5f5 no-repeat 10px = 50% } #content DIV.box A.rss:link { PADDING-LEFT: 45px; BACKGROUND: 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