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Etiology and Pathogenesis
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Cancer
Stem Cells
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Cell
Proliferation, Volume 39, Issue 1, Page
3 - February 2006. (Mathematical
Model)
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Abstract |
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Mathematical model for the cancer stem
cell hypothesis
R. Ganguly and I. K. Puri
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Recent research on the origin of brain
cancer has implicated a subpopulation of self-renewing brain cancer
stem cells for malignant tumour growth.
Various genes that regulate self-renewal in normal stem cells are also
found in cancer stem cells.
This implies that cancers can occur because of mutations in normal
stem cells and early progenitor cells.
A predictive mathematical model based on the cell compartment method
is presented here to pose and validate non-intuitive scenarios
proposed through the neural cancer stem cell hypothesis.
The growths of abnormal (stem and early progenitor) cells from their
normal counterparts are ascribed with separate mutation
probabilities.
Stem cell mutations are found to be more significant for the
development of cancer than a similar mutation in the early progenitor
cells.
The model also predicts that, as previously hypothesized, repeated
insult to mature cells increases the formation of abnormal progeny,
and hence the risk of cancer.
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Affiliations: Department of Engineering
Science and Mechanics, Virginia Polytechnic Institute and State University,
Blacksburg, Virginia, USA
Correspondence: I. K. Puri, Department of Engineering Science and Mechanics,
Virginia Polytechnic Institute and State University, Blacksburg, Virginia
24061, USA. Tel.: (540)231 3243; Fax: (540)231 4574; E-mail: ikpuri@vt.edu.
Received 22 July 2005; revision accepted 7 November 2005.
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© 2006 Blackwell Publishing
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DOI: http://dx.doi.org/10.1111/j.1365-2184.2006.00369.x
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Source: http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2184.2006.00369.x
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