From: Subject: CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells - Nature Biotechnology Date: Wed, 17 May 2006 12:46:11 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C679AF.E0043E50" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C679AF.E0043E50 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nbt/journal/v24/n3/abs/nbt1197.html CD30 is a survival factor and a biomarker for = transformed human pluripotent stem cells - Nature Biotechnology
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Nature = Biotechnology=20 24, 351 - 357 (2006)
Published online: 26 = February=20 2006; | doi:10.1038/nbt1197

CD30 is a survival factor and a = biomarker for=20 transformed human pluripotent stem cells

Daniella=20 Herszfeld1, 5, Ernst=20 Wolvetang1, 5, Emma=20 Langton-Bunker1, Tung-Liang = Chung1, Adam=20 A Filipczyk1, Souheir Houssami1, = Pegah=20 Jamshidi1, Karen Koh1, Andrew L=20 Laslett1, Anna Michalska1, Linh=20 Nguyen1, Benjamin E=20 Reubinoff1, 4, Irene=20 Tellis1, Jonathan M Auerbach2, = Carol J=20 Ording2, Leendert H J Looijenga3 = & Martin F Pera1

1  Monash = Institute of=20 Medical Research, Monash University, and the = Australian Stem=20 Cell Centre, Bldg. 75 STRIP, Wellington Road, Clayton, = Victoria 3800 Australia.

2  Stem Cell = Center,=20 American Type Culture Collection, 10801 University = Boulevard,=20 Manassas, Virginia 20110, USA.

3  Pathology/Lab. = Exp.=20 Patho-Oncology, Erasmus MC=96University Medical Center = Rotterdam, Daniel den Hoed Cancer Center, Josephine = Nefkens=20 Institute, Building Be, Room 430b, P.O. Box 1738, 3000 = DR=20 Rotterdam, The Netherlands.

4  Present = address: The=20 Hadassah Human Embryonic Stem Cell Research Center, = The=20 Goldyne Savad Institute of Gene Therapy and The = Department of=20 Gynecology, Hadassah University Hospital, Ein-Kerem, = P.O.B.=20 12000, Jerusalem 91120, Israel.

5  These authors = contributed=20 equally to this work.

Correspondence=20 should be addressed to Martin F Pera martin.pera@med.monash.edu.= au

