From: Subject: ScienceDirect - Cell : Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow Date: Mon, 15 May 2006 17:30:36 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C67845.46F49B30" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C67845.46F49B30 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencedirect.com/science?_ob=ArticleURL&_aset=V-WA-A-W-A-MsSAYZW-UUA-U-AAVUECBWYE-AABYCBVUYE-ZADBZEZWE-A-U&_rdoc=1&_fmt=summary&_udi=B6WSN-4J4B00R-V&_coverDate=01%2F27%2F2006&_cdi=7051&_orig=search&_st=13&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d76eb907e57099dc9c31956cb7a26f97 =EF=BB=BF ScienceDirect - Cell : Signals from the Sympathetic = Nervous System Regulate Hematopoietic Stem Cell Egress from Bone = Marrow
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Volume=20 124, Issue 2 , 27 January 2006, Pages 407-421
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doi:10.1016/j.cell.2005.10.041  &nb= sp; 3D"How  =20

Article

Signals from the Sympathetic Nervous System Regulate Hematopoietic = Stem Cell=20 Egress from Bone Marrow

Yoshio Katayama1,=20 2,=20 5= ,=20 Michela Battista1,=20 5= ,=20 Wei-Ming Kao1,=20 5= ,=20 Andr=C3=A9s Hidalgo1,=20 Anna J. Peired1,=20 Steven A. Thomas4=20 and Paul S. Frenette1,=20 3,=20 ,

1Department of=20 Medicine, Immunobiology Center and Black Family Stem Cell Institute, = Mount Sinai=20 School of Medicine, New York, NY 10029, USA
2Department of Hematology, Oncology, and = Respiratory=20 Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama = 700-8558,=20 Japan
3Mount Sinai School of Medicine, = Department=20 of Medicine, One Gustave L. Levy Place, Box 1079, New York, NY 10029, = USA
4Department of Pharmacology, University of=20 Pennsylvania, Philadelphia, PA 19104, USA

Received 15 April = 2005; =20 revised 19 September 2005;  accepted 27 October 2005.  = Published:=20 January 26, 2006.  Available online 26 January 2006.

Summary

Hematopoietic stem and progenitor cells (HSPC), attracted by the = chemokine=20 CXCL12, reside in specific niches in the bone marrow (BM). HSPC = migration out of=20 the BM is a critical process that underlies modern clinical stem cell=20 transplantation. Here we demonstrate that enforced HSPC egress from BM = niches=20 depends critically on the nervous system. UDP-galactose ceramide=20 galactosyltransferase-deficient = (Cgt=E2=88=92/=E2=88=92) mice exhibit aberrant=20 nerve conduction and display virtually no HSPC egress from BM following=20 granulocyte colony-stimulating factor (G-CSF) or fucoidan = administration.=20 Adrenergic tone, osteoblast function, and bone CXCL12 are dysregulated = in=20 Cgt=E2=88=92/=E2=88=92 mice. Pharmacological or = genetic ablation of adrenergic=20 neurotransmission indicates that norepinephrine (NE) signaling controls=20 G-CSF-induced osteoblast suppression, bone CXCL12 downregulation, and = HSPC=20 mobilization. Further, administration of a =CE=B22 adrenergic = agonist=20 enhances mobilization in both control and NE-deficient mice. Thus, these = results=20 indicate that the sympathetic nervous system regulates the attraction of = stem=20 cells to their niche.
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3D"CorrespondingPh: 212-659-9693; Fax: 212-849-2574
5 These authors contributed equally to = this work.=20


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