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Cancer Research, 66, 2497-2499, March 1, 2006. (Review Article)


Abstract

Oxidative Damage and Aging: Spotlight on Mitochondria

Nancy J. Linford1, Samuel E. Schriner2 and Peter S. Rabinovitch1

1Department of Pathology, University of Washington, Seattle, Washington and 2Center for Molecular and Mitochondrial Medicine and Genetics, Departments of Biological Chemistry and Ecology and Evolutionary Biology, University of California, Irvine, Irvine California. Requests for reprints: Nancy J. Linford, Department of Pathology, University of Washington, Box 357705, 1959 NE Pacific Avenue, HSB K081, Seattle, WA 98195. Phone: 206-616-8201; Fax: 206-616-8271; E-mail: nantzee@u.washington.edu. Received 9/22/05; revised 12/ 5/05; accepted 12/22/05.


Whereas free radical damage has been proposed as a key component in the tissue degeneration associated with aging, there has been little evidence that free radical damage limits life span in mammals. 
The current research shows that overexpression of the antioxidant enzyme catalase in mitochondria can extend mouse life span. 
These results highlight the importance of mitochondrial damage in aging and suggest that when targeted appropriately, boosting antioxidant defenses can increase mammalian life span.

© 2006 American Association for Cancer Research
Source: http://intl-cancerres.aacrjournals.org/cgi/content/abstract/66/5/2497
HTML Full Text: http://intl-cancerres.aacrjournals.org/cgi/content/full/66/5/2497
PDF Full Text: http://intl-cancerres.aacrjournals.org/cgi/reprint/66/5/2497


 

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