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From: Subject: Print Date: Thu, 8 Jun 2006 11:43:29 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0009_01C68AF0.C3267760" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0009_01C68AF0.C3267760 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.asco.org/portal/site/ASCO/template.RAW/menuitem.34d60f5624ba07fd506fe310ee37a01d/?javax.portlet.tpst=0e116779df458209ada2be0aee37a01d_ws_RW&javax.portlet.prp_0e116779df458209ada2be0aee37a01d_viewID=abst_detail_rawview&javax.portlet.begCacheTok=com.vignette.cachetoken&javax.portlet.endCacheTok=com.vignette.cachetoken&index=n&confID=40&abstractID=32436 =EF=BB=BF Print

Improvement in neurocognitive function (NCF) correlates = with=20 tumor regression after whole brain radiation therapy (WBRT) = for=20 brain metastases (BM).

Sub-category:	CN= S=20 Tumors
Category:	Central Nervous System Tumors
Meeting:	2006=20 ASCO Annual Meeting =




Abstract No:	1504
Citation:	Journal of Clinical Oncology, 2006 ASCO Annual = Meeting=20 Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), = 2006:=20 1504
Author(s):	J. Li, S. M. Bentzen, M. Renschler, M. P. = Mehta
Abstract:	Background: Few prospective trials have explored = the=20 neurocognitive impact of WBRT in BM patients (pts), = complicated by=20 competing effects between benefit from WBRT and = deterioration due to=20 disease progression. Methods: 208 pts from the WBRT = alone arm=20 (30 Gy) of a phase III trial (PCYC-9801) evaluating = motexafin=20 gadolinium in BM were analyzed. NCF was assessed by 8 tests = of=20 memory, executive function and fine motor coordination, and=20 correlated to BM volume change by MRI, using Spearman's rank = correlation. Pts with tumor shrinkage below and above the = median=20 (45%) were compared for survival and NCF deterioration using = Kaplan-Meier analysis. Results: 135 pts (65%) were = evaluable=20 for BM volume at baseline and 2 months (mo). Pts were = divided into=20 "good" and "poor" responders based on % volume reduction at = 2 mo=20 above or below the population median of 45%. The = uni-directional=20 hypothesis of improved survival in good responders was = significant=20 (P =3D 0.03, median survival (MS) 300=C2=B126 days (d) vs = 240=C2=B119 d). For=20 all 8 tests, the median time to NCF deterioration was longer = in good=20 responders than in poor responders. Largest gains were for = an=20 executive function test Trailmaking B (131 d gain, = P=3D0.02), fine=20 motor tests Pegboard non-dominant hand (110 d gain, = P=3D0.05) and=20 Pegboard dominant hand (93 d gain, P=3D0.02). In 15 mo = survivors,=20 statistically significant correlation between tumor = shrinkage and=20 NCF preservation was seen for 4/8 NCF tests (r =3D = 0.68-0.88),=20 especially for executive function and fine motor = coordination. At=20 early follow-up, the population mean NCF scores were = dominated by=20 pts with progressive disease, as reflected by a sharp drop = in the=20 mean NCF scores at 4 mo. 15-mo survivors had stable or = improving=20 scores, associated with greater reduction in BM volume in = the 15=20 versus 4 mo survivors. Conclusions: WBRT-induced = tumor=20 shrinkage correlates with better survival and NCF = preservation. NCF=20 is stable or improved in long-term BM survivors. The adverse = impact=20 of tumor growth on neurocognitive function appears greater = than that=20 of WBRT.

Associated Presentation(s):

1. Improvement in neurocognitive function (NCF) correlates = with=20 tumor regression after whole brain radiation therapy (WBRT) = for=20 brain metastases (BM).

Meeting: 2006=20 ASCO Annual Meeting
Presenter: Jing=20 Li, MD, PhD
Session: Central=20 Nervous System Tumors (Oral Presentation) =

Other Abstracts in this Sub-Category

1. Initial = report of Radiation Therapy Oncology Group (RTOG) 9802: = Prospective=20 studies in adult low-grade glioma (LGG).

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 1500 = First=20 Author: E.=20 G. Shaw
Category: Central Nervous System Tumors - CN= S=20 Tumors

2. Study=20 design considerations for phase II trials of anaplastic = gliomas and=20 its impact on phase III survival studies.

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 1501 = First=20 Author: V.=20 A. Levin
Category: Central Nervous System Tumors - = CN= S=20 Tumors

3. Signific= ance=20 of necrosis in grading of anaplastic oligodendroglial = tumors: A=20 clinicopathological and genetic study of 916 high-grade = gliomas.=20

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 1502 = First=20 Author: C.=20 R. Miller
Category: Central Nervous System Tumors - = CN= S=20 Tumors

Mo= re...=20

Abstracts by J. Li

1. A=20 phase II study of gemcitabine and liposomal doxorubicin = (Lipo-Dox)=20 as first line chemotherapy in the treatment of metastatic = breast=20 cancer.

