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Treatment
> Anticonvulsant
Pathology
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Neurology, Volume 67, Number 11, December 12, 2006
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Abstract |
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Psychotropic effects of antiepileptic
drugs
Alan B. Ettinger, MD
From North Shore-LIJ Comprehensive
Epilepsy Centers, New Hyde Park, NY. -- Address correspondence and
reprint requests to Dr. Alan B. Ettinger, EEG Lab, North Shore-LIJ,
Comprehensive Epilepsy Centers, 270-05 76th Ave., New Hyde Park, NY
11040; e-mail: aettinge@lij.edu --
Received March 30, 2006. Accepted in final form August 1, 2006.
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Background. Mood
disorder symptoms are common in patients with epilepsy.
Since antiepileptic drugs (AEDs) can
affect these symptoms, knowledge of the psychotropic
properties of AEDs is crucial.
We review most studies of the psychotropic
effects of AEDs that have involved potential psychiatric
applications and have been reported in the psychiatric
literature.
Methods. We conducted a
comprehensive literature search to identify relevant
clinical trial reports on the efficacy of AEDs for mood
disorders.
Results. There have been
few randomized controlled trials studying AED psychotropic
properties in patients with epilepsy, but some randomized
controlled trials of potential psychiatric indications for
AEDs have been published.
Data from these studies suggest that
specific AEDs have mood stabilizing, anxiolytic, and antidepressant
properties, while others may elicit depression, agitation, or
psychosis.
Conclusion. Antiepileptic
drug selection should consider potential effects on mood
and behavior.
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© 2006 American Academy of Neurology
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Abstract
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Data SD1,SD2,SD3
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