Regulating angiogenesis at the level of = PtdIns-4,5-P2

From: Subject: Regulating angiogenesis at the level of PtdIns-4,5-P2 Date: Fri, 19 May 2006 13:26:45 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0070_01C67B47.DFACDC20" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0070_01C67B47.DFACDC20 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/emboj/journal/v25/n10/abs/7601100a.html Regulating angiogenesis at the level of = PtdIns-4,5-P2

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Subject Categories: Signal=20 Transduction

The EMBO Journal (2006) 25, = 2075=962082,=20 doi:10.1038/sj.emboj.7601100
Published online 20 April=20 2006

Regulating angiogenesis at the level of=20 PtdIns-4,5-P₂

Eunok Im and Andrius Kazlauskas =

Schepens Eye Research Institute, Harvard = Medical=20 School, Boston, MA, USA

To whom correspondence should = be=20 addressed
Andrius Kazlauskas, Schepens Eye = Research=20 Institute, Harvard Medical School, 20 Staniford Street, = Boston, MA=20 02114, USA. Tel.: +1 617 912 2517; Fax: +1 617 912 0111; = E-mail: ak@eri.harvard.edu=20

Received 21 November 2005; Accepted 27 March 2006; = Published=20 online 20 April 2006.

Abstract

Angiogenesis is a coordinated sequence of = cellular=20 responses that result in the outgrowth of new blood vessels. = The=20 angiogenic program is regulated by extracellular factors, = whose=20 input is integrated at least in part at the level of signal=20 transduction pathways driven by phosphoinositide 3 kinase = (PI3K) and=20 phospholipase C 3Dgamma=20

(PLC

). Using an in vitro = angiogenesis=20 model, we discovered that PI3K was essential for tube = formation,=20 whereas PLC 3Dgamma=20

promoted regression. The = underlying mechanism=20 by which PLC 3Dgamma=20

antagonized tube formation = appeared to be by=20 competing with PI3K for their common substrate,=20 phosphatidylinositol-4,5-bisphosphate. These studies are the = first=20 to identify signaling enzymes involved with vessel = regression, and=20 reveal that the angiogenic program can be coordinated by the = availability of a membrane lipid.

Keywords: angiogenesis, PI3K, = PLC, PtdIns-4,5-P₂, tube=20 regression




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Privacy=20 policy	Copyright =A9 2006 by the = European Molecular=20 Biology Organization

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