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 10688 = First=20 Author: N.=20 Yao
Category: Breast Cancer - Me= tastatic=20 Breast Cancer

2. A=20 pilot study of weekly versus 3-week docetaxel in combination = with=20 capecitabine in patients with anthracycline-pretreated = metastatic=20 breast cancer.

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 10771 = First=20 Author: Z.=20 Jiang
Category: Breast Cancer - Me= tastatic=20 Breast Cancer

3. Accelera= ted=20 fractionated radiation by concomitant boost (AFX-CB) with = concurrent=20 cis-platinum (CDDP) for advanced nasopharyngeal carcinoma. =

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 5540 = First=20 Author: W.=20 Choi
Category: H= ead=20 and Neck Cancer

More...=20

Presentations by J. Li

1. Improvement in neurocognitive function (NCF) correlates = with=20 tumor regression after whole brain radiation therapy (WBRT) = for=20 brain metastases (BM).

Meeting: 2006=20 ASCO Annual Meeting
Presenter: Jing=20 Li, MD, PhD
Session: Central=20 Nervous System Tumors (Oral Presentation) =

2. Population pharmacokinetic (PK)-pharmacodynamic (PD) = model for=20 gefitinib in cancer patients

Meeting: 2005=20 ASCO Annual Meeting
Presenter: Jing=20 Li, PhD
Session: Developmental=20 Therapeutics: Molecular Therapeutics (General Poster = Session)

More...=20

Journal of Clinical Oncology Articles by J. = Li

1. Whole-brain=20 radiotherapy in the management of brain metastasis. =

J Clin Oncol, United States
Vol 24, No 8 = (3/10/2006): pp.=20 1295-304

More...=20

PubMed Articles by Jing Li

1. Alterations=20 of rat corticostriatal synaptic plasticity after chronic = ethanol=20 exposure and withdrawal.

Alcohol Clin Exp Res, United States
Vol 30, No 5=20 (4/26/2006): pp. 819-24
PMID: 16634850 [PubMed - in = process]=20

2. Creation=20 of Engineered Cardiac Tissue In Vitro From Mouse Embryonic = Stem=20 Cells.

Circulation,
Vol , No (5/3/2006): pp.
PMID: = 16651472=20 [PubMed - in process]

3. Allelic=20 variation on chromosome 5 controls beta cell mass expansion = during=20 hyperglycemia in leptin receptor deficient diabetes mice. =

Endocrinology,
Vol , No (2/18/2006): pp.
PMID: = 16484328=20 [PubMed - in process]

More...=20

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Improvement in neurocognitive function (NCF) correlates = with=20 tumor regression after whole brain radiation therapy (WBRT) = for=20 brain metastases (BM).

Sub-category:

CN= S=20 Tumors

Category:

Central Nervous System Tumors

Meeting:

2006=20 ASCO Annual Meeting =

Abstract No:

1504

Citation:

Journal of Clinical Oncology, 2006 ASCO Annual = Meeting=20 Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), = 2006:=20 1504

Author(s):

J. Li, S. M. Bentzen, M. Renschler, M. P. = Mehta

Abstract:

Associated Presentation(s):

1.

Improvement in neurocognitive function (NCF) correlates = with=20 tumor regression after whole brain radiation therapy (WBRT) = for=20 brain metastases (BM).

Meeting: 2006=20 ASCO Annual Meeting Presenter: Jing=20 Li, MD, PhD Session: Central=20 Nervous System Tumors (Oral Presentation) =

Other Abstracts in this Sub-Category

1.

Initial = report of Radiation Therapy Oncology Group (RTOG) 9802: = Prospective=20 studies in adult low-grade glioma (LGG).

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 1500 = First=20 Author: E.=20 G. Shaw Category: Central Nervous System Tumors - CN= S=20 Tumors

2.

Study=20 design considerations for phase II trials of anaplastic = gliomas and=20 its impact on phase III survival studies.

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 1501 = First=20 Author: V.=20 A. Levin Category: Central Nervous System Tumors - = CN= S=20 Tumors

3.

Signific= ance=20 of necrosis in grading of anaplastic oligodendroglial = tumors: A=20 clinicopathological and genetic study of 916 high-grade = gliomas.=20

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 1502 = First=20 Author: C.=20 R. Miller Category: Central Nervous System Tumors - = CN= S=20 Tumors

Mo= re...=20

Abstracts by J. Li

1.

