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Targeting Multiple Signaling Pathways
by Green Tea Polyphenol (–)-Epigallocatechin-3-Gallate
Naghma Khan, Farrukh
Afaq, Mohammad Saleem, Nihal Ahmad
and Hasan Mukhtar
Department of Dermatology,
University of Wisconsin-Madison, Madison, Wisconsin. Requests for
reprints: Hasan Mukhtar, Department of Dermatology, University of
Wisconsin-Madison, 1300, University Avenue, Medical Sciences Center,
B-25, Madison, WI 53706. Phone: 608-263-3927; Fax: 608-263-5223;
E-mail: hmukhtar@wisc.edu. Received 10/ 7/05;
revised 12/ 6/05; accepted 12/21/05.
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Cell signaling pathways, responsible for
maintaining a balance between cell proliferation and death,
have emerged as rational targets for the management of
cancer.
Emerging data amassed from various laboratories around the
world suggests that green tea, particularly its major
polyphenolic constituent (–)-epigallocatechin-3-gallate (EGCG),
possesses remarkable cancer chemopreventive and therapeutic potential
against various cancer sites in animal tumor bioassay systems
and in some human epidemiologic studies.
EGCG has been shown to modulate multiple signal
transduction pathways in a fashion that controls the
unwanted proliferation of cells, thereby imparting strong
cancer chemopreventive as well as therapeutic effects.
This review discusses the modulations of important signaling
events by EGCG and their implications in cancer management.
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