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Etiology and Pathogenesis
> Cancer
Stem Cells
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Neuron, Volume 51, Issue 2, 20 July
2006, Pages 187-199; doi:10.1016/j.neuron.2006.06.012 ; Available
online 19 July 2006
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Abstract |
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PDGFRα-Positive B Cells Are Neural
Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response
to Increased PDGF Signaling
Erica L. Jackson 1,
Jose Manuel Garcia-Verdugo3, Sara
Gil-Perotin3, Monica Roy1,
Alfredo Quinones-Hinojosa1, 4,
Scott VandenBerg2 and Arturo
Alvarez-Buylla1,*
1Department of Neurological Surgery and Program in
Developmental and Stem Cell Biology, University of California, San
Francisco, San Francisco, California 94143. 2Departments of
Neurological Surgery and Pathology, University of California, San
Francisco, San Francisco, California 94143. 3University of
Valencia, Burjasot-4610 Valencia, Spain
*Corresponding author. Email: abuylla@stemcell.ucsf.edu
Received 4 January 2006; revised 19 April 2006; accepted 9
June 2006. Published: July 19, 2006. Available online 19 July 2006.
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Neurons and oligodendrocytes are produced
in the adult brain subventricular zone (SVZ) from neural stem cells (B
cells), which express GFAP and have morphological properties of
astrocytes.
We report here on the identification B cells expressing the PDGFRα
in the adult SVZ.
Specifically labeled PDGFRα expressing B cells in vivo
generate neurons and oligodendrocytes.
Conditional ablation of PDGFRα in a subpopulation of
postnatal stem cells showed that this receptor is required for
oligodendrogenesis, but not neurogenesis.
Infusion of PDGF alone was sufficient to arrest neuroblast
production and induce SVZ B cell proliferation contributing to the
generation of large hyperplasias with some features of gliomas.
The work demonstrates that PDGFRα signaling occurs early in
the adult stem cell lineage and may help regulate the balance between
oligodendrocyte and neuron production.
Excessive PDGF activation in the SVZ in stem cells is sufficient
to induce hallmarks associated with early stages of tumor formation.
Author Keywords: STEMCELL;
DEVBIO; MOLNEURO
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Copyright © 2006 Elsevier B.V. All
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