A=20 phase II study of gemcitabine and liposomal doxorubicin = (Lipo-Dox)=20 as first line chemotherapy in the treatment of metastatic = breast=20 cancer.

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 10688 = First=20 Author: N.=20 Yao Category: Breast Cancer - Me= tastatic=20 Breast Cancer

2.

A=20 pilot study of weekly versus 3-week docetaxel in combination = with=20 capecitabine in patients with anthracycline-pretreated = metastatic=20 breast cancer.

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 10771 = First=20 Author: Z.=20 Jiang Category: Breast Cancer - Me= tastatic=20 Breast Cancer

3.

Accelera= ted=20 fractionated radiation by concomitant boost (AFX-CB) with = concurrent=20 cis-platinum (CDDP) for advanced nasopharyngeal carcinoma. =

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 5540 = First=20 Author: W.=20 Choi Category: H= ead=20 and Neck Cancer

More...=20

Presentations by J. Li

1.

Improvement in neurocognitive function (NCF) correlates = with=20 tumor regression after whole brain radiation therapy (WBRT) = for=20 brain metastases (BM).

Meeting: 2006=20 ASCO Annual Meeting Presenter: Jing=20 Li, MD, PhD Session: Central=20 Nervous System Tumors (Oral Presentation) =

2.

Population pharmacokinetic (PK)-pharmacodynamic (PD) = model for=20 gefitinib in cancer patients

Meeting: 2005=20 ASCO Annual Meeting Presenter: Jing=20 Li, PhD Session: Developmental=20 Therapeutics: Molecular Therapeutics (General Poster = Session)

More...=20

Journal of Clinical Oncology Articles by J. = Li

1.

Whole-brain=20 radiotherapy in the management of brain metastasis. =

J Clin Oncol, United States Vol 24, No 8 = (3/10/2006): pp.=20 1295-304

More...=20

PubMed Articles by Jing Li

1.

Alterations=20 of rat corticostriatal synaptic plasticity after chronic = ethanol=20 exposure and withdrawal.

Alcohol Clin Exp Res, United States Vol 30, No 5=20 (4/26/2006): pp. 819-24 PMID: 16634850 [PubMed - in = process]=20

2.

Creation=20 of Engineered Cardiac Tissue In Vitro From Mouse Embryonic = Stem=20 Cells.

Circulation, Vol , No (5/3/2006): pp. PMID: = 16651472=20 [PubMed - in process]

3.

Allelic=20 variation on chromosome 5 controls beta cell mass expansion = during=20 hyperglycemia in leptin receptor deficient diabetes mice. =

Endocrinology, Vol , No (2/18/2006): pp. PMID: = 16484328=20 [PubMed - in process]

More...=20

Meeting: 2006=20 ASCO Annual Meeting
Presenter: Jing=20 Li, MD, PhD
Session: Central=20 Nervous System Tumors (Oral Presentation) =

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 1500 = First=20 Author: E.=20 G. Shaw
Category: Central Nervous System Tumors - CN= S=20 Tumors

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 1501 = First=20 Author: V.=20 A. Levin
Category: Central Nervous System Tumors - = CN= S=20 Tumors

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 1502 = First=20 Author: C.=20 R. Miller
Category: Central Nervous System Tumors - = CN= S=20 Tumors

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 10688 = First=20 Author: N.=20 Yao
Category: Breast Cancer - Me= tastatic=20 Breast Cancer

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 10771 = First=20 Author: Z.=20 Jiang
Category: Breast Cancer - Me= tastatic=20 Breast Cancer

Meeting: 2006=20 ASCO Annual Meeting Abstract No: 5540 = First=20 Author: W.=20 Choi
Category: H= ead=20 and Neck Cancer

Meeting: 2006=20 ASCO Annual Meeting
Presenter: Jing=20 Li, MD, PhD
Session: Central=20 Nervous System Tumors (Oral Presentation) =

Meeting: 2005=20 ASCO Annual Meeting
Presenter: Jing=20 Li, PhD
Session: Developmental=20 Therapeutics: Molecular Therapeutics (General Poster = Session)

J Clin Oncol, United States
Vol 24, No 8 = (3/10/2006): pp.=20 1295-304

Alcohol Clin Exp Res, United States
Vol 30, No 5=20 (4/26/2006): pp. 819-24
PMID: 16634850 [PubMed - in = process]=20

Circulation,
Vol , No (5/3/2006): pp.
PMID: = 16651472=20 [PubMed - in process]

Endocrinology,
Vol , No (2/18/2006): pp.
PMID: = 16484328=20 [PubMed - in process]