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Etiology and Pathogenesis
> Tumor
Biology
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Infectious Agents and Cancer 2006, 1:8; doi:10.1186/1750-9378-1-8;
Published 25 December 2006
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Abstract |
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Evolutionarily
new sequences expressed in tumors
Andrei P
Kozlov, Yuri P Galachyants, Ilya V Duhovlinov, Nickolai
A Samusik, Anna V Baranova, Dmitry E Polev and Larisa
L Krukovskaja
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Background.
Earlier we suggested the concept of the positive evolutionary
role of tumors.
According to this concept, tumors provide
conditions for the expression of evolutionarily new and/or sleeping
genes in their cells.
Thus, tumors are considered as
evolutionary proving ground or reservoir of expression.
To support this concept we have previously
characterized in silico and experimentally a new class of human
tumor-related transcribed sequences.
Results.
In this article we describe results of further studies of
previously described tumor-related sequences.
The results of molecular phylogeny
studies, Southern hybridization experiments and computational
comparison with genomes of other species are presented.
Conclusions.
These results suggest that these previously described
tumor-related human transcripts are also relatively evolutionarily
new.
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© 2006 BioMed
Central Ltd
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Abstract
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