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M83554M83554M83554D86042D86042The = application of=20 human embryonic stem (hES) cells in regenerative = medicine will=20 require rigorous quality control measures to ensure = the safety=20 of hES cell=96derived grafts. During propagation in = vitro, hES cells can acquire cytogenetic=20 abnormalities1, 2,=20 3 as well as = submicroscopic=20 genetic lesions, such as small amplifications or=20 deletions4. Many of the genetic=20 abnormalities that arise in hES cell cultures are also = implicated in human cancer development. The causes of = genetic=20 instability of hES cells in culture are poorly = understood, and=20 commonly used cytogenetic methods for detection of = abnormal=20 cells are capable only of low-throughput analysis on = small=20 numbers of cells. The identification of biomarkers of = genetic=20 instability in hES cells would greatly facilitate the=20 development of culture methods that preserve genomic=20 integrity. Here we show that CD30, a member of the = tumor=20 necrosis factor receptor superfamily, is expressed on=20 transformed but not normal hES cells, and that CD30 = expression=20 protects hES cells against = apoptosis.
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FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.topnavsml:hover { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .leftnavOn { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnavOn { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnavOn:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnavOn:hover { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav:hover { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2 { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2:visited { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2:hover { FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2on { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2on:visited { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2on:hover { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3 { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3On { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3On:visited { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3On:hover { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subject { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subject:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subject:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subjectred { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subjectred:visited { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subjectred:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.closewindow { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow:hover { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow:visited { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow2 { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow2:hover { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow2:visited { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .search { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } A.adsearch { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.adsearch:visited { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.adsearch:hover { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .breadcrumb { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.breadcrumblink { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.breadcrumblink:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.breadcrumblink:hover { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .whitesml2 { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.whitesml2 { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.whitesml2:visited { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.whitesml2:hover { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .login { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.redsml { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.redsml:visited { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.redsml:hover { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.retraction { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.retraction:visited { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.retraction:hover { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.blacksml2 { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.blacksml2:hover { FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.blacksml2:visited { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.top { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.top:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.top:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .date { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .subjecttitle { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .subjecttext { FONT-SIZE: 10px; COLOR: #990000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.linksml { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.linksml:visited { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.linksml:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor2 { FONT-SIZE: x-small; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor2:visited { FONT-SIZE: x-small; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor2:hover { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.archivemonth { FONT-SIZE: xx-small; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.archivemonth:visited { FONT-SIZE: xx-small; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.archivemonth:hover { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.articletitle { FONT-WEIGHT: bold; FONT-SIZE: x-small; COLOR: #79791d; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articletitle:visited { FONT-WEIGHT: bold; FONT-SIZE: x-small; COLOR: #79791d; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articletitle:hover { FONT-WEIGHT: bold; FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .authorname { FONT-SIZE: 10px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .author { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .seealso { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .freeaccess { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .greysml { FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: #cccccc; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } .redsml2 { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .tochead { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #cc3300; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .tocsub { FONT-WEIGHT: bold; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #cc3300; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .blacksml { FONT-SIZE: xx-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .whitesml { FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: #ffffff; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } .webfocustext { FONT-SIZE: 11px; COLOR: #79791d; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .pagenum { FONT-SIZE: x-small; COLOR: #999999; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .pagenum2 { FONT-SIZE: xx-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .blacksml2 { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .blacksmltext { FONT-SIZE: xx-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .blacknorm { FONT-SIZE: 11px; COLOR: #000000; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.bodylink { FONT-SIZE: 12px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink:visited { FONT-SIZE: 12px; COLOR: #990099; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink:hover { FONT-SIZE: 12px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink2 { FONT-SIZE: 11px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink2:visited { FONT-SIZE: 11px; COLOR: #990099; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink2:hover { FONT-SIZE: 11px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink { FONT-SIZE: xx-small; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink:visited { FONT-SIZE: xx-small; COLOR: #925ab1; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink:hover { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink2 { FONT-SIZE: xx-small; COLOR: #0000ff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink2:visited { FONT-SIZE: xx-small; COLOR: #925ab1; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink2:hover { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.articlelink { FONT-SIZE: 10px; COLOR: #0000ff; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articlelink:visited { FONT-SIZE: 10px; COLOR: #990099; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articlelink:hover { FONT-SIZE: 10px; COLOR: #0000ff; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.login { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.login:visited { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.login:hover { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor { FONT-SIZE: 10px; COLOR: #666666; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.anchor:visited { FONT-SIZE: 10px; COLOR: #666666; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.anchor:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .articlelink { FONT-SIZE: 10px; COLOR: #0000ff; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .bottomnav { FONT-SIZE: 11px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.bottomnav { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; LINE-HEIGHT: 14px; = FONT-STYLE: normal; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } A.bottomnav:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; LINE-HEIGHT: 14px; = FONT-STYLE: normal; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } A.bottomnav:hover { FONT-SIZE: 11px; COLOR: #cc3300; LINE-HEIGHT: 14px; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.copyright { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.copyright:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.copyright:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.privacy { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.privacy:visited { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.privacy:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A { COLOR: #79791d; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } A:hover { COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } A:visited { COLOR: #79791d; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } A.footer { FONT-SIZE: 11px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.footer:hover { FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.footer:visited { FONT-SIZE: 11px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.greysmllink { FONT-SIZE: 10px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.greysmllink:hover { FONT-SIZE: 10px; COLOR: #cc3300; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.greysmllink:visited { FONT-SIZE: 10px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.popnav { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.popnav:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.popnav:visited { FONT-SIZE: 10px; COLOR: #79791d; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.sml { FONT-SIZE: 10px; COLOR: #79791d; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.sml:hover { FONT-SIZE: 10px; COLOR: #cc3300; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.sml:visited { FONT-SIZE: 10px; COLOR: #79791d; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .sponsor { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #990066; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .introtext { FONT-SIZE: 12px; COLOR: #000000; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .browsetext { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .browsehighlight { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #006666; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } A.browselink { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